Combined nicotinamide N-methyltransferase inhibition and reduced-calorie diet normalizes body composition and enhances metabolic benefits in obese mice

Combined nicotinamide N-methyltransferase inhibition and reduced-calorie diet normalizes body composition and enhances metabolic benefits in obese mice

Abstract Obesity is a large and growing global health problem with few effective therapies. The present study investigated metabolic and physiological benefits of nicotinamide N-methyltransferase inhibitor (NNMTi) treatment combined with a lean diet substitution in diet-induced obese mice. NNMTi tre...

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Autores principales: Catherine M. Sampson, Andrea L. Dimet, Harshini Neelakantan, Kehinde O. Ogunseye, Heather L. Stevenson, Jonathan D. Hommel, Stanley J. Watowich
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/87f2fa77c3f847f5b4521dfa072c052a
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