Handgrip Strength: Associations with Clinical Variables, Body Composition, and Bone Mineral Density in Adults with Cystic Fibrosis

Background: Loss of fat-free mass (FFM) is associated with an increase in morbidity and mortality in cystic fibrosis (CF) patients. Handgrip strength (HGS) measures muscle function and may be associated with clinical parameters with prognostic value. Our objectives were to evaluate muscle strength t...

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Autores principales:	Victoria Contreras-Bolívar, Casilda Olveira, Ignacio Ruiz-García, Nuria Porras, Maria García-Olivares, Francisco José Sánchez-Torralvo, Maria Victoria Girón, Silvia P. Alonso-Gallardo, Gabriel Olveira
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cystic fibrosis handgrip strength Jamar handgrip dynamometry malnutrition nutritional assessment Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/88032d406b054abab0eafb476cdf51d6
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spelling	oai:doaj.org-article:88032d406b054abab0eafb476cdf51d62021-11-25T18:36:48ZHandgrip Strength: Associations with Clinical Variables, Body Composition, and Bone Mineral Density in Adults with Cystic Fibrosis10.3390/nu131141072072-6643https://doaj.org/article/88032d406b054abab0eafb476cdf51d62021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/4107https://doaj.org/toc/2072-6643Background: Loss of fat-free mass (FFM) is associated with an increase in morbidity and mortality in cystic fibrosis (CF) patients. Handgrip strength (HGS) measures muscle function and may be associated with clinical parameters with prognostic value. Our objectives were to evaluate muscle strength through HGS in CF patients and to determine if there are any associations with respiratory clinical variables, FFM, and bone mineral density (BMD). Methods: A cross-sectional study conducted in clinically stable patients. We evaluated muscle function through HGS, respiratory function—forced expiratory volume in 1 s (FEV1) (%), forced vital capacity (FVC) (%), bronchorrhea, annual exacerbations, and body composition (FFM and FFM index, FFMI: fat-free mass in kg/height in m<sup>2</sup>) and Bone Mineral Density (BMD) through densitometry (DXA). Results: The study included 53 CF patients (58.5% females, mean age 28.3 ± 8.1, body mass index (BMI) 21.7 ± 3.4). The mean values for dynamometry were 40.2 ± 8.1 kg in males and 23.1 ± 7.0 kg in women, being 20.8% below the 10th percentile. Patients with lower muscle strength showed significantly more exacerbations and lower FEV1% and FVC%, as well as lower BMI, worse BMD (g/cm<sup>2</sup>), T-score, and Z-score. A significant and positive correlation was found between the mean and maximum dynamometry values and age, FVC%, BMI, FFMI, FFM (kg), and BMD. Conclusions: For adults with CF, HGS is a practical tool for assessment of health status. Low values reflect poor nutritional status and are associated with poor respiratory function, low fat-free mass and low bone mineral density.Victoria Contreras-BolívarCasilda OlveiraIgnacio Ruiz-GarcíaNuria PorrasMaria García-OlivaresFrancisco José Sánchez-TorralvoMaria Victoria GirónSilvia P. Alonso-GallardoGabriel OlveiraMDPI AGarticlecystic fibrosishandgrip strengthJamar handgrip dynamometrymalnutritionnutritional assessmentNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 4107, p 4107 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cystic fibrosis handgrip strength Jamar handgrip dynamometry malnutrition nutritional assessment Nutrition. Foods and food supply TX341-641
spellingShingle	cystic fibrosis handgrip strength Jamar handgrip dynamometry malnutrition nutritional assessment Nutrition. Foods and food supply TX341-641 Victoria Contreras-Bolívar Casilda Olveira Ignacio Ruiz-García Nuria Porras Maria García-Olivares Francisco José Sánchez-Torralvo Maria Victoria Girón Silvia P. Alonso-Gallardo Gabriel Olveira Handgrip Strength: Associations with Clinical Variables, Body Composition, and Bone Mineral Density in Adults with Cystic Fibrosis
description	Background: Loss of fat-free mass (FFM) is associated with an increase in morbidity and mortality in cystic fibrosis (CF) patients. Handgrip strength (HGS) measures muscle function and may be associated with clinical parameters with prognostic value. Our objectives were to evaluate muscle strength through HGS in CF patients and to determine if there are any associations with respiratory clinical variables, FFM, and bone mineral density (BMD). Methods: A cross-sectional study conducted in clinically stable patients. We evaluated muscle function through HGS, respiratory function—forced expiratory volume in 1 s (FEV1) (%), forced vital capacity (FVC) (%), bronchorrhea, annual exacerbations, and body composition (FFM and FFM index, FFMI: fat-free mass in kg/height in m<sup>2</sup>) and Bone Mineral Density (BMD) through densitometry (DXA). Results: The study included 53 CF patients (58.5% females, mean age 28.3 ± 8.1, body mass index (BMI) 21.7 ± 3.4). The mean values for dynamometry were 40.2 ± 8.1 kg in males and 23.1 ± 7.0 kg in women, being 20.8% below the 10th percentile. Patients with lower muscle strength showed significantly more exacerbations and lower FEV1% and FVC%, as well as lower BMI, worse BMD (g/cm<sup>2</sup>), T-score, and Z-score. A significant and positive correlation was found between the mean and maximum dynamometry values and age, FVC%, BMI, FFMI, FFM (kg), and BMD. Conclusions: For adults with CF, HGS is a practical tool for assessment of health status. Low values reflect poor nutritional status and are associated with poor respiratory function, low fat-free mass and low bone mineral density.
format	article
author	Victoria Contreras-Bolívar Casilda Olveira Ignacio Ruiz-García Nuria Porras Maria García-Olivares Francisco José Sánchez-Torralvo Maria Victoria Girón Silvia P. Alonso-Gallardo Gabriel Olveira
author_facet	Victoria Contreras-Bolívar Casilda Olveira Ignacio Ruiz-García Nuria Porras Maria García-Olivares Francisco José Sánchez-Torralvo Maria Victoria Girón Silvia P. Alonso-Gallardo Gabriel Olveira
author_sort	Victoria Contreras-Bolívar
title	Handgrip Strength: Associations with Clinical Variables, Body Composition, and Bone Mineral Density in Adults with Cystic Fibrosis
title_short	Handgrip Strength: Associations with Clinical Variables, Body Composition, and Bone Mineral Density in Adults with Cystic Fibrosis
title_full	Handgrip Strength: Associations with Clinical Variables, Body Composition, and Bone Mineral Density in Adults with Cystic Fibrosis
title_fullStr	Handgrip Strength: Associations with Clinical Variables, Body Composition, and Bone Mineral Density in Adults with Cystic Fibrosis
title_full_unstemmed	Handgrip Strength: Associations with Clinical Variables, Body Composition, and Bone Mineral Density in Adults with Cystic Fibrosis
title_sort	handgrip strength: associations with clinical variables, body composition, and bone mineral density in adults with cystic fibrosis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/88032d406b054abab0eafb476cdf51d6
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Handgrip Strength: Associations with Clinical Variables, Body Composition, and Bone Mineral Density in Adults with Cystic Fibrosis

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