The C5a/C5a receptor 1 axis controls tissue neovascularization through CXCL4 release from platelets

The C5a/C5a receptor 1 axis controls tissue neovascularization through CXCL4 release from platelets

As more intersection points between platelets and the immune system are found, the role of platelets for vessel growth in the adult organism remains unclear. The authors demonstrate that platelets negatively modulate revascularization through CXCL4 secretion induced by activation C5aR1 on their surf...

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Autores principales: Henry Nording, Lasse Baron, David Haberthür, Frederic Emschermann, Matthias Mezger, Manuela Sauter, Reinhard Sauter, Johannes Patzelt, Kai Knoepp, Anne Nording, Moritz Meusel, Roza Meyer-Saraei, Ruslan Hlushchuk, Daniel Sedding, Oliver Borst, Ingo Eitel, Christian M. Karsten, Robert Feil, Bernd Pichler, Jeanette Erdmann, Admar Verschoor, Emmanouil Chavakis, Triantafyllos Chavakis, Philipp von Hundelshausen, Jörg Köhl, Meinrad Gawaz, Harald F. Langer
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/87faa2a159a0413296eadbb6d07bb8c0
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spelling oai:doaj.org-article:87faa2a159a0413296eadbb6d07bb8c02021-12-02T18:06:34ZThe C5a/C5a receptor 1 axis controls tissue neovascularization through CXCL4 release from platelets10.1038/s41467-021-23499-w2041-1723https://doaj.org/article/87faa2a159a0413296eadbb6d07bb8c02021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23499-whttps://doaj.org/toc/2041-1723As more intersection points between platelets and the immune system are found, the role of platelets for vessel growth in the adult organism remains unclear. The authors demonstrate that platelets negatively modulate revascularization through CXCL4 secretion induced by activation C5aR1 on their surface.Henry NordingLasse BaronDavid HaberthürFrederic EmschermannMatthias MezgerManuela SauterReinhard SauterJohannes PatzeltKai KnoeppAnne NordingMoritz MeuselRoza Meyer-SaraeiRuslan HlushchukDaniel SeddingOliver BorstIngo EitelChristian M. KarstenRobert FeilBernd PichlerJeanette ErdmannAdmar VerschoorEmmanouil ChavakisTriantafyllos ChavakisPhilipp von HundelshausenJörg KöhlMeinrad GawazHarald F. LangerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Henry Nording
Lasse Baron
David Haberthür
Frederic Emschermann
Matthias Mezger
Manuela Sauter
Reinhard Sauter
Johannes Patzelt
Kai Knoepp
Anne Nording
Moritz Meusel
Roza Meyer-Saraei
Ruslan Hlushchuk
Daniel Sedding
Oliver Borst
Ingo Eitel
Christian M. Karsten
Robert Feil
Bernd Pichler
Jeanette Erdmann
Admar Verschoor
Emmanouil Chavakis
Triantafyllos Chavakis
Philipp von Hundelshausen
Jörg Köhl
Meinrad Gawaz
Harald F. Langer
The C5a/C5a receptor 1 axis controls tissue neovascularization through CXCL4 release from platelets
description As more intersection points between platelets and the immune system are found, the role of platelets for vessel growth in the adult organism remains unclear. The authors demonstrate that platelets negatively modulate revascularization through CXCL4 secretion induced by activation C5aR1 on their surface.
format article
author Henry Nording
Lasse Baron
David Haberthür
Frederic Emschermann
Matthias Mezger
Manuela Sauter
Reinhard Sauter
Johannes Patzelt
Kai Knoepp
Anne Nording
Moritz Meusel
Roza Meyer-Saraei
Ruslan Hlushchuk
Daniel Sedding
Oliver Borst
Ingo Eitel
Christian M. Karsten
Robert Feil
Bernd Pichler
Jeanette Erdmann
Admar Verschoor
Emmanouil Chavakis
Triantafyllos Chavakis
Philipp von Hundelshausen
Jörg Köhl
Meinrad Gawaz
Harald F. Langer
author_facet Henry Nording
Lasse Baron
David Haberthür
Frederic Emschermann
Matthias Mezger
Manuela Sauter
Reinhard Sauter
Johannes Patzelt
Kai Knoepp
Anne Nording
Moritz Meusel
Roza Meyer-Saraei
Ruslan Hlushchuk
Daniel Sedding
Oliver Borst
Ingo Eitel
Christian M. Karsten
Robert Feil
Bernd Pichler
Jeanette Erdmann
Admar Verschoor
Emmanouil Chavakis
Triantafyllos Chavakis
Philipp von Hundelshausen
Jörg Köhl
Meinrad Gawaz
Harald F. Langer
author_sort Henry Nording
title The C5a/C5a receptor 1 axis controls tissue neovascularization through CXCL4 release from platelets
title_short The C5a/C5a receptor 1 axis controls tissue neovascularization through CXCL4 release from platelets
title_full The C5a/C5a receptor 1 axis controls tissue neovascularization through CXCL4 release from platelets
title_fullStr The C5a/C5a receptor 1 axis controls tissue neovascularization through CXCL4 release from platelets
title_full_unstemmed The C5a/C5a receptor 1 axis controls tissue neovascularization through CXCL4 release from platelets
title_sort c5a/c5a receptor 1 axis controls tissue neovascularization through cxcl4 release from platelets
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/87faa2a159a0413296eadbb6d07bb8c0
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