Adaptation and selection shape clonal evolution of tumors during residual disease and recurrence

The cellular composition of recurrent tumors can provide insight into resistance to therapy and inform on second line therapies. Here, using a genetically modified mouse, the authors perform barcoding experiments of the primary tumors to allow them to study the clonal dynamics of tumor recurrence.

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Autores principales:	Andrea Walens, Jiaxing Lin, Jeffrey S. Damrauer, Brock McKinney, Ryan Lupo, Rachel Newcomb, Douglas B. Fox, Nathaniel W. Mabe, Jeremy Gresham, Zhecheng Sheng, Alexander B. Sibley, Tristan De Buysscher, Hemant Kelkar, Piotr A. Mieczkowski, Kouros Owzar, James V. Alvarez
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/88169f662d1448619437707b70a98494
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spelling	oai:doaj.org-article:88169f662d1448619437707b70a984942021-12-02T16:57:09ZAdaptation and selection shape clonal evolution of tumors during residual disease and recurrence10.1038/s41467-020-18730-z2041-1723https://doaj.org/article/88169f662d1448619437707b70a984942020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18730-zhttps://doaj.org/toc/2041-1723The cellular composition of recurrent tumors can provide insight into resistance to therapy and inform on second line therapies. Here, using a genetically modified mouse, the authors perform barcoding experiments of the primary tumors to allow them to study the clonal dynamics of tumor recurrence.Andrea WalensJiaxing LinJeffrey S. DamrauerBrock McKinneyRyan LupoRachel NewcombDouglas B. FoxNathaniel W. MabeJeremy GreshamZhecheng ShengAlexander B. SibleyTristan De BuysscherHemant KelkarPiotr A. MieczkowskiKouros OwzarJames V. AlvarezNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Andrea Walens Jiaxing Lin Jeffrey S. Damrauer Brock McKinney Ryan Lupo Rachel Newcomb Douglas B. Fox Nathaniel W. Mabe Jeremy Gresham Zhecheng Sheng Alexander B. Sibley Tristan De Buysscher Hemant Kelkar Piotr A. Mieczkowski Kouros Owzar James V. Alvarez Adaptation and selection shape clonal evolution of tumors during residual disease and recurrence
description	The cellular composition of recurrent tumors can provide insight into resistance to therapy and inform on second line therapies. Here, using a genetically modified mouse, the authors perform barcoding experiments of the primary tumors to allow them to study the clonal dynamics of tumor recurrence.
format	article
author	Andrea Walens Jiaxing Lin Jeffrey S. Damrauer Brock McKinney Ryan Lupo Rachel Newcomb Douglas B. Fox Nathaniel W. Mabe Jeremy Gresham Zhecheng Sheng Alexander B. Sibley Tristan De Buysscher Hemant Kelkar Piotr A. Mieczkowski Kouros Owzar James V. Alvarez
author_facet	Andrea Walens Jiaxing Lin Jeffrey S. Damrauer Brock McKinney Ryan Lupo Rachel Newcomb Douglas B. Fox Nathaniel W. Mabe Jeremy Gresham Zhecheng Sheng Alexander B. Sibley Tristan De Buysscher Hemant Kelkar Piotr A. Mieczkowski Kouros Owzar James V. Alvarez
author_sort	Andrea Walens
title	Adaptation and selection shape clonal evolution of tumors during residual disease and recurrence
title_short	Adaptation and selection shape clonal evolution of tumors during residual disease and recurrence
title_full	Adaptation and selection shape clonal evolution of tumors during residual disease and recurrence
title_fullStr	Adaptation and selection shape clonal evolution of tumors during residual disease and recurrence
title_full_unstemmed	Adaptation and selection shape clonal evolution of tumors during residual disease and recurrence
title_sort	adaptation and selection shape clonal evolution of tumors during residual disease and recurrence
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/88169f662d1448619437707b70a98494
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Adaptation and selection shape clonal evolution of tumors during residual disease and recurrence

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