The action mechanism of the Myc inhibitor termed Omomyc may give clues on how to target Myc for cancer therapy.

Recent evidence points to Myc--a multifaceted bHLHZip transcription factor deregulated in the majority of human cancers--as a priority target for therapy. How to target Myc is less clear, given its involvement in a variety of key functions in healthy cells. Here we report on the action mechanism of...

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Autores principales: Mauro Savino, Daniela Annibali, Nicoletta Carucci, Emilia Favuzzi, Michael D Cole, Gerard I Evan, Laura Soucek, Sergio Nasi
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
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Acceso en línea:https://doaj.org/article/87fb9854901348e2bd4e187527a28c7e
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