Comparative transcriptome analysis revealed omnivorous adaptation of the small intestine of Melinae

Abstract As the main digestive organ, the small intestine plays a vital role in the digestion of animals. At present, most of the research on animal feeding habits focuses on carnivores and herbivores. However, the mechanism of feeding and digestion in omnivores remains unclear. This study aims to r...

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Autores principales:	Lidong Wang, Xiufeng Yang, Shengyang Zhou, Tianshu Lyu, Lupeng Shi, Yuehuan Dong, Honghai Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8809a45f7dfa4f55ac6d85c47247a3c5
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spelling	oai:doaj.org-article:8809a45f7dfa4f55ac6d85c47247a3c52021-12-02T17:17:40ZComparative transcriptome analysis revealed omnivorous adaptation of the small intestine of Melinae10.1038/s41598-021-98561-02045-2322https://doaj.org/article/8809a45f7dfa4f55ac6d85c47247a3c52021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98561-0https://doaj.org/toc/2045-2322Abstract As the main digestive organ, the small intestine plays a vital role in the digestion of animals. At present, most of the research on animal feeding habits focuses on carnivores and herbivores. However, the mechanism of feeding and digestion in omnivores remains unclear. This study aims to reveal the molecular basis of the omnivorous adaptive evolution of Melinae by comparing the transcriptome of the small intestines of Asian Badgers (Meles leucurus) and Northern Hog Badgers (Arctonyx albogularis). We obtained high-quality small intestinal transcriptome data from these two species. Key genes and signalling pathways were analysed through Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) and other databases. Research has mainly found that orthologous genes related to six enzymes have undergone adaptive evolution. In addition, the study also found three digestion-related pathways (cGMP-PKG, cAMP, and Hippo). They are related to the digestion and absorption of nutrients, the secretion of intestinal fluids, and the transport of food through the small intestine, which may help omnivorous animals adapt to an omnivorous diet. Our study provides insight into the adaptation of Melinae to omnivores and affords a valuable transcriptome resource for future research.Lidong WangXiufeng YangShengyang ZhouTianshu LyuLupeng ShiYuehuan DongHonghai ZhangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lidong Wang Xiufeng Yang Shengyang Zhou Tianshu Lyu Lupeng Shi Yuehuan Dong Honghai Zhang Comparative transcriptome analysis revealed omnivorous adaptation of the small intestine of Melinae
description	Abstract As the main digestive organ, the small intestine plays a vital role in the digestion of animals. At present, most of the research on animal feeding habits focuses on carnivores and herbivores. However, the mechanism of feeding and digestion in omnivores remains unclear. This study aims to reveal the molecular basis of the omnivorous adaptive evolution of Melinae by comparing the transcriptome of the small intestines of Asian Badgers (Meles leucurus) and Northern Hog Badgers (Arctonyx albogularis). We obtained high-quality small intestinal transcriptome data from these two species. Key genes and signalling pathways were analysed through Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) and other databases. Research has mainly found that orthologous genes related to six enzymes have undergone adaptive evolution. In addition, the study also found three digestion-related pathways (cGMP-PKG, cAMP, and Hippo). They are related to the digestion and absorption of nutrients, the secretion of intestinal fluids, and the transport of food through the small intestine, which may help omnivorous animals adapt to an omnivorous diet. Our study provides insight into the adaptation of Melinae to omnivores and affords a valuable transcriptome resource for future research.
format	article
author	Lidong Wang Xiufeng Yang Shengyang Zhou Tianshu Lyu Lupeng Shi Yuehuan Dong Honghai Zhang
author_facet	Lidong Wang Xiufeng Yang Shengyang Zhou Tianshu Lyu Lupeng Shi Yuehuan Dong Honghai Zhang
author_sort	Lidong Wang
title	Comparative transcriptome analysis revealed omnivorous adaptation of the small intestine of Melinae
title_short	Comparative transcriptome analysis revealed omnivorous adaptation of the small intestine of Melinae
title_full	Comparative transcriptome analysis revealed omnivorous adaptation of the small intestine of Melinae
title_fullStr	Comparative transcriptome analysis revealed omnivorous adaptation of the small intestine of Melinae
title_full_unstemmed	Comparative transcriptome analysis revealed omnivorous adaptation of the small intestine of Melinae
title_sort	comparative transcriptome analysis revealed omnivorous adaptation of the small intestine of melinae
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8809a45f7dfa4f55ac6d85c47247a3c5
work_keys_str_mv	AT lidongwang comparativetranscriptomeanalysisrevealedomnivorousadaptationofthesmallintestineofmelinae AT xiufengyang comparativetranscriptomeanalysisrevealedomnivorousadaptationofthesmallintestineofmelinae AT shengyangzhou comparativetranscriptomeanalysisrevealedomnivorousadaptationofthesmallintestineofmelinae AT tianshulyu comparativetranscriptomeanalysisrevealedomnivorousadaptationofthesmallintestineofmelinae AT lupengshi comparativetranscriptomeanalysisrevealedomnivorousadaptationofthesmallintestineofmelinae AT yuehuandong comparativetranscriptomeanalysisrevealedomnivorousadaptationofthesmallintestineofmelinae AT honghaizhang comparativetranscriptomeanalysisrevealedomnivorousadaptationofthesmallintestineofmelinae
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Comparative transcriptome analysis revealed omnivorous adaptation of the small intestine of Melinae

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