PRC2 and EHMT1 regulate H3K27me2 and H3K27me3 establishment across the zygote genome

PRC2 and EHMT1 regulate H3K27me2 and H3K27me3 establishment across the zygote genome

Dynamic arrangement of epigenetic modifications such as repressive H3K27 methylation is essential for zygote development. Here the authors show that establishment of genome-wide H3K27me3 in zygotes requires EZH2, that EZH1 partially compensates for EZH2 loss, and that EHMT1 is involved in H3K27me2 e...

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Autores principales: Tie-Gang Meng, Qian Zhou, Xue-Shan Ma, Xiao-Yu Liu, Qing-Ren Meng, Xian-Ju Huang, Hong-Lin Liu, Wen-Long Lei, Zheng-Hui Zhao, Ying-Chun Ouyang, Yi Hou, Heide Schatten, Xiang-Hong Ou, Zhen-Bo Wang, Shao-Rong Gao, Qing-Yuan Sun
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/880e838cf60f4e349e02ecc7127b2eb6
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Sumario:Dynamic arrangement of epigenetic modifications such as repressive H3K27 methylation is essential for zygote development. Here the authors show that establishment of genome-wide H3K27me3 in zygotes requires EZH2, that EZH1 partially compensates for EZH2 loss, and that EHMT1 is involved in H3K27me2 establishment.

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