Truncation and constitutive activation of the androgen receptor by diverse genomic rearrangements in prostate cancer

Castration-resistant prostate cancer frequently presents with persistent androgen receptor signalling. Here, the authors find that the androgen receptor is subject to genetic rearrangements, resulting in variants with ligand-independent activity.

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Autores principales:	Christine Henzler, Yingming Li, Rendong Yang, Terri McBride, Yeung Ho, Cynthia Sprenger, Gang Liu, Ilsa Coleman, Bryce Lakely, Rui Li, Shihong Ma, Sean R. Landman, Vipin Kumar, Tae Hyun Hwang, Ganesh V. Raj, Celestia S. Higano, Colm Morrissey, Peter S. Nelson, Stephen R. Plymate, Scott M. Dehm
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/881742f5c87d4d33a058d2ab18e6588c
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spelling	oai:doaj.org-article:881742f5c87d4d33a058d2ab18e6588c2021-12-02T17:33:20ZTruncation and constitutive activation of the androgen receptor by diverse genomic rearrangements in prostate cancer10.1038/ncomms136682041-1723https://doaj.org/article/881742f5c87d4d33a058d2ab18e6588c2016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13668https://doaj.org/toc/2041-1723Castration-resistant prostate cancer frequently presents with persistent androgen receptor signalling. Here, the authors find that the androgen receptor is subject to genetic rearrangements, resulting in variants with ligand-independent activity.Christine HenzlerYingming LiRendong YangTerri McBrideYeung HoCynthia SprengerGang LiuIlsa ColemanBryce LakelyRui LiShihong MaSean R. LandmanVipin KumarTae Hyun HwangGanesh V. RajCelestia S. HiganoColm MorrisseyPeter S. NelsonStephen R. PlymateScott M. DehmNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Christine Henzler Yingming Li Rendong Yang Terri McBride Yeung Ho Cynthia Sprenger Gang Liu Ilsa Coleman Bryce Lakely Rui Li Shihong Ma Sean R. Landman Vipin Kumar Tae Hyun Hwang Ganesh V. Raj Celestia S. Higano Colm Morrissey Peter S. Nelson Stephen R. Plymate Scott M. Dehm Truncation and constitutive activation of the androgen receptor by diverse genomic rearrangements in prostate cancer
description	Castration-resistant prostate cancer frequently presents with persistent androgen receptor signalling. Here, the authors find that the androgen receptor is subject to genetic rearrangements, resulting in variants with ligand-independent activity.
format	article
author	Christine Henzler Yingming Li Rendong Yang Terri McBride Yeung Ho Cynthia Sprenger Gang Liu Ilsa Coleman Bryce Lakely Rui Li Shihong Ma Sean R. Landman Vipin Kumar Tae Hyun Hwang Ganesh V. Raj Celestia S. Higano Colm Morrissey Peter S. Nelson Stephen R. Plymate Scott M. Dehm
author_facet	Christine Henzler Yingming Li Rendong Yang Terri McBride Yeung Ho Cynthia Sprenger Gang Liu Ilsa Coleman Bryce Lakely Rui Li Shihong Ma Sean R. Landman Vipin Kumar Tae Hyun Hwang Ganesh V. Raj Celestia S. Higano Colm Morrissey Peter S. Nelson Stephen R. Plymate Scott M. Dehm
author_sort	Christine Henzler
title	Truncation and constitutive activation of the androgen receptor by diverse genomic rearrangements in prostate cancer
title_short	Truncation and constitutive activation of the androgen receptor by diverse genomic rearrangements in prostate cancer
title_full	Truncation and constitutive activation of the androgen receptor by diverse genomic rearrangements in prostate cancer
title_fullStr	Truncation and constitutive activation of the androgen receptor by diverse genomic rearrangements in prostate cancer
title_full_unstemmed	Truncation and constitutive activation of the androgen receptor by diverse genomic rearrangements in prostate cancer
title_sort	truncation and constitutive activation of the androgen receptor by diverse genomic rearrangements in prostate cancer
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/881742f5c87d4d33a058d2ab18e6588c
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Truncation and constitutive activation of the androgen receptor by diverse genomic rearrangements in prostate cancer

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