Replication confers β cell immaturity

Adult beta cells, which are highly specialised insulin-secreting cells, rarely replicate. Puri et al. demonstrate that beta cell proliferative capacity is inversely correlated with their functionality and differentiation state, by inducing proliferation of adult cells with ectopic overexpression of...

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Main Authors:	Sapna Puri, Nilotpal Roy, Holger A. Russ, Laura Leonhardt, Esra K. French, Ritu Roy, Henrik Bengtsson, Donald K. Scott, Andrew F. Stewart, Matthias Hebrok
Format:	article
Language:	EN
Published:	Nature Portfolio 2018
Subjects:	Science Q
Online Access:	https://doaj.org/article/87ec84a80d19444a9d09ade990a1127e
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id	oai:doaj.org-article:87ec84a80d19444a9d09ade990a1127e
record_format	dspace
spelling	oai:doaj.org-article:87ec84a80d19444a9d09ade990a1127e2021-12-02T17:31:26ZReplication confers β cell immaturity10.1038/s41467-018-02939-02041-1723https://doaj.org/article/87ec84a80d19444a9d09ade990a1127e2018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-02939-0https://doaj.org/toc/2041-1723Adult beta cells, which are highly specialised insulin-secreting cells, rarely replicate. Puri et al. demonstrate that beta cell proliferative capacity is inversely correlated with their functionality and differentiation state, by inducing proliferation of adult cells with ectopic overexpression of the cell cycle regulator c-Myc.Sapna PuriNilotpal RoyHolger A. RussLaura LeonhardtEsra K. FrenchRitu RoyHenrik BengtssonDonald K. ScottAndrew F. StewartMatthias HebrokNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sapna Puri Nilotpal Roy Holger A. Russ Laura Leonhardt Esra K. French Ritu Roy Henrik Bengtsson Donald K. Scott Andrew F. Stewart Matthias Hebrok Replication confers β cell immaturity
description	Adult beta cells, which are highly specialised insulin-secreting cells, rarely replicate. Puri et al. demonstrate that beta cell proliferative capacity is inversely correlated with their functionality and differentiation state, by inducing proliferation of adult cells with ectopic overexpression of the cell cycle regulator c-Myc.
format	article
author	Sapna Puri Nilotpal Roy Holger A. Russ Laura Leonhardt Esra K. French Ritu Roy Henrik Bengtsson Donald K. Scott Andrew F. Stewart Matthias Hebrok
author_facet	Sapna Puri Nilotpal Roy Holger A. Russ Laura Leonhardt Esra K. French Ritu Roy Henrik Bengtsson Donald K. Scott Andrew F. Stewart Matthias Hebrok
author_sort	Sapna Puri
title	Replication confers β cell immaturity
title_short	Replication confers β cell immaturity
title_full	Replication confers β cell immaturity
title_fullStr	Replication confers β cell immaturity
title_full_unstemmed	Replication confers β cell immaturity
title_sort	replication confers β cell immaturity
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/87ec84a80d19444a9d09ade990a1127e
work_keys_str_mv	AT sapnapuri replicationconfersbcellimmaturity AT nilotpalroy replicationconfersbcellimmaturity AT holgeraruss replicationconfersbcellimmaturity AT lauraleonhardt replicationconfersbcellimmaturity AT esrakfrench replicationconfersbcellimmaturity AT rituroy replicationconfersbcellimmaturity AT henrikbengtsson replicationconfersbcellimmaturity AT donaldkscott replicationconfersbcellimmaturity AT andrewfstewart replicationconfersbcellimmaturity AT matthiashebrok replicationconfersbcellimmaturity
_version_	1718380625613815808

Replication confers β cell immaturity

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