Adipocyte calcium sensing receptor is not involved in visceral adipose tissue inflammation or atherosclerosis development in hyperlipidemic Apoe −/− mice

Abstract The calcium sensing receptor (CaSR) is a G-protein coupled receptor that especially plays an important role in the sensing of extracellular calcium to maintain its homeostasis. Several in-vitro studies demonstrated that CaSR plays a role in adipose tissue metabolism and inflammation, result...

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Autores principales:	Sai Sahana Sundararaman, Linsey J. F. Peters, Yvonne Jansen, Selin Gencer, Yi Yan, Sumra Nazir, Andrea Bonnin Marquez, Florian Kahles, Michael Lehrke, Erik A. L. Biessen, Joachim Jankowski, Christian Weber, Yvonne Döring, Emiel P. C. van der Vorst
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/87fd70aad42849868f01443f6ec9d2fe
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spelling	oai:doaj.org-article:87fd70aad42849868f01443f6ec9d2fe2021-12-02T14:58:37ZAdipocyte calcium sensing receptor is not involved in visceral adipose tissue inflammation or atherosclerosis development in hyperlipidemic Apoe −/− mice10.1038/s41598-021-89893-y2045-2322https://doaj.org/article/87fd70aad42849868f01443f6ec9d2fe2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89893-yhttps://doaj.org/toc/2045-2322Abstract The calcium sensing receptor (CaSR) is a G-protein coupled receptor that especially plays an important role in the sensing of extracellular calcium to maintain its homeostasis. Several in-vitro studies demonstrated that CaSR plays a role in adipose tissue metabolism and inflammation, resulting in systemic inflammation and contributing to atherosclerosis development. The aim of this study was to investigate whether adipocyte CaSR plays a role in adipose tissue inflammation in-vivo and atherosclerosis development. By using a newly established conditional mature adipocyte specific CaSR deficient mouse on a hyperlipidemic and atherosclerosis prone Apoe −/− background it could be shown that CaSR deficiency in adipocytes does neither contribute to initiation nor to progression of atherosclerotic plaques as judged by the unchanged lesion size or composition. Additionally, CaSR deficiency did not influence gonadal visceral adipose tissue (vAT) inflammation in-vivo, although a small decrease in gonadal visceral adipose cholesterol content could be observed. In conclusion, adipocyte CaSR seems not to be involved in vAT inflammation in-vivo and does not influence atherosclerosis development in hyperlipidemic Apoe−/− mice.Sai Sahana SundararamanLinsey J. F. PetersYvonne JansenSelin GencerYi YanSumra NazirAndrea Bonnin MarquezFlorian KahlesMichael LehrkeErik A. L. BiessenJoachim JankowskiChristian WeberYvonne DöringEmiel P. C. van der VorstNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sai Sahana Sundararaman Linsey J. F. Peters Yvonne Jansen Selin Gencer Yi Yan Sumra Nazir Andrea Bonnin Marquez Florian Kahles Michael Lehrke Erik A. L. Biessen Joachim Jankowski Christian Weber Yvonne Döring Emiel P. C. van der Vorst Adipocyte calcium sensing receptor is not involved in visceral adipose tissue inflammation or atherosclerosis development in hyperlipidemic Apoe −/− mice
description	Abstract The calcium sensing receptor (CaSR) is a G-protein coupled receptor that especially plays an important role in the sensing of extracellular calcium to maintain its homeostasis. Several in-vitro studies demonstrated that CaSR plays a role in adipose tissue metabolism and inflammation, resulting in systemic inflammation and contributing to atherosclerosis development. The aim of this study was to investigate whether adipocyte CaSR plays a role in adipose tissue inflammation in-vivo and atherosclerosis development. By using a newly established conditional mature adipocyte specific CaSR deficient mouse on a hyperlipidemic and atherosclerosis prone Apoe −/− background it could be shown that CaSR deficiency in adipocytes does neither contribute to initiation nor to progression of atherosclerotic plaques as judged by the unchanged lesion size or composition. Additionally, CaSR deficiency did not influence gonadal visceral adipose tissue (vAT) inflammation in-vivo, although a small decrease in gonadal visceral adipose cholesterol content could be observed. In conclusion, adipocyte CaSR seems not to be involved in vAT inflammation in-vivo and does not influence atherosclerosis development in hyperlipidemic Apoe−/− mice.
format	article
author	Sai Sahana Sundararaman Linsey J. F. Peters Yvonne Jansen Selin Gencer Yi Yan Sumra Nazir Andrea Bonnin Marquez Florian Kahles Michael Lehrke Erik A. L. Biessen Joachim Jankowski Christian Weber Yvonne Döring Emiel P. C. van der Vorst
author_facet	Sai Sahana Sundararaman Linsey J. F. Peters Yvonne Jansen Selin Gencer Yi Yan Sumra Nazir Andrea Bonnin Marquez Florian Kahles Michael Lehrke Erik A. L. Biessen Joachim Jankowski Christian Weber Yvonne Döring Emiel P. C. van der Vorst
author_sort	Sai Sahana Sundararaman
title	Adipocyte calcium sensing receptor is not involved in visceral adipose tissue inflammation or atherosclerosis development in hyperlipidemic Apoe −/− mice
title_short	Adipocyte calcium sensing receptor is not involved in visceral adipose tissue inflammation or atherosclerosis development in hyperlipidemic Apoe −/− mice
title_full	Adipocyte calcium sensing receptor is not involved in visceral adipose tissue inflammation or atherosclerosis development in hyperlipidemic Apoe −/− mice
title_fullStr	Adipocyte calcium sensing receptor is not involved in visceral adipose tissue inflammation or atherosclerosis development in hyperlipidemic Apoe −/− mice
title_full_unstemmed	Adipocyte calcium sensing receptor is not involved in visceral adipose tissue inflammation or atherosclerosis development in hyperlipidemic Apoe −/− mice
title_sort	adipocyte calcium sensing receptor is not involved in visceral adipose tissue inflammation or atherosclerosis development in hyperlipidemic apoe −/− mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/87fd70aad42849868f01443f6ec9d2fe
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Adipocyte calcium sensing receptor is not involved in visceral adipose tissue inflammation or atherosclerosis development in hyperlipidemic Apoe −/− mice

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