Inadequate Vaccine Responses in Children With Multiple Sclerosis

Objective: Immunizations against Hepatitis B virus (HBV) and Varicella Zoster virus (VZV), are recommended for patients with pediatric onset multiple sclerosis (POMS) and may be required prior to initiation of some disease modifying therapies. However, the efficacy of routine vaccine administration...

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Autores principales:	Jonathan D. Santoro, Laura E. Saucier, Runi Tanna, Sarah E. Wiegand, Dania Pagarkar, Adam F. Tempchin, Mellad Khoshnood, Nusrat Ahsan, Keith Van Haren
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	multiple sclerosis pediatric vaccine vaccine response immunology and infectious diseases Pediatrics RJ1-570
Acceso en línea:	https://doaj.org/article/8807abdef2c54fd78e8abecd47e05643
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spelling	oai:doaj.org-article:8807abdef2c54fd78e8abecd47e056432021-12-03T10:49:22ZInadequate Vaccine Responses in Children With Multiple Sclerosis2296-236010.3389/fped.2021.790159https://doaj.org/article/8807abdef2c54fd78e8abecd47e056432021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fped.2021.790159/fullhttps://doaj.org/toc/2296-2360Objective: Immunizations against Hepatitis B virus (HBV) and Varicella Zoster virus (VZV), are recommended for patients with pediatric onset multiple sclerosis (POMS) and may be required prior to initiation of some disease modifying therapies. However, the efficacy of routine vaccine administration in POMS has never been studied. We sought to assess the humoral mediated vaccine response to HBV and VZV in children with POMS.Methods: A multi-center retrospective chart-based review of 62 patients with POMS was performed. Clinical data and antibody titers against HBV and VZV were collected prior to initiation of disease modifying therapy or steroids and compared to institutional control data, using t-test and chi squared analysis.Results: There were low rates of immunity against both HBV and VZV (33 and 25% respectively) among individuals with POMS. Fifteen individuals (24%) were non-immune to both. Compared to institutional control data, individuals with POMS were significantly less likely to be immune to and HBV (p = 0.003, 95% CI: 0.22–0.75) and VZV (p < 0.001, 95% CI: 0.09–0.39).Interpretation: Individuals with POMS have low rates of antibody-mediated immunity against HBV and VZV, despite receiving the appropriate vaccinations. This suggests an association between POMS and systemic immune dysregulation although further study is needed.Jonathan D. SantoroJonathan D. SantoroLaura E. SaucierRuni TannaSarah E. WiegandDania PagarkarAdam F. TempchinMellad KhoshnoodNusrat AhsanNusrat AhsanKeith Van HarenFrontiers Media S.A.articlemultiple sclerosispediatricvaccinevaccine responseimmunology and infectious diseasesPediatricsRJ1-570ENFrontiers in Pediatrics, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	multiple sclerosis pediatric vaccine vaccine response immunology and infectious diseases Pediatrics RJ1-570
spellingShingle	multiple sclerosis pediatric vaccine vaccine response immunology and infectious diseases Pediatrics RJ1-570 Jonathan D. Santoro Jonathan D. Santoro Laura E. Saucier Runi Tanna Sarah E. Wiegand Dania Pagarkar Adam F. Tempchin Mellad Khoshnood Nusrat Ahsan Nusrat Ahsan Keith Van Haren Inadequate Vaccine Responses in Children With Multiple Sclerosis
description	Objective: Immunizations against Hepatitis B virus (HBV) and Varicella Zoster virus (VZV), are recommended for patients with pediatric onset multiple sclerosis (POMS) and may be required prior to initiation of some disease modifying therapies. However, the efficacy of routine vaccine administration in POMS has never been studied. We sought to assess the humoral mediated vaccine response to HBV and VZV in children with POMS.Methods: A multi-center retrospective chart-based review of 62 patients with POMS was performed. Clinical data and antibody titers against HBV and VZV were collected prior to initiation of disease modifying therapy or steroids and compared to institutional control data, using t-test and chi squared analysis.Results: There were low rates of immunity against both HBV and VZV (33 and 25% respectively) among individuals with POMS. Fifteen individuals (24%) were non-immune to both. Compared to institutional control data, individuals with POMS were significantly less likely to be immune to and HBV (p = 0.003, 95% CI: 0.22–0.75) and VZV (p < 0.001, 95% CI: 0.09–0.39).Interpretation: Individuals with POMS have low rates of antibody-mediated immunity against HBV and VZV, despite receiving the appropriate vaccinations. This suggests an association between POMS and systemic immune dysregulation although further study is needed.
format	article
author	Jonathan D. Santoro Jonathan D. Santoro Laura E. Saucier Runi Tanna Sarah E. Wiegand Dania Pagarkar Adam F. Tempchin Mellad Khoshnood Nusrat Ahsan Nusrat Ahsan Keith Van Haren
author_facet	Jonathan D. Santoro Jonathan D. Santoro Laura E. Saucier Runi Tanna Sarah E. Wiegand Dania Pagarkar Adam F. Tempchin Mellad Khoshnood Nusrat Ahsan Nusrat Ahsan Keith Van Haren
author_sort	Jonathan D. Santoro
title	Inadequate Vaccine Responses in Children With Multiple Sclerosis
title_short	Inadequate Vaccine Responses in Children With Multiple Sclerosis
title_full	Inadequate Vaccine Responses in Children With Multiple Sclerosis
title_fullStr	Inadequate Vaccine Responses in Children With Multiple Sclerosis
title_full_unstemmed	Inadequate Vaccine Responses in Children With Multiple Sclerosis
title_sort	inadequate vaccine responses in children with multiple sclerosis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/8807abdef2c54fd78e8abecd47e05643
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Inadequate Vaccine Responses in Children With Multiple Sclerosis

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