Inhibition of neuronal FLT3 receptor tyrosine kinase alleviates peripheral neuropathic pain in mice
Sensitisation of dorsal root ganglia neurons contributes to neuropathic pain. Here the authors demonstrate the cytokine FL contributes to sensitisation of DRGs via its receptor FLT3 expressed on neurons, and identify a novel FLT3 inhibitor that attenuates neuropathic pain in mice.
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Nature Portfolio
2018
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oai:doaj.org-article:87fd7efd827f43ad990381c8a9541b422021-12-02T16:56:40ZInhibition of neuronal FLT3 receptor tyrosine kinase alleviates peripheral neuropathic pain in mice10.1038/s41467-018-03496-22041-1723https://doaj.org/article/87fd7efd827f43ad990381c8a9541b422018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03496-2https://doaj.org/toc/2041-1723Sensitisation of dorsal root ganglia neurons contributes to neuropathic pain. Here the authors demonstrate the cytokine FL contributes to sensitisation of DRGs via its receptor FLT3 expressed on neurons, and identify a novel FLT3 inhibitor that attenuates neuropathic pain in mice.Cyril RivatChamroeun SarIlana MechalyJean-Philippe LeyrisLucie DiouloufetCorinne SonrierYann PhilipsonOlivier LucasSylvie MalliéAntoine JouvenelAdrien TassouHenri HatonStéphanie VenteoJean-Philippe PinEric TrinquetFabienne Charrier-SavourninAlexandre MezghraniWilly JolyJulie MionMartine SchmittAlexandre PattynFrédéric MarmigèrePierre SokoloffPatrick CarrollDidier RognanJean ValmierNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018) |
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Science Q Cyril Rivat Chamroeun Sar Ilana Mechaly Jean-Philippe Leyris Lucie Diouloufet Corinne Sonrier Yann Philipson Olivier Lucas Sylvie Mallié Antoine Jouvenel Adrien Tassou Henri Haton Stéphanie Venteo Jean-Philippe Pin Eric Trinquet Fabienne Charrier-Savournin Alexandre Mezghrani Willy Joly Julie Mion Martine Schmitt Alexandre Pattyn Frédéric Marmigère Pierre Sokoloff Patrick Carroll Didier Rognan Jean Valmier Inhibition of neuronal FLT3 receptor tyrosine kinase alleviates peripheral neuropathic pain in mice |
| description |
Sensitisation of dorsal root ganglia neurons contributes to neuropathic pain. Here the authors demonstrate the cytokine FL contributes to sensitisation of DRGs via its receptor FLT3 expressed on neurons, and identify a novel FLT3 inhibitor that attenuates neuropathic pain in mice. |
| format |
article |
| author |
Cyril Rivat Chamroeun Sar Ilana Mechaly Jean-Philippe Leyris Lucie Diouloufet Corinne Sonrier Yann Philipson Olivier Lucas Sylvie Mallié Antoine Jouvenel Adrien Tassou Henri Haton Stéphanie Venteo Jean-Philippe Pin Eric Trinquet Fabienne Charrier-Savournin Alexandre Mezghrani Willy Joly Julie Mion Martine Schmitt Alexandre Pattyn Frédéric Marmigère Pierre Sokoloff Patrick Carroll Didier Rognan Jean Valmier |
| author_facet |
Cyril Rivat Chamroeun Sar Ilana Mechaly Jean-Philippe Leyris Lucie Diouloufet Corinne Sonrier Yann Philipson Olivier Lucas Sylvie Mallié Antoine Jouvenel Adrien Tassou Henri Haton Stéphanie Venteo Jean-Philippe Pin Eric Trinquet Fabienne Charrier-Savournin Alexandre Mezghrani Willy Joly Julie Mion Martine Schmitt Alexandre Pattyn Frédéric Marmigère Pierre Sokoloff Patrick Carroll Didier Rognan Jean Valmier |
| author_sort |
Cyril Rivat |
| title |
Inhibition of neuronal FLT3 receptor tyrosine kinase alleviates peripheral neuropathic pain in mice |
| title_short |
Inhibition of neuronal FLT3 receptor tyrosine kinase alleviates peripheral neuropathic pain in mice |
| title_full |
Inhibition of neuronal FLT3 receptor tyrosine kinase alleviates peripheral neuropathic pain in mice |
| title_fullStr |
Inhibition of neuronal FLT3 receptor tyrosine kinase alleviates peripheral neuropathic pain in mice |
| title_full_unstemmed |
Inhibition of neuronal FLT3 receptor tyrosine kinase alleviates peripheral neuropathic pain in mice |
| title_sort |
inhibition of neuronal flt3 receptor tyrosine kinase alleviates peripheral neuropathic pain in mice |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/87fd7efd827f43ad990381c8a9541b42 |
| work_keys_str_mv |
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1718382751558664192 |