PRC2 and EHMT1 regulate H3K27me2 and H3K27me3 establishment across the zygote genome

Dynamic arrangement of epigenetic modifications such as repressive H3K27 methylation is essential for zygote development. Here the authors show that establishment of genome-wide H3K27me3 in zygotes requires EZH2, that EZH1 partially compensates for EZH2 loss, and that EHMT1 is involved in H3K27me2 e...

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Autores principales:	Tie-Gang Meng, Qian Zhou, Xue-Shan Ma, Xiao-Yu Liu, Qing-Ren Meng, Xian-Ju Huang, Hong-Lin Liu, Wen-Long Lei, Zheng-Hui Zhao, Ying-Chun Ouyang, Yi Hou, Heide Schatten, Xiang-Hong Ou, Zhen-Bo Wang, Shao-Rong Gao, Qing-Yuan Sun
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/880e838cf60f4e349e02ecc7127b2eb6
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spelling	oai:doaj.org-article:880e838cf60f4e349e02ecc7127b2eb62021-12-02T13:23:47ZPRC2 and EHMT1 regulate H3K27me2 and H3K27me3 establishment across the zygote genome10.1038/s41467-020-20242-92041-1723https://doaj.org/article/880e838cf60f4e349e02ecc7127b2eb62020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20242-9https://doaj.org/toc/2041-1723Dynamic arrangement of epigenetic modifications such as repressive H3K27 methylation is essential for zygote development. Here the authors show that establishment of genome-wide H3K27me3 in zygotes requires EZH2, that EZH1 partially compensates for EZH2 loss, and that EHMT1 is involved in H3K27me2 establishment.Tie-Gang MengQian ZhouXue-Shan MaXiao-Yu LiuQing-Ren MengXian-Ju HuangHong-Lin LiuWen-Long LeiZheng-Hui ZhaoYing-Chun OuyangYi HouHeide SchattenXiang-Hong OuZhen-Bo WangShao-Rong GaoQing-Yuan SunNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tie-Gang Meng Qian Zhou Xue-Shan Ma Xiao-Yu Liu Qing-Ren Meng Xian-Ju Huang Hong-Lin Liu Wen-Long Lei Zheng-Hui Zhao Ying-Chun Ouyang Yi Hou Heide Schatten Xiang-Hong Ou Zhen-Bo Wang Shao-Rong Gao Qing-Yuan Sun PRC2 and EHMT1 regulate H3K27me2 and H3K27me3 establishment across the zygote genome
description	Dynamic arrangement of epigenetic modifications such as repressive H3K27 methylation is essential for zygote development. Here the authors show that establishment of genome-wide H3K27me3 in zygotes requires EZH2, that EZH1 partially compensates for EZH2 loss, and that EHMT1 is involved in H3K27me2 establishment.
format	article
author	Tie-Gang Meng Qian Zhou Xue-Shan Ma Xiao-Yu Liu Qing-Ren Meng Xian-Ju Huang Hong-Lin Liu Wen-Long Lei Zheng-Hui Zhao Ying-Chun Ouyang Yi Hou Heide Schatten Xiang-Hong Ou Zhen-Bo Wang Shao-Rong Gao Qing-Yuan Sun
author_facet	Tie-Gang Meng Qian Zhou Xue-Shan Ma Xiao-Yu Liu Qing-Ren Meng Xian-Ju Huang Hong-Lin Liu Wen-Long Lei Zheng-Hui Zhao Ying-Chun Ouyang Yi Hou Heide Schatten Xiang-Hong Ou Zhen-Bo Wang Shao-Rong Gao Qing-Yuan Sun
author_sort	Tie-Gang Meng
title	PRC2 and EHMT1 regulate H3K27me2 and H3K27me3 establishment across the zygote genome
title_short	PRC2 and EHMT1 regulate H3K27me2 and H3K27me3 establishment across the zygote genome
title_full	PRC2 and EHMT1 regulate H3K27me2 and H3K27me3 establishment across the zygote genome
title_fullStr	PRC2 and EHMT1 regulate H3K27me2 and H3K27me3 establishment across the zygote genome
title_full_unstemmed	PRC2 and EHMT1 regulate H3K27me2 and H3K27me3 establishment across the zygote genome
title_sort	prc2 and ehmt1 regulate h3k27me2 and h3k27me3 establishment across the zygote genome
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/880e838cf60f4e349e02ecc7127b2eb6
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PRC2 and EHMT1 regulate H3K27me2 and H3K27me3 establishment across the zygote genome

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