Altered cortical bone strength and lean mass in young women with long-duration (19 years) type 1 diabetes

Abstract To investigate bone health and body composition in young women with long-duration type 1 diabetes (T1D) in relation to matched controls. Twenty-three Swedish women, age 19.2–27.9 years, with a T1D duration of 10 years or more were recruited from the Swedish National Diabetes Registry (NDR)....

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Autores principales:	Daniel Novak, Gun Forsander, Eva Kristiansen, Anna Svedlund, Per Magnusson, Diana Swolin-Eide
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/880c3cf88ad94bf59b5211388ba8c63f
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spelling	oai:doaj.org-article:880c3cf88ad94bf59b5211388ba8c63f2021-12-02T13:57:01ZAltered cortical bone strength and lean mass in young women with long-duration (19 years) type 1 diabetes10.1038/s41598-020-78853-72045-2322https://doaj.org/article/880c3cf88ad94bf59b5211388ba8c63f2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78853-7https://doaj.org/toc/2045-2322Abstract To investigate bone health and body composition in young women with long-duration type 1 diabetes (T1D) in relation to matched controls. Twenty-three Swedish women, age 19.2–27.9 years, with a T1D duration of 10 years or more were recruited from the Swedish National Diabetes Registry (NDR). An age-, gender- and geography-matched control group was recruited. Bone mass and body composition were assessed by dual-energy X-ray absorptiometry and peripheral quantitative computed tomography. Data was retrieved from the NDR and SWEDIABKIDS registries. T1D individuals had a mean diabetes duration of 19 years. T1D individuals had reduced lean mass (40.0 ± 6.1 kg vs. 43.9 ± 4.9 kg) and were shorter (1.66 ± 0.06 m vs. 1.71 ± 0.06 m) although comparable BMI. Subjects with T1D had lower muscle area (P = 0.0045). No differences were observed for fractures; physical activity; total, lumbar spine or femur areal bone mineral density. The cortical bone strength strain index was lower for TD1 patients (1875 ± 399 mm3 vs. 2277 ± 332 mm3). In conclusion, young women with long-term diabetes duration showed reduced cortical bone strength, decreased periosteal circumference, endosteal circumference and altered body composition. These factors contribute to the health burden of TD1, which warrants further attention for advancing bone health in women with T1D.Daniel NovakGun ForsanderEva KristiansenAnna SvedlundPer MagnussonDiana Swolin-EideNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Daniel Novak Gun Forsander Eva Kristiansen Anna Svedlund Per Magnusson Diana Swolin-Eide Altered cortical bone strength and lean mass in young women with long-duration (19 years) type 1 diabetes
description	Abstract To investigate bone health and body composition in young women with long-duration type 1 diabetes (T1D) in relation to matched controls. Twenty-three Swedish women, age 19.2–27.9 years, with a T1D duration of 10 years or more were recruited from the Swedish National Diabetes Registry (NDR). An age-, gender- and geography-matched control group was recruited. Bone mass and body composition were assessed by dual-energy X-ray absorptiometry and peripheral quantitative computed tomography. Data was retrieved from the NDR and SWEDIABKIDS registries. T1D individuals had a mean diabetes duration of 19 years. T1D individuals had reduced lean mass (40.0 ± 6.1 kg vs. 43.9 ± 4.9 kg) and were shorter (1.66 ± 0.06 m vs. 1.71 ± 0.06 m) although comparable BMI. Subjects with T1D had lower muscle area (P = 0.0045). No differences were observed for fractures; physical activity; total, lumbar spine or femur areal bone mineral density. The cortical bone strength strain index was lower for TD1 patients (1875 ± 399 mm3 vs. 2277 ± 332 mm3). In conclusion, young women with long-term diabetes duration showed reduced cortical bone strength, decreased periosteal circumference, endosteal circumference and altered body composition. These factors contribute to the health burden of TD1, which warrants further attention for advancing bone health in women with T1D.
format	article
author	Daniel Novak Gun Forsander Eva Kristiansen Anna Svedlund Per Magnusson Diana Swolin-Eide
author_facet	Daniel Novak Gun Forsander Eva Kristiansen Anna Svedlund Per Magnusson Diana Swolin-Eide
author_sort	Daniel Novak
title	Altered cortical bone strength and lean mass in young women with long-duration (19 years) type 1 diabetes
title_short	Altered cortical bone strength and lean mass in young women with long-duration (19 years) type 1 diabetes
title_full	Altered cortical bone strength and lean mass in young women with long-duration (19 years) type 1 diabetes
title_fullStr	Altered cortical bone strength and lean mass in young women with long-duration (19 years) type 1 diabetes
title_full_unstemmed	Altered cortical bone strength and lean mass in young women with long-duration (19 years) type 1 diabetes
title_sort	altered cortical bone strength and lean mass in young women with long-duration (19 years) type 1 diabetes
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/880c3cf88ad94bf59b5211388ba8c63f
work_keys_str_mv	AT danielnovak alteredcorticalbonestrengthandleanmassinyoungwomenwithlongduration19yearstype1diabetes AT gunforsander alteredcorticalbonestrengthandleanmassinyoungwomenwithlongduration19yearstype1diabetes AT evakristiansen alteredcorticalbonestrengthandleanmassinyoungwomenwithlongduration19yearstype1diabetes AT annasvedlund alteredcorticalbonestrengthandleanmassinyoungwomenwithlongduration19yearstype1diabetes AT permagnusson alteredcorticalbonestrengthandleanmassinyoungwomenwithlongduration19yearstype1diabetes AT dianaswolineide alteredcorticalbonestrengthandleanmassinyoungwomenwithlongduration19yearstype1diabetes
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Altered cortical bone strength and lean mass in young women with long-duration (19 years) type 1 diabetes

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