A genome wide association study identifies common variants associated with lipid levels in the Chinese population.
Plasma lipid levels are important risk factors for cardiovascular disease and are influenced by genetic and environmental factors. Recent genome wide association studies (GWAS) have identified several lipid-associated loci, but these loci have been identified primarily in European populations. In or...
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2013
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oai:doaj.org-article:87fd049c824a457bb2c3734ac8864be92021-11-18T08:39:59ZA genome wide association study identifies common variants associated with lipid levels in the Chinese population.1932-620310.1371/journal.pone.0082420https://doaj.org/article/87fd049c824a457bb2c3734ac8864be92013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24386095/?tool=EBIhttps://doaj.org/toc/1932-6203Plasma lipid levels are important risk factors for cardiovascular disease and are influenced by genetic and environmental factors. Recent genome wide association studies (GWAS) have identified several lipid-associated loci, but these loci have been identified primarily in European populations. In order to identify genetic markers for lipid levels in a Chinese population and analyze the heterogeneity between Europeans and Asians, especially Chinese, we performed a meta-analysis of two genome wide association studies on four common lipid traits including total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL) and high-density lipoprotein cholesterol (HDL) in a Han Chinese population totaling 3,451 healthy subjects. Replication was performed in an additional 8,830 subjects of Han Chinese ethnicity. We replicated eight loci associated with lipid levels previously reported in a European population. The loci genome wide significantly associated with TC were near DOCK7, HMGCR and ABO; those genome wide significantly associated with TG were near APOA1/C3/A4/A5 and LPL; those genome wide significantly associated with LDL were near HMGCR, ABO and TOMM40; and those genome wide significantly associated with HDL were near LPL, LIPC and CETP. In addition, an additive genotype score of eight SNPs representing the eight loci that were found to be associated with lipid levels was associated with higher TC, TG and LDL levels (P = 5.52 × 10(-16), 1.38 × 10(-6) and 5.59 × 10(-9), respectively). These findings suggest the cumulative effects of multiple genetic loci on plasma lipid levels. Comparisons with previous GWAS of lipids highlight heterogeneity in allele frequency and in effect size for some loci between Chinese and European populations. The results from our GWAS provided comprehensive and convincing evidence of the genetic determinants of plasma lipid levels in a Chinese population.Li ZhouMeian HeZengnan MoChen WuHandong YangDianke YuXiaobo YangXiaomin ZhangYiqin WangJielin SunYong GaoAihua TanYunfeng HeHaiying ZhangXue QinJingwen ZhuHuaixing LiXu LinJiang ZhuXinwen MinMingjian LangDongfeng LiKan ZhaiJiang ChangWen TanJing YuanWeihong ChenYoujie WangSheng WeiXiaoping MiaoFeng WangWeimin FangYuan LiangQifei DengXiayun DaiDafeng LinSuli HuangHuan GuoS Lilly ZhengJianfeng XuDongxin LinFrank B HuTangchun WuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 12, p e82420 (2013) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Li Zhou Meian He Zengnan Mo Chen Wu Handong Yang Dianke Yu Xiaobo Yang Xiaomin Zhang Yiqin Wang Jielin Sun Yong Gao Aihua Tan Yunfeng He Haiying Zhang Xue Qin Jingwen Zhu Huaixing Li Xu Lin Jiang Zhu Xinwen Min Mingjian Lang Dongfeng Li Kan Zhai Jiang Chang Wen Tan Jing Yuan Weihong Chen Youjie Wang Sheng Wei Xiaoping Miao Feng Wang Weimin Fang Yuan Liang Qifei Deng Xiayun Dai Dafeng Lin Suli Huang Huan Guo S Lilly Zheng Jianfeng Xu Dongxin Lin Frank B Hu Tangchun Wu A genome wide association study identifies common variants associated with lipid levels in the Chinese population. |
| description |
Plasma lipid levels are important risk factors for cardiovascular disease and are influenced by genetic and environmental factors. Recent genome wide association studies (GWAS) have identified several lipid-associated loci, but these loci have been identified primarily in European populations. In order to identify genetic markers for lipid levels in a Chinese population and analyze the heterogeneity between Europeans and Asians, especially Chinese, we performed a meta-analysis of two genome wide association studies on four common lipid traits including total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL) and high-density lipoprotein cholesterol (HDL) in a Han Chinese population totaling 3,451 healthy subjects. Replication was performed in an additional 8,830 subjects of Han Chinese ethnicity. We replicated eight loci associated with lipid levels previously reported in a European population. The loci genome wide significantly associated with TC were near DOCK7, HMGCR and ABO; those genome wide significantly associated with TG were near APOA1/C3/A4/A5 and LPL; those genome wide significantly associated with LDL were near HMGCR, ABO and TOMM40; and those genome wide significantly associated with HDL were near LPL, LIPC and CETP. In addition, an additive genotype score of eight SNPs representing the eight loci that were found to be associated with lipid levels was associated with higher TC, TG and LDL levels (P = 5.52 × 10(-16), 1.38 × 10(-6) and 5.59 × 10(-9), respectively). These findings suggest the cumulative effects of multiple genetic loci on plasma lipid levels. Comparisons with previous GWAS of lipids highlight heterogeneity in allele frequency and in effect size for some loci between Chinese and European populations. The results from our GWAS provided comprehensive and convincing evidence of the genetic determinants of plasma lipid levels in a Chinese population. |
| format |
article |
| author |
Li Zhou Meian He Zengnan Mo Chen Wu Handong Yang Dianke Yu Xiaobo Yang Xiaomin Zhang Yiqin Wang Jielin Sun Yong Gao Aihua Tan Yunfeng He Haiying Zhang Xue Qin Jingwen Zhu Huaixing Li Xu Lin Jiang Zhu Xinwen Min Mingjian Lang Dongfeng Li Kan Zhai Jiang Chang Wen Tan Jing Yuan Weihong Chen Youjie Wang Sheng Wei Xiaoping Miao Feng Wang Weimin Fang Yuan Liang Qifei Deng Xiayun Dai Dafeng Lin Suli Huang Huan Guo S Lilly Zheng Jianfeng Xu Dongxin Lin Frank B Hu Tangchun Wu |
| author_facet |
Li Zhou Meian He Zengnan Mo Chen Wu Handong Yang Dianke Yu Xiaobo Yang Xiaomin Zhang Yiqin Wang Jielin Sun Yong Gao Aihua Tan Yunfeng He Haiying Zhang Xue Qin Jingwen Zhu Huaixing Li Xu Lin Jiang Zhu Xinwen Min Mingjian Lang Dongfeng Li Kan Zhai Jiang Chang Wen Tan Jing Yuan Weihong Chen Youjie Wang Sheng Wei Xiaoping Miao Feng Wang Weimin Fang Yuan Liang Qifei Deng Xiayun Dai Dafeng Lin Suli Huang Huan Guo S Lilly Zheng Jianfeng Xu Dongxin Lin Frank B Hu Tangchun Wu |
| author_sort |
Li Zhou |
| title |
A genome wide association study identifies common variants associated with lipid levels in the Chinese population. |
| title_short |
A genome wide association study identifies common variants associated with lipid levels in the Chinese population. |
| title_full |
A genome wide association study identifies common variants associated with lipid levels in the Chinese population. |
| title_fullStr |
A genome wide association study identifies common variants associated with lipid levels in the Chinese population. |
| title_full_unstemmed |
A genome wide association study identifies common variants associated with lipid levels in the Chinese population. |
| title_sort |
genome wide association study identifies common variants associated with lipid levels in the chinese population. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2013 |
| url |
https://doaj.org/article/87fd049c824a457bb2c3734ac8864be9 |
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