Bcl11b is essential for licensing Th2 differentiation during helminth infection and allergic asthma

Th2 cells are critical in the resolution of helminth infection and allergy. Here the authors show that Bcl11b is required to license the Th2 program of helper T cell differentiation and restrict alternate lineage gene expression using in vivo models of helminth infection and asthma.

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Autores principales:	Kyle J. Lorentsen, Jonathan J. Cho, Xiaoping Luo, Ashley N. Zuniga, Joseph F. Urban, Liang Zhou, Raad Gharaibeh, Christian Jobin, Michael P. Kladde, Dorina Avram
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/87ef62254d384d3b86ba1e4fe2a30463
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spelling	oai:doaj.org-article:87ef62254d384d3b86ba1e4fe2a304632021-12-02T17:31:11ZBcl11b is essential for licensing Th2 differentiation during helminth infection and allergic asthma10.1038/s41467-018-04111-02041-1723https://doaj.org/article/87ef62254d384d3b86ba1e4fe2a304632018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04111-0https://doaj.org/toc/2041-1723Th2 cells are critical in the resolution of helminth infection and allergy. Here the authors show that Bcl11b is required to license the Th2 program of helper T cell differentiation and restrict alternate lineage gene expression using in vivo models of helminth infection and asthma.Kyle J. LorentsenJonathan J. ChoXiaoping LuoAshley N. ZunigaJoseph F. UrbanLiang ZhouRaad GharaibehChristian JobinMichael P. KladdeDorina AvramNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kyle J. Lorentsen Jonathan J. Cho Xiaoping Luo Ashley N. Zuniga Joseph F. Urban Liang Zhou Raad Gharaibeh Christian Jobin Michael P. Kladde Dorina Avram Bcl11b is essential for licensing Th2 differentiation during helminth infection and allergic asthma
description	Th2 cells are critical in the resolution of helminth infection and allergy. Here the authors show that Bcl11b is required to license the Th2 program of helper T cell differentiation and restrict alternate lineage gene expression using in vivo models of helminth infection and asthma.
format	article
author	Kyle J. Lorentsen Jonathan J. Cho Xiaoping Luo Ashley N. Zuniga Joseph F. Urban Liang Zhou Raad Gharaibeh Christian Jobin Michael P. Kladde Dorina Avram
author_facet	Kyle J. Lorentsen Jonathan J. Cho Xiaoping Luo Ashley N. Zuniga Joseph F. Urban Liang Zhou Raad Gharaibeh Christian Jobin Michael P. Kladde Dorina Avram
author_sort	Kyle J. Lorentsen
title	Bcl11b is essential for licensing Th2 differentiation during helminth infection and allergic asthma
title_short	Bcl11b is essential for licensing Th2 differentiation during helminth infection and allergic asthma
title_full	Bcl11b is essential for licensing Th2 differentiation during helminth infection and allergic asthma
title_fullStr	Bcl11b is essential for licensing Th2 differentiation during helminth infection and allergic asthma
title_full_unstemmed	Bcl11b is essential for licensing Th2 differentiation during helminth infection and allergic asthma
title_sort	bcl11b is essential for licensing th2 differentiation during helminth infection and allergic asthma
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/87ef62254d384d3b86ba1e4fe2a30463
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Bcl11b is essential for licensing Th2 differentiation during helminth infection and allergic asthma

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