Molecular landscape and subtype-specific therapeutic response of nasopharyngeal carcinoma revealed by integrative pharmacogenomics

Nasopharyngeal carcinoma (NPC) is a malignant cancer type with high morbidity in Asia, and its current molecular classification is insufficient to predict therapy outcomes. Here the authors explore NPC subtype-specific response to therapy with a pharmacogenomics strategy integrating genomics and dru...

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Autores principales:	Ren-Bo Ding, Ping Chen, Barani Kumar Rajendran, Xueying Lyu, Haitao Wang, Jiaolin Bao, Jianming Zeng, Wenhui Hao, Heng Sun, Ada Hang-Heng Wong, Monica Vishnu Valecha, Eun Ju Yang, Sek Man Su, Tak Kan Choi, Shuiming Liu, Kin Iong Chan, Ling-Lin Yang, Jingbo Wu, Kai Miao, Qiang Chen, Joong Sup Shim, Xiaoling Xu, Chu-Xia Deng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/87f829886bef4facb841e43c9c543db3
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spelling	oai:doaj.org-article:87f829886bef4facb841e43c9c543db32021-12-02T14:42:18ZMolecular landscape and subtype-specific therapeutic response of nasopharyngeal carcinoma revealed by integrative pharmacogenomics10.1038/s41467-021-23379-32041-1723https://doaj.org/article/87f829886bef4facb841e43c9c543db32021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23379-3https://doaj.org/toc/2041-1723Nasopharyngeal carcinoma (NPC) is a malignant cancer type with high morbidity in Asia, and its current molecular classification is insufficient to predict therapy outcomes. Here the authors explore NPC subtype-specific response to therapy with a pharmacogenomics strategy integrating genomics and drug response of patient-derived organoids.Ren-Bo DingPing ChenBarani Kumar RajendranXueying LyuHaitao WangJiaolin BaoJianming ZengWenhui HaoHeng SunAda Hang-Heng WongMonica Vishnu ValechaEun Ju YangSek Man SuTak Kan ChoiShuiming LiuKin Iong ChanLing-Lin YangJingbo WuKai MiaoQiang ChenJoong Sup ShimXiaoling XuChu-Xia DengNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ren-Bo Ding Ping Chen Barani Kumar Rajendran Xueying Lyu Haitao Wang Jiaolin Bao Jianming Zeng Wenhui Hao Heng Sun Ada Hang-Heng Wong Monica Vishnu Valecha Eun Ju Yang Sek Man Su Tak Kan Choi Shuiming Liu Kin Iong Chan Ling-Lin Yang Jingbo Wu Kai Miao Qiang Chen Joong Sup Shim Xiaoling Xu Chu-Xia Deng Molecular landscape and subtype-specific therapeutic response of nasopharyngeal carcinoma revealed by integrative pharmacogenomics
description	Nasopharyngeal carcinoma (NPC) is a malignant cancer type with high morbidity in Asia, and its current molecular classification is insufficient to predict therapy outcomes. Here the authors explore NPC subtype-specific response to therapy with a pharmacogenomics strategy integrating genomics and drug response of patient-derived organoids.
format	article
author	Ren-Bo Ding Ping Chen Barani Kumar Rajendran Xueying Lyu Haitao Wang Jiaolin Bao Jianming Zeng Wenhui Hao Heng Sun Ada Hang-Heng Wong Monica Vishnu Valecha Eun Ju Yang Sek Man Su Tak Kan Choi Shuiming Liu Kin Iong Chan Ling-Lin Yang Jingbo Wu Kai Miao Qiang Chen Joong Sup Shim Xiaoling Xu Chu-Xia Deng
author_facet	Ren-Bo Ding Ping Chen Barani Kumar Rajendran Xueying Lyu Haitao Wang Jiaolin Bao Jianming Zeng Wenhui Hao Heng Sun Ada Hang-Heng Wong Monica Vishnu Valecha Eun Ju Yang Sek Man Su Tak Kan Choi Shuiming Liu Kin Iong Chan Ling-Lin Yang Jingbo Wu Kai Miao Qiang Chen Joong Sup Shim Xiaoling Xu Chu-Xia Deng
author_sort	Ren-Bo Ding
title	Molecular landscape and subtype-specific therapeutic response of nasopharyngeal carcinoma revealed by integrative pharmacogenomics
title_short	Molecular landscape and subtype-specific therapeutic response of nasopharyngeal carcinoma revealed by integrative pharmacogenomics
title_full	Molecular landscape and subtype-specific therapeutic response of nasopharyngeal carcinoma revealed by integrative pharmacogenomics
title_fullStr	Molecular landscape and subtype-specific therapeutic response of nasopharyngeal carcinoma revealed by integrative pharmacogenomics
title_full_unstemmed	Molecular landscape and subtype-specific therapeutic response of nasopharyngeal carcinoma revealed by integrative pharmacogenomics
title_sort	molecular landscape and subtype-specific therapeutic response of nasopharyngeal carcinoma revealed by integrative pharmacogenomics
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/87f829886bef4facb841e43c9c543db3
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Molecular landscape and subtype-specific therapeutic response of nasopharyngeal carcinoma revealed by integrative pharmacogenomics

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