Adaptation and selection shape clonal evolution of tumors during residual disease and recurrence

Adaptation and selection shape clonal evolution of tumors during residual disease and recurrence

The cellular composition of recurrent tumors can provide insight into resistance to therapy and inform on second line therapies. Here, using a genetically modified mouse, the authors perform barcoding experiments of the primary tumors to allow them to study the clonal dynamics of tumor recurrence.

Saved in:
Bibliographic Details
Main Authors: Andrea Walens, Jiaxing Lin, Jeffrey S. Damrauer, Brock McKinney, Ryan Lupo, Rachel Newcomb, Douglas B. Fox, Nathaniel W. Mabe, Jeremy Gresham, Zhecheng Sheng, Alexander B. Sibley, Tristan De Buysscher, Hemant Kelkar, Piotr A. Mieczkowski, Kouros Owzar, James V. Alvarez
Format: article
Language:EN
Published: Nature Portfolio 2020
Subjects:
Science
Q
Online Access:https://doaj.org/article/88169f662d1448619437707b70a98494
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doaj.org/article/88169f662d1448619437707b70a98494

Similar Items