Roles of metal ions in the selective inhibition of oncogenic variants of isocitrate dehydrogenase 1

Liu et al investigate the effects of divalent metal ions on catalysis and inhibition of the enzyme isocitrate dehydrogenase (IDH) and its cancer-linked variant R132H. They further identify the substrates for IDH as complexes with Mg2+ and show that allosteric inhibitors work by weakening Mg2+ bindin...

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Autores principales:	Shuang Liu, Martine I. Abboud, Tobias John, Victor Mikhailov, Ingvild Hvinden, John Walsby-Tickle, Xiao Liu, Ilaria Pettinati, Tom Cadoux-Hudson, James S. O. McCullagh, Christopher J. Schofield
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/87f044b46ee747dba26b0e27f7cc54e6
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spelling	oai:doaj.org-article:87f044b46ee747dba26b0e27f7cc54e62021-11-07T12:20:38ZRoles of metal ions in the selective inhibition of oncogenic variants of isocitrate dehydrogenase 110.1038/s42003-021-02743-52399-3642https://doaj.org/article/87f044b46ee747dba26b0e27f7cc54e62021-11-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02743-5https://doaj.org/toc/2399-3642Liu et al investigate the effects of divalent metal ions on catalysis and inhibition of the enzyme isocitrate dehydrogenase (IDH) and its cancer-linked variant R132H. They further identify the substrates for IDH as complexes with Mg2+ and show that allosteric inhibitors work by weakening Mg2+ binding of R132H, providing mechanistic insights into the basis for selective R132H IDH1 inhibition.Shuang LiuMartine I. AbboudTobias JohnVictor MikhailovIngvild HvindenJohn Walsby-TickleXiao LiuIlaria PettinatiTom Cadoux-HudsonJames S. O. McCullaghChristopher J. SchofieldNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Shuang Liu Martine I. Abboud Tobias John Victor Mikhailov Ingvild Hvinden John Walsby-Tickle Xiao Liu Ilaria Pettinati Tom Cadoux-Hudson James S. O. McCullagh Christopher J. Schofield Roles of metal ions in the selective inhibition of oncogenic variants of isocitrate dehydrogenase 1
description	Liu et al investigate the effects of divalent metal ions on catalysis and inhibition of the enzyme isocitrate dehydrogenase (IDH) and its cancer-linked variant R132H. They further identify the substrates for IDH as complexes with Mg2+ and show that allosteric inhibitors work by weakening Mg2+ binding of R132H, providing mechanistic insights into the basis for selective R132H IDH1 inhibition.
format	article
author	Shuang Liu Martine I. Abboud Tobias John Victor Mikhailov Ingvild Hvinden John Walsby-Tickle Xiao Liu Ilaria Pettinati Tom Cadoux-Hudson James S. O. McCullagh Christopher J. Schofield
author_facet	Shuang Liu Martine I. Abboud Tobias John Victor Mikhailov Ingvild Hvinden John Walsby-Tickle Xiao Liu Ilaria Pettinati Tom Cadoux-Hudson James S. O. McCullagh Christopher J. Schofield
author_sort	Shuang Liu
title	Roles of metal ions in the selective inhibition of oncogenic variants of isocitrate dehydrogenase 1
title_short	Roles of metal ions in the selective inhibition of oncogenic variants of isocitrate dehydrogenase 1
title_full	Roles of metal ions in the selective inhibition of oncogenic variants of isocitrate dehydrogenase 1
title_fullStr	Roles of metal ions in the selective inhibition of oncogenic variants of isocitrate dehydrogenase 1
title_full_unstemmed	Roles of metal ions in the selective inhibition of oncogenic variants of isocitrate dehydrogenase 1
title_sort	roles of metal ions in the selective inhibition of oncogenic variants of isocitrate dehydrogenase 1
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/87f044b46ee747dba26b0e27f7cc54e6
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Roles of metal ions in the selective inhibition of oncogenic variants of isocitrate dehydrogenase 1

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