Identification of two different coagulation phenotypes in people living with HIV with undetectable viral replication

Abstract Altered coagulation has been reported in people living with HIV (PLWH) with ongoing viral replication and may predispose to cardiovascular diseases. However, less is known about coagulation in PLWH with undetectable viral replication. In a cross-sectional observational study, we investigate...

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Autores principales:	Asbjørn Fink, Andreas Dehlbæk Knudsen, Rebekka Faber Thudium, Jakob Hjorth Von Stemann, Shoaib Afzal, Jens Lundgren, Ditte Marie Kirkegaard-Klitbo, Sisse Rye Ostrowski, Børge G. Nordestgaard, Susanne Dam Nielsen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/87f37d3528f24bdd8187de4abb5cc14b
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spelling	oai:doaj.org-article:87f37d3528f24bdd8187de4abb5cc14b2021-12-02T14:28:18ZIdentification of two different coagulation phenotypes in people living with HIV with undetectable viral replication10.1038/s41598-021-83731-x2045-2322https://doaj.org/article/87f37d3528f24bdd8187de4abb5cc14b2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83731-xhttps://doaj.org/toc/2045-2322Abstract Altered coagulation has been reported in people living with HIV (PLWH) with ongoing viral replication and may predispose to cardiovascular diseases. However, less is known about coagulation in PLWH with undetectable viral replication. In a cross-sectional observational study, we investigated whether HIV infection with undetectable viral replication is independently associated with activated partial thromboplastin time (APTT) and coagulation factor II–VII–X concentrations out of reference. Logistic regression analyses were used to assess the association of HIV infection with APTT and coagulation factor II–VII–X, after adjusting for age, sex, smoking status, alcohol consumption, BMI, diabetes and hsCRP. 936 PLWH with undetectable viral replication from the Copenhagen Co-morbidity in HIV infection study (COCOMO-study) and 2955 uninfected controls were included. Higher prevalence of short APTT was found in PLWH compared to controls (13.5% vs. 7.6%, P < 0.001). Furthermore, higher prevalence of low coagulation factor II–VII–X was found in PLWH than in controls (9.6% vs. 7.4%, P = 0.022). HIV was independently associated with short APTT (adjusted odds ratio (aOR) 2.3 (95% CI 1.7–2.9), P < 0.001) and low coagulation factor II–VII–X (aOR 1.4 (95% CI 1.0–1.9), P = 0.046). Few participants among PLWH and controls had both short APTT and low coagulation factor II–VII–X, 2.1% vs. 0.8%, respectively. We found evidence of both procoagulant (short APTT) and anticoagulant (low coagulation factor II–VII–X) alterations in PLWH with undetectable viral replication, and our findings suggest that two different coagulation phenotypes exist in participants with treated HIV infection.Asbjørn FinkAndreas Dehlbæk KnudsenRebekka Faber ThudiumJakob Hjorth Von StemannShoaib AfzalJens LundgrenDitte Marie Kirkegaard-KlitboSisse Rye OstrowskiBørge G. NordestgaardSusanne Dam NielsenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Asbjørn Fink Andreas Dehlbæk Knudsen Rebekka Faber Thudium Jakob Hjorth Von Stemann Shoaib Afzal Jens Lundgren Ditte Marie Kirkegaard-Klitbo Sisse Rye Ostrowski Børge G. Nordestgaard Susanne Dam Nielsen Identification of two different coagulation phenotypes in people living with HIV with undetectable viral replication
description	Abstract Altered coagulation has been reported in people living with HIV (PLWH) with ongoing viral replication and may predispose to cardiovascular diseases. However, less is known about coagulation in PLWH with undetectable viral replication. In a cross-sectional observational study, we investigated whether HIV infection with undetectable viral replication is independently associated with activated partial thromboplastin time (APTT) and coagulation factor II–VII–X concentrations out of reference. Logistic regression analyses were used to assess the association of HIV infection with APTT and coagulation factor II–VII–X, after adjusting for age, sex, smoking status, alcohol consumption, BMI, diabetes and hsCRP. 936 PLWH with undetectable viral replication from the Copenhagen Co-morbidity in HIV infection study (COCOMO-study) and 2955 uninfected controls were included. Higher prevalence of short APTT was found in PLWH compared to controls (13.5% vs. 7.6%, P < 0.001). Furthermore, higher prevalence of low coagulation factor II–VII–X was found in PLWH than in controls (9.6% vs. 7.4%, P = 0.022). HIV was independently associated with short APTT (adjusted odds ratio (aOR) 2.3 (95% CI 1.7–2.9), P < 0.001) and low coagulation factor II–VII–X (aOR 1.4 (95% CI 1.0–1.9), P = 0.046). Few participants among PLWH and controls had both short APTT and low coagulation factor II–VII–X, 2.1% vs. 0.8%, respectively. We found evidence of both procoagulant (short APTT) and anticoagulant (low coagulation factor II–VII–X) alterations in PLWH with undetectable viral replication, and our findings suggest that two different coagulation phenotypes exist in participants with treated HIV infection.
format	article
author	Asbjørn Fink Andreas Dehlbæk Knudsen Rebekka Faber Thudium Jakob Hjorth Von Stemann Shoaib Afzal Jens Lundgren Ditte Marie Kirkegaard-Klitbo Sisse Rye Ostrowski Børge G. Nordestgaard Susanne Dam Nielsen
author_facet	Asbjørn Fink Andreas Dehlbæk Knudsen Rebekka Faber Thudium Jakob Hjorth Von Stemann Shoaib Afzal Jens Lundgren Ditte Marie Kirkegaard-Klitbo Sisse Rye Ostrowski Børge G. Nordestgaard Susanne Dam Nielsen
author_sort	Asbjørn Fink
title	Identification of two different coagulation phenotypes in people living with HIV with undetectable viral replication
title_short	Identification of two different coagulation phenotypes in people living with HIV with undetectable viral replication
title_full	Identification of two different coagulation phenotypes in people living with HIV with undetectable viral replication
title_fullStr	Identification of two different coagulation phenotypes in people living with HIV with undetectable viral replication
title_full_unstemmed	Identification of two different coagulation phenotypes in people living with HIV with undetectable viral replication
title_sort	identification of two different coagulation phenotypes in people living with hiv with undetectable viral replication
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/87f37d3528f24bdd8187de4abb5cc14b
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Identification of two different coagulation phenotypes in people living with HIV with undetectable viral replication

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