Depression and frailty in later life: a systematic review

Leslie Vaughan,1 Akeesha L Corbin,1 Joseph S Goveas2 1Department of Social Sciences and Health Policy, Wake Forest School of Medicine, Winston-Salem, NC, USA; 2Department of Psychiatry and Behavioral Medicine, Medical College of Wisconsin, MI, USA Abstract: Frailty and depression are important iss...

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Autores principales:	Vaughan L, Corbin AL, Goveas JS
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Frailty Depressive Symptomatology Depression Aging Review Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/8807f75cf4c5458ab3b78bba5cd1ad25
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spelling	oai:doaj.org-article:8807f75cf4c5458ab3b78bba5cd1ad252021-12-02T00:05:22ZDepression and frailty in later life: a systematic review1178-1998https://doaj.org/article/8807f75cf4c5458ab3b78bba5cd1ad252015-12-01T00:00:00Zhttps://www.dovepress.com/depression-and-frailty-in-later-life-a-systematic-review-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Leslie Vaughan,1 Akeesha L Corbin,1 Joseph S Goveas2 1Department of Social Sciences and Health Policy, Wake Forest School of Medicine, Winston-Salem, NC, USA; 2Department of Psychiatry and Behavioral Medicine, Medical College of Wisconsin, MI, USA Abstract: Frailty and depression are important issues affecting older adults. Depressive syndrome may be difficult to clinically disambiguate from frailty in advanced old age. Current reviews on the topic include studies with wide methodological variation. This review examined the published literature on cross-sectional and longitudinal associations between frailty and depressive symptomatology with either syndrome as the outcome, moderators of this relationship, construct overlap, and related medical and behavioral interventions. Prevalence of both was reported. A systematic review of studies published from 2000 to 2015 was conducted in PubMed, the Cochrane Database of Systematic Reviews, and PsychInfo. Key search terms were “frailty”, “frail”, “frail elderly”, “depressive”, “depressive disorder”, and “depression”. Participants of included studies were ≥55 years old and community dwelling. Included studies used an explicit biological definition of frailty based on Fried et al’s criteria and a screening measure to identify depressive symptomatology. Fourteen studies met the inclusion/exclusion criteria. The prevalence of depressive symptomatology, frailty, or their co-occurrence was greater than 10% in older adults ≥55 years old, and these rates varied widely, but less in large epidemiological studies of incident frailty. The prospective relationship between depressive symptomatology and increased risk of incident frailty was robust, while the opposite relationship was less conclusive. The presence of comorbidities that interact with depressive symptomatology increased incident frailty risk. Measurement variability of depressive symptomatology and inclusion of older adults who are severely depressed, have cognitive impairment or dementia, or stroke may confound the frailty syndrome with single disease outcomes, accounting for a substantial proportion of shared variance in the syndromes. Further study is needed to identify medical and behavioral interventions for frailty and depressive symptomatology that prevent adverse sequelae such as falls, disability, and premature mortality. Keywords: frailty, depression, depressive symptomatology, agingVaughan LCorbin ALGoveas JSDove Medical PressarticleFrailtyDepressive SymptomatologyDepressionAgingReviewGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 10, Pp 1947-1958 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Frailty Depressive Symptomatology Depression Aging Review Geriatrics RC952-954.6
spellingShingle	Frailty Depressive Symptomatology Depression Aging Review Geriatrics RC952-954.6 Vaughan L Corbin AL Goveas JS Depression and frailty in later life: a systematic review
description	Leslie Vaughan,1 Akeesha L Corbin,1 Joseph S Goveas2 1Department of Social Sciences and Health Policy, Wake Forest School of Medicine, Winston-Salem, NC, USA; 2Department of Psychiatry and Behavioral Medicine, Medical College of Wisconsin, MI, USA Abstract: Frailty and depression are important issues affecting older adults. Depressive syndrome may be difficult to clinically disambiguate from frailty in advanced old age. Current reviews on the topic include studies with wide methodological variation. This review examined the published literature on cross-sectional and longitudinal associations between frailty and depressive symptomatology with either syndrome as the outcome, moderators of this relationship, construct overlap, and related medical and behavioral interventions. Prevalence of both was reported. A systematic review of studies published from 2000 to 2015 was conducted in PubMed, the Cochrane Database of Systematic Reviews, and PsychInfo. Key search terms were “frailty”, “frail”, “frail elderly”, “depressive”, “depressive disorder”, and “depression”. Participants of included studies were ≥55 years old and community dwelling. Included studies used an explicit biological definition of frailty based on Fried et al’s criteria and a screening measure to identify depressive symptomatology. Fourteen studies met the inclusion/exclusion criteria. The prevalence of depressive symptomatology, frailty, or their co-occurrence was greater than 10% in older adults ≥55 years old, and these rates varied widely, but less in large epidemiological studies of incident frailty. The prospective relationship between depressive symptomatology and increased risk of incident frailty was robust, while the opposite relationship was less conclusive. The presence of comorbidities that interact with depressive symptomatology increased incident frailty risk. Measurement variability of depressive symptomatology and inclusion of older adults who are severely depressed, have cognitive impairment or dementia, or stroke may confound the frailty syndrome with single disease outcomes, accounting for a substantial proportion of shared variance in the syndromes. Further study is needed to identify medical and behavioral interventions for frailty and depressive symptomatology that prevent adverse sequelae such as falls, disability, and premature mortality. Keywords: frailty, depression, depressive symptomatology, aging
format	article
author	Vaughan L Corbin AL Goveas JS
author_facet	Vaughan L Corbin AL Goveas JS
author_sort	Vaughan L
title	Depression and frailty in later life: a systematic review
title_short	Depression and frailty in later life: a systematic review
title_full	Depression and frailty in later life: a systematic review
title_fullStr	Depression and frailty in later life: a systematic review
title_full_unstemmed	Depression and frailty in later life: a systematic review
title_sort	depression and frailty in later life: a systematic review
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/8807f75cf4c5458ab3b78bba5cd1ad25
work_keys_str_mv	AT vaughanl depressionandfrailtyinlaterlifeasystematicreview AT corbinal depressionandfrailtyinlaterlifeasystematicreview AT goveasjs depressionandfrailtyinlaterlifeasystematicreview
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Depression and frailty in later life: a systematic review

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