Replication confers β cell immaturity

Adult beta cells, which are highly specialised insulin-secreting cells, rarely replicate. Puri et al. demonstrate that beta cell proliferative capacity is inversely correlated with their functionality and differentiation state, by inducing proliferation of adult cells with ectopic overexpression of...

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Autores principales: Sapna Puri, Nilotpal Roy, Holger A. Russ, Laura Leonhardt, Esra K. French, Ritu Roy, Henrik Bengtsson, Donald K. Scott, Andrew F. Stewart, Matthias Hebrok
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/87ec84a80d19444a9d09ade990a1127e
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spelling oai:doaj.org-article:87ec84a80d19444a9d09ade990a1127e2021-12-02T17:31:26ZReplication confers β cell immaturity10.1038/s41467-018-02939-02041-1723https://doaj.org/article/87ec84a80d19444a9d09ade990a1127e2018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-02939-0https://doaj.org/toc/2041-1723Adult beta cells, which are highly specialised insulin-secreting cells, rarely replicate. Puri et al. demonstrate that beta cell proliferative capacity is inversely correlated with their functionality and differentiation state, by inducing proliferation of adult cells with ectopic overexpression of the cell cycle regulator c-Myc.Sapna PuriNilotpal RoyHolger A. RussLaura LeonhardtEsra K. FrenchRitu RoyHenrik BengtssonDonald K. ScottAndrew F. StewartMatthias HebrokNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Sapna Puri
Nilotpal Roy
Holger A. Russ
Laura Leonhardt
Esra K. French
Ritu Roy
Henrik Bengtsson
Donald K. Scott
Andrew F. Stewart
Matthias Hebrok
Replication confers β cell immaturity
description Adult beta cells, which are highly specialised insulin-secreting cells, rarely replicate. Puri et al. demonstrate that beta cell proliferative capacity is inversely correlated with their functionality and differentiation state, by inducing proliferation of adult cells with ectopic overexpression of the cell cycle regulator c-Myc.
format article
author Sapna Puri
Nilotpal Roy
Holger A. Russ
Laura Leonhardt
Esra K. French
Ritu Roy
Henrik Bengtsson
Donald K. Scott
Andrew F. Stewart
Matthias Hebrok
author_facet Sapna Puri
Nilotpal Roy
Holger A. Russ
Laura Leonhardt
Esra K. French
Ritu Roy
Henrik Bengtsson
Donald K. Scott
Andrew F. Stewart
Matthias Hebrok
author_sort Sapna Puri
title Replication confers β cell immaturity
title_short Replication confers β cell immaturity
title_full Replication confers β cell immaturity
title_fullStr Replication confers β cell immaturity
title_full_unstemmed Replication confers β cell immaturity
title_sort replication confers β cell immaturity
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/87ec84a80d19444a9d09ade990a1127e
work_keys_str_mv AT sapnapuri replicationconfersbcellimmaturity
AT nilotpalroy replicationconfersbcellimmaturity
AT holgeraruss replicationconfersbcellimmaturity
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AT esrakfrench replicationconfersbcellimmaturity
AT rituroy replicationconfersbcellimmaturity
AT henrikbengtsson replicationconfersbcellimmaturity
AT donaldkscott replicationconfersbcellimmaturity
AT andrewfstewart replicationconfersbcellimmaturity
AT matthiashebrok replicationconfersbcellimmaturity
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