FREQUENCY OF PATHOLOGICAL COMPLETE RESPONSE (PCR) IN PATIENTS OF TRIPLE NEGATIVE BREAST CANCER AFTER NEO-ADJUVANT CHEMOTHERAPY

Objective: To determine the frequency of patients with complete pathological response (pCR) after neo adjuvant chemotherapy (NACT) in locally advanced triple negative breast cancer. Study Design: Descriptive cross sectional study. Place and Duration of Study: Department of Oncology, Hameed Lat...

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Autores principales:	Zeeshan Ahmed Khan Niazi, Amjad Zafar, Muhammad Wasim Sattar, Waleeja Shamikha, Zaigam Ismail, Muhammad Abbas Khokhar
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2021
Materias:	breast cancer neo-adjuvant therapy pathological response Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/88170cb9572a42fcb301ae16c233f109
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spelling	oai:doaj.org-article:88170cb9572a42fcb301ae16c233f1092021-12-02T18:01:40ZFREQUENCY OF PATHOLOGICAL COMPLETE RESPONSE (PCR) IN PATIENTS OF TRIPLE NEGATIVE BREAST CANCER AFTER NEO-ADJUVANT CHEMOTHERAPY0030-96482411-8842https://doaj.org/article/88170cb9572a42fcb301ae16c233f1092021-04-01T00:00:00Zhttps://pafmj.org/index.php/PAFMJ/article/view/6658https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To determine the frequency of patients with complete pathological response (pCR) after neo adjuvant chemotherapy (NACT) in locally advanced triple negative breast cancer. Study Design: Descriptive cross sectional study. Place and Duration of Study: Department of Oncology, Hameed Latif Hospital, Lahore, from Aug 2019 to Feb 2020. Methodology: After taking approval from hospital ethics committee, 100 patients coming through Out-patient department who fulfill the selection criteria were enrolled and written informed consent were taken from them. Results: A total of 100 fulfilling the inclusion/exclusion criteria were enrolled to study to determine frequency of patients with complete pathological response after neo adjuvant chemotherapy in locally advanced triple negative breast cancer. Age distribution of the patients was done, it shows that out of 100 patients, 38 (38%) were between 18-40 years of age whereas 62 (62%) in were between 41-70 years of age, mean age was calculated as 44.18 ± 9.71 years. The data was stratified for age, stage of disease and eastern cooperative oncology group (ECOG) grade of the patients. When associated with grades of the disease, it was found to be statistically significant (p=0.003). Conclusion: Hence we concluded that about one third of the patients with neo adjuvant chemotherapy showed complete pathological response.Zeeshan Ahmed Khan NiaziAmjad ZafarMuhammad Wasim SattarWaleeja ShamikhaZaigam IsmailMuhammad Abbas KhokharArmy Medical College Rawalpindiarticlebreast cancerneo-adjuvant therapypathological responseMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 71, Iss 2, Pp 460-63 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	breast cancer neo-adjuvant therapy pathological response Medicine R Medicine (General) R5-920
spellingShingle	breast cancer neo-adjuvant therapy pathological response Medicine R Medicine (General) R5-920 Zeeshan Ahmed Khan Niazi Amjad Zafar Muhammad Wasim Sattar Waleeja Shamikha Zaigam Ismail Muhammad Abbas Khokhar FREQUENCY OF PATHOLOGICAL COMPLETE RESPONSE (PCR) IN PATIENTS OF TRIPLE NEGATIVE BREAST CANCER AFTER NEO-ADJUVANT CHEMOTHERAPY
description	Objective: To determine the frequency of patients with complete pathological response (pCR) after neo adjuvant chemotherapy (NACT) in locally advanced triple negative breast cancer. Study Design: Descriptive cross sectional study. Place and Duration of Study: Department of Oncology, Hameed Latif Hospital, Lahore, from Aug 2019 to Feb 2020. Methodology: After taking approval from hospital ethics committee, 100 patients coming through Out-patient department who fulfill the selection criteria were enrolled and written informed consent were taken from them. Results: A total of 100 fulfilling the inclusion/exclusion criteria were enrolled to study to determine frequency of patients with complete pathological response after neo adjuvant chemotherapy in locally advanced triple negative breast cancer. Age distribution of the patients was done, it shows that out of 100 patients, 38 (38%) were between 18-40 years of age whereas 62 (62%) in were between 41-70 years of age, mean age was calculated as 44.18 ± 9.71 years. The data was stratified for age, stage of disease and eastern cooperative oncology group (ECOG) grade of the patients. When associated with grades of the disease, it was found to be statistically significant (p=0.003). Conclusion: Hence we concluded that about one third of the patients with neo adjuvant chemotherapy showed complete pathological response.
format	article
author	Zeeshan Ahmed Khan Niazi Amjad Zafar Muhammad Wasim Sattar Waleeja Shamikha Zaigam Ismail Muhammad Abbas Khokhar
author_facet	Zeeshan Ahmed Khan Niazi Amjad Zafar Muhammad Wasim Sattar Waleeja Shamikha Zaigam Ismail Muhammad Abbas Khokhar
author_sort	Zeeshan Ahmed Khan Niazi
title	FREQUENCY OF PATHOLOGICAL COMPLETE RESPONSE (PCR) IN PATIENTS OF TRIPLE NEGATIVE BREAST CANCER AFTER NEO-ADJUVANT CHEMOTHERAPY
title_short	FREQUENCY OF PATHOLOGICAL COMPLETE RESPONSE (PCR) IN PATIENTS OF TRIPLE NEGATIVE BREAST CANCER AFTER NEO-ADJUVANT CHEMOTHERAPY
title_full	FREQUENCY OF PATHOLOGICAL COMPLETE RESPONSE (PCR) IN PATIENTS OF TRIPLE NEGATIVE BREAST CANCER AFTER NEO-ADJUVANT CHEMOTHERAPY
title_fullStr	FREQUENCY OF PATHOLOGICAL COMPLETE RESPONSE (PCR) IN PATIENTS OF TRIPLE NEGATIVE BREAST CANCER AFTER NEO-ADJUVANT CHEMOTHERAPY
title_full_unstemmed	FREQUENCY OF PATHOLOGICAL COMPLETE RESPONSE (PCR) IN PATIENTS OF TRIPLE NEGATIVE BREAST CANCER AFTER NEO-ADJUVANT CHEMOTHERAPY
title_sort	frequency of pathological complete response (pcr) in patients of triple negative breast cancer after neo-adjuvant chemotherapy
publisher	Army Medical College Rawalpindi
publishDate	2021
url	https://doaj.org/article/88170cb9572a42fcb301ae16c233f109
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FREQUENCY OF PATHOLOGICAL COMPLETE RESPONSE (PCR) IN PATIENTS OF TRIPLE NEGATIVE BREAST CANCER AFTER NEO-ADJUVANT CHEMOTHERAPY

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