Dynamic thiol/disulphide homeostasis and ischemic modified albumin levels in isolated oligohydramnios

Objective: Oligohydramnios is defined as amniotic fluid index in ultrasonographic measurement is less than 5 percentile according to gestational age, the amniotic fluid volume is ≤ 5 cm, or if the single deepest dial is < 2 cm. The condition of oligohydramnios that not with fetal structural/chrom...

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Autores principales:	T. Kiremitli, S. Kiremitli, O. Erel, E. Oguz, K. Dinc, U. Nayki, C. Nayki, C. Turkler, A. Kirkinci
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Thiol/disulphide homeostasis Thiols IMA Oligohydroamniosis Isolated oligohydroamnios Gynecology and obstetrics RG1-991
Acceso en línea:	https://doaj.org/article/88107b5ce8144bbf9be59886e073a625
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spelling	oai:doaj.org-article:88107b5ce8144bbf9be59886e073a6252021-11-18T04:44:43ZDynamic thiol/disulphide homeostasis and ischemic modified albumin levels in isolated oligohydramnios1028-455910.1016/j.tjog.2021.09.015https://doaj.org/article/88107b5ce8144bbf9be59886e073a6252021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1028455921002552https://doaj.org/toc/1028-4559Objective: Oligohydramnios is defined as amniotic fluid index in ultrasonographic measurement is less than 5 percentile according to gestational age, the amniotic fluid volume is ≤ 5 cm, or if the single deepest dial is < 2 cm. The condition of oligohydramnios that not with fetal structural/chromosomal abnormalities, intrauterine growth retardation, intrauterine infection and maternal disease is described as isolated oligohydramnios (IO). The aim of this study is to examine whether oxidative stress and reactive oxygen species (ROS) have a place in the pathophysiology of IO. Materials and methods: In this prospective case–control study, a total of 126 participants were included. The patient group consisted of 65 patients who were diagnosed IO, and the control group consisted of 61 healthy normal pregnants. Native thiol (-SH), total thiol (-SH + -SS), dynamic disulfide (-SS), IMA values from maternal serum were measured and compared between groups. Results: Maternal serum -SH and -SH + -SS values were significantly lower in the IO group than in the control group (409.47 ± 55.36 μmol/L vs. 437.40 ± 48.68 μmol/L, p = 0.03 and 457.40 ± 63.01 μmol/L vs. 484.59 ± 52.75 μmol/L, p = 0.01). In the IO group when -SS/-SH and -SS/-SH + -SS ratio was found to be statistically significantly higher than control group (5.84 ± 1.1 vs 5.41 ± 0.71, p = 0.01 and 5.2 ± 0.88 vs 4.8 ± 0.58, p = 0.01), -SH/-SH + -SS ratio was significantly lower (89.56 ± 1.7 vs 90.24 ± 1.16, p = 0.01). There was no significant difference in terms of -SS value (p = 0.66). IMA value was significantly higher in the IO group than control group (0.76 ± 0.10 ABSU vs 0.68 ± 0.06, p < 0.01). It is seen as a result of ROC analysis that -SH, -SH + -SS, -SS/-SH, -SS/-SH + -SS, -SH/-SH + -SS and IMA values have a diagnostic value for IO (p < 0.05). Conclusion: The thiol/disulfide balance shifted towards oxidative stress in IO compared to control group. So oxidative stress and ROS have a place in the pathophysiology of IO.T. KiremitliS. KiremitliO. ErelE. OguzK. DincU. NaykiC. NaykiC. TurklerA. KirkinciElsevierarticleThiol/disulphide homeostasisThiolsIMAOligohydroamniosisIsolated oligohydroamniosGynecology and obstetricsRG1-991ENTaiwanese Journal of Obstetrics & Gynecology, Vol 60, Iss 6, Pp 1038-1042 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Thiol/disulphide homeostasis Thiols IMA Oligohydroamniosis Isolated oligohydroamnios Gynecology and obstetrics RG1-991
spellingShingle	Thiol/disulphide homeostasis Thiols IMA Oligohydroamniosis Isolated oligohydroamnios Gynecology and obstetrics RG1-991 T. Kiremitli S. Kiremitli O. Erel E. Oguz K. Dinc U. Nayki C. Nayki C. Turkler A. Kirkinci Dynamic thiol/disulphide homeostasis and ischemic modified albumin levels in isolated oligohydramnios
description	Objective: Oligohydramnios is defined as amniotic fluid index in ultrasonographic measurement is less than 5 percentile according to gestational age, the amniotic fluid volume is ≤ 5 cm, or if the single deepest dial is < 2 cm. The condition of oligohydramnios that not with fetal structural/chromosomal abnormalities, intrauterine growth retardation, intrauterine infection and maternal disease is described as isolated oligohydramnios (IO). The aim of this study is to examine whether oxidative stress and reactive oxygen species (ROS) have a place in the pathophysiology of IO. Materials and methods: In this prospective case–control study, a total of 126 participants were included. The patient group consisted of 65 patients who were diagnosed IO, and the control group consisted of 61 healthy normal pregnants. Native thiol (-SH), total thiol (-SH + -SS), dynamic disulfide (-SS), IMA values from maternal serum were measured and compared between groups. Results: Maternal serum -SH and -SH + -SS values were significantly lower in the IO group than in the control group (409.47 ± 55.36 μmol/L vs. 437.40 ± 48.68 μmol/L, p = 0.03 and 457.40 ± 63.01 μmol/L vs. 484.59 ± 52.75 μmol/L, p = 0.01). In the IO group when -SS/-SH and -SS/-SH + -SS ratio was found to be statistically significantly higher than control group (5.84 ± 1.1 vs 5.41 ± 0.71, p = 0.01 and 5.2 ± 0.88 vs 4.8 ± 0.58, p = 0.01), -SH/-SH + -SS ratio was significantly lower (89.56 ± 1.7 vs 90.24 ± 1.16, p = 0.01). There was no significant difference in terms of -SS value (p = 0.66). IMA value was significantly higher in the IO group than control group (0.76 ± 0.10 ABSU vs 0.68 ± 0.06, p < 0.01). It is seen as a result of ROC analysis that -SH, -SH + -SS, -SS/-SH, -SS/-SH + -SS, -SH/-SH + -SS and IMA values have a diagnostic value for IO (p < 0.05). Conclusion: The thiol/disulfide balance shifted towards oxidative stress in IO compared to control group. So oxidative stress and ROS have a place in the pathophysiology of IO.
format	article
author	T. Kiremitli S. Kiremitli O. Erel E. Oguz K. Dinc U. Nayki C. Nayki C. Turkler A. Kirkinci
author_facet	T. Kiremitli S. Kiremitli O. Erel E. Oguz K. Dinc U. Nayki C. Nayki C. Turkler A. Kirkinci
author_sort	T. Kiremitli
title	Dynamic thiol/disulphide homeostasis and ischemic modified albumin levels in isolated oligohydramnios
title_short	Dynamic thiol/disulphide homeostasis and ischemic modified albumin levels in isolated oligohydramnios
title_full	Dynamic thiol/disulphide homeostasis and ischemic modified albumin levels in isolated oligohydramnios
title_fullStr	Dynamic thiol/disulphide homeostasis and ischemic modified albumin levels in isolated oligohydramnios
title_full_unstemmed	Dynamic thiol/disulphide homeostasis and ischemic modified albumin levels in isolated oligohydramnios
title_sort	dynamic thiol/disulphide homeostasis and ischemic modified albumin levels in isolated oligohydramnios
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/88107b5ce8144bbf9be59886e073a625
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Dynamic thiol/disulphide homeostasis and ischemic modified albumin levels in isolated oligohydramnios

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