Human snoRNA-93 is processed into a microRNA-like RNA that promotes breast cancer cell invasion

RNA: Small nucleolar-derived RNA contributes to tumor invasiveness A short microRNA-like fragment excised from a small nucleolar RNA (called a snoRNA-derived RNA or sdRNA) contributes to the invasiveness of breast cancer cells. Glen Borchert from the University of South Alabama, USA, and colleagues...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Dillon G. Patterson, Justin T. Roberts, Valeria M. King, Dominika Houserova, Emmaline C. Barnhill, Aline Crucello, Caroline J. Polska, Lucas W. Brantley, Garrett C. Kaufman, Michael Nguyen, Megann W. Santana, Ian A. Schiller, Julius S. Spicciani, Anastasia K. Zapata, Molly M. Miller, Timothy D. Sherman, Ruixia Ma, Hongyou Zhao, Ritu Arora, Alexander B. Coley, Melody M. Zeidan, Ming Tan, Yaguang Xi, Glen M. Borchert
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/87f99f130ab34eb6904092036250f50d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:87f99f130ab34eb6904092036250f50d
record_format	dspace
spelling	oai:doaj.org-article:87f99f130ab34eb6904092036250f50d2021-12-02T15:18:47ZHuman snoRNA-93 is processed into a microRNA-like RNA that promotes breast cancer cell invasion10.1038/s41523-017-0032-82374-4677https://doaj.org/article/87f99f130ab34eb6904092036250f50d2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41523-017-0032-8https://doaj.org/toc/2374-4677RNA: Small nucleolar-derived RNA contributes to tumor invasiveness A short microRNA-like fragment excised from a small nucleolar RNA (called a snoRNA-derived RNA or sdRNA) contributes to the invasiveness of breast cancer cells. Glen Borchert from the University of South Alabama, USA, and colleagues compared the expression of sdRNAs between a primary breast cancer cell line and a metastatic one. They identified 13 sdRNAs with markedly different abundances. Blocking the sdRNA with the biggest expression differential sdRNA-93-decreased cellular invasion, whereas increasing its abundance enhanced tumor cell invasiveness. Looking at human tissues, sdRNA-93 was routinely expressed in biopsies taken from patients with the luminal HER2-positive form of breast cancer, less often in other tumor types and almost never in healthy breast samples. Hinting at its function, the researchers showed that sdRNA-93 targets and regulates a gene contributing to specific molecular subtypes of breast cancer.Dillon G. PattersonJustin T. RobertsValeria M. KingDominika HouserovaEmmaline C. BarnhillAline CrucelloCaroline J. PolskaLucas W. BrantleyGarrett C. KaufmanMichael NguyenMegann W. SantanaIan A. SchillerJulius S. SpiccianiAnastasia K. ZapataMolly M. MillerTimothy D. ShermanRuixia MaHongyou ZhaoRitu AroraAlexander B. ColeyMelody M. ZeidanMing TanYaguang XiGlen M. BorchertNature PortfolioarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Breast Cancer, Vol 3, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Dillon G. Patterson Justin T. Roberts Valeria M. King Dominika Houserova Emmaline C. Barnhill Aline Crucello Caroline J. Polska Lucas W. Brantley Garrett C. Kaufman Michael Nguyen Megann W. Santana Ian A. Schiller Julius S. Spicciani Anastasia K. Zapata Molly M. Miller Timothy D. Sherman Ruixia Ma Hongyou Zhao Ritu Arora Alexander B. Coley Melody M. Zeidan Ming Tan Yaguang Xi Glen M. Borchert Human snoRNA-93 is processed into a microRNA-like RNA that promotes breast cancer cell invasion
description	RNA: Small nucleolar-derived RNA contributes to tumor invasiveness A short microRNA-like fragment excised from a small nucleolar RNA (called a snoRNA-derived RNA or sdRNA) contributes to the invasiveness of breast cancer cells. Glen Borchert from the University of South Alabama, USA, and colleagues compared the expression of sdRNAs between a primary breast cancer cell line and a metastatic one. They identified 13 sdRNAs with markedly different abundances. Blocking the sdRNA with the biggest expression differential sdRNA-93-decreased cellular invasion, whereas increasing its abundance enhanced tumor cell invasiveness. Looking at human tissues, sdRNA-93 was routinely expressed in biopsies taken from patients with the luminal HER2-positive form of breast cancer, less often in other tumor types and almost never in healthy breast samples. Hinting at its function, the researchers showed that sdRNA-93 targets and regulates a gene contributing to specific molecular subtypes of breast cancer.
format	article
author	Dillon G. Patterson Justin T. Roberts Valeria M. King Dominika Houserova Emmaline C. Barnhill Aline Crucello Caroline J. Polska Lucas W. Brantley Garrett C. Kaufman Michael Nguyen Megann W. Santana Ian A. Schiller Julius S. Spicciani Anastasia K. Zapata Molly M. Miller Timothy D. Sherman Ruixia Ma Hongyou Zhao Ritu Arora Alexander B. Coley Melody M. Zeidan Ming Tan Yaguang Xi Glen M. Borchert
author_facet	Dillon G. Patterson Justin T. Roberts Valeria M. King Dominika Houserova Emmaline C. Barnhill Aline Crucello Caroline J. Polska Lucas W. Brantley Garrett C. Kaufman Michael Nguyen Megann W. Santana Ian A. Schiller Julius S. Spicciani Anastasia K. Zapata Molly M. Miller Timothy D. Sherman Ruixia Ma Hongyou Zhao Ritu Arora Alexander B. Coley Melody M. Zeidan Ming Tan Yaguang Xi Glen M. Borchert
author_sort	Dillon G. Patterson
title	Human snoRNA-93 is processed into a microRNA-like RNA that promotes breast cancer cell invasion
title_short	Human snoRNA-93 is processed into a microRNA-like RNA that promotes breast cancer cell invasion
title_full	Human snoRNA-93 is processed into a microRNA-like RNA that promotes breast cancer cell invasion
title_fullStr	Human snoRNA-93 is processed into a microRNA-like RNA that promotes breast cancer cell invasion
title_full_unstemmed	Human snoRNA-93 is processed into a microRNA-like RNA that promotes breast cancer cell invasion
title_sort	human snorna-93 is processed into a microrna-like rna that promotes breast cancer cell invasion
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/87f99f130ab34eb6904092036250f50d
work_keys_str_mv	AT dillongpatterson humansnorna93isprocessedintoamicrornalikernathatpromotesbreastcancercellinvasion AT justintroberts humansnorna93isprocessedintoamicrornalikernathatpromotesbreastcancercellinvasion AT valeriamking humansnorna93isprocessedintoamicrornalikernathatpromotesbreastcancercellinvasion AT dominikahouserova humansnorna93isprocessedintoamicrornalikernathatpromotesbreastcancercellinvasion AT emmalinecbarnhill humansnorna93isprocessedintoamicrornalikernathatpromotesbreastcancercellinvasion AT alinecrucello humansnorna93isprocessedintoamicrornalikernathatpromotesbreastcancercellinvasion AT carolinejpolska humansnorna93isprocessedintoamicrornalikernathatpromotesbreastcancercellinvasion AT lucaswbrantley humansnorna93isprocessedintoamicrornalikernathatpromotesbreastcancercellinvasion AT garrettckaufman humansnorna93isprocessedintoamicrornalikernathatpromotesbreastcancercellinvasion AT michaelnguyen humansnorna93isprocessedintoamicrornalikernathatpromotesbreastcancercellinvasion AT megannwsantana humansnorna93isprocessedintoamicrornalikernathatpromotesbreastcancercellinvasion AT ianaschiller humansnorna93isprocessedintoamicrornalikernathatpromotesbreastcancercellinvasion AT juliussspicciani humansnorna93isprocessedintoamicrornalikernathatpromotesbreastcancercellinvasion AT anastasiakzapata humansnorna93isprocessedintoamicrornalikernathatpromotesbreastcancercellinvasion AT mollymmiller humansnorna93isprocessedintoamicrornalikernathatpromotesbreastcancercellinvasion AT timothydsherman humansnorna93isprocessedintoamicrornalikernathatpromotesbreastcancercellinvasion AT ruixiama humansnorna93isprocessedintoamicrornalikernathatpromotesbreastcancercellinvasion AT hongyouzhao humansnorna93isprocessedintoamicrornalikernathatpromotesbreastcancercellinvasion AT rituarora humansnorna93isprocessedintoamicrornalikernathatpromotesbreastcancercellinvasion AT alexanderbcoley humansnorna93isprocessedintoamicrornalikernathatpromotesbreastcancercellinvasion AT melodymzeidan humansnorna93isprocessedintoamicrornalikernathatpromotesbreastcancercellinvasion AT mingtan humansnorna93isprocessedintoamicrornalikernathatpromotesbreastcancercellinvasion AT yaguangxi humansnorna93isprocessedintoamicrornalikernathatpromotesbreastcancercellinvasion AT glenmborchert humansnorna93isprocessedintoamicrornalikernathatpromotesbreastcancercellinvasion
_version_	1718387457591869440

Human snoRNA-93 is processed into a microRNA-like RNA that promotes breast cancer cell invasion

Ejemplares similares