COMPLEMENTARY FINDINGS ON THE ANTIMALARIAL ACTIVITY AND TOXICITY OF METHYLENE BLUE.

Methilene blue was reported as the first synthetic antimalarial by Ehrlich in 1881. It is currently no longer used for that purpose but it should be reconsidered since new economic alternatives are urgently needed in the arsenal of antimalarial drugs. The antimalarial activity of methylene blue is i...

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Autores principales:	Giovanny GARAVITO, Stephane BERTANI, Eric DEHARO
Formato:	article
Lenguaje:	EN
Publicado:	Universidad de Antioquia 2009
Materias:	Antimalarials Plasmodium Malaria Methylene blue. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
Acceso en línea:	https://doaj.org/article/87ecdf18866047ffb7fddfb81e0c5d04
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spelling	oai:doaj.org-article:87ecdf18866047ffb7fddfb81e0c5d042021-11-19T04:18:45ZCOMPLEMENTARY FINDINGS ON THE ANTIMALARIAL ACTIVITY AND TOXICITY OF METHYLENE BLUE.0121-40042145-2660https://doaj.org/article/87ecdf18866047ffb7fddfb81e0c5d042009-02-01T00:00:00Zhttps://revistas.udea.edu.co/index.php/vitae/article/view/770https://doaj.org/toc/0121-4004https://doaj.org/toc/2145-2660Methilene blue was reported as the first synthetic antimalarial by Ehrlich in 1881. It is currently no longer used for that purpose but it should be reconsidered since new economic alternatives are urgently needed in the arsenal of antimalarial drugs. The antimalarial activity of methylene blue is investigated here in vivo against rodent malaria parasites. 15 mg/kg daily dose of methylene blue inhibits 50% of the erythrocytic parasite growth of Plasmodium berghei and P. yoelii nigeriensis, while on hepatic stages of P. yoelii yoelii is almost inactive. In cell culture experiments with the lymphoblast-like BJAB cells line, it is 20 times more cytotoxic than chloroquine. Nevertheless, methylene blue shows a similar selectivity index as chloroquine against strains of different level of sensitivity of P. falciparum original from different geographical areas. Giovanny GARAVITOStephane BERTANIEric DEHAROUniversidad de AntioquiaarticleAntimalarialsPlasmodiumMalariaMethylene blue.Food processing and manufactureTP368-456Pharmaceutical industryHD9665-9675ENVitae, Vol 15, Iss 1 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Antimalarials Plasmodium Malaria Methylene blue. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
spellingShingle	Antimalarials Plasmodium Malaria Methylene blue. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675 Giovanny GARAVITO Stephane BERTANI Eric DEHARO COMPLEMENTARY FINDINGS ON THE ANTIMALARIAL ACTIVITY AND TOXICITY OF METHYLENE BLUE.
description	Methilene blue was reported as the first synthetic antimalarial by Ehrlich in 1881. It is currently no longer used for that purpose but it should be reconsidered since new economic alternatives are urgently needed in the arsenal of antimalarial drugs. The antimalarial activity of methylene blue is investigated here in vivo against rodent malaria parasites. 15 mg/kg daily dose of methylene blue inhibits 50% of the erythrocytic parasite growth of Plasmodium berghei and P. yoelii nigeriensis, while on hepatic stages of P. yoelii yoelii is almost inactive. In cell culture experiments with the lymphoblast-like BJAB cells line, it is 20 times more cytotoxic than chloroquine. Nevertheless, methylene blue shows a similar selectivity index as chloroquine against strains of different level of sensitivity of P. falciparum original from different geographical areas.
format	article
author	Giovanny GARAVITO Stephane BERTANI Eric DEHARO
author_facet	Giovanny GARAVITO Stephane BERTANI Eric DEHARO
author_sort	Giovanny GARAVITO
title	COMPLEMENTARY FINDINGS ON THE ANTIMALARIAL ACTIVITY AND TOXICITY OF METHYLENE BLUE.
title_short	COMPLEMENTARY FINDINGS ON THE ANTIMALARIAL ACTIVITY AND TOXICITY OF METHYLENE BLUE.
title_full	COMPLEMENTARY FINDINGS ON THE ANTIMALARIAL ACTIVITY AND TOXICITY OF METHYLENE BLUE.
title_fullStr	COMPLEMENTARY FINDINGS ON THE ANTIMALARIAL ACTIVITY AND TOXICITY OF METHYLENE BLUE.
title_full_unstemmed	COMPLEMENTARY FINDINGS ON THE ANTIMALARIAL ACTIVITY AND TOXICITY OF METHYLENE BLUE.
title_sort	complementary findings on the antimalarial activity and toxicity of methylene blue.
publisher	Universidad de Antioquia
publishDate	2009
url	https://doaj.org/article/87ecdf18866047ffb7fddfb81e0c5d04
work_keys_str_mv	AT giovannygaravito complementaryfindingsontheantimalarialactivityandtoxicityofmethyleneblue AT stephanebertani complementaryfindingsontheantimalarialactivityandtoxicityofmethyleneblue AT ericdeharo complementaryfindingsontheantimalarialactivityandtoxicityofmethyleneblue
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COMPLEMENTARY FINDINGS ON THE ANTIMALARIAL ACTIVITY AND TOXICITY OF METHYLENE BLUE.

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