Synthesis, Characterization and Biological Efficacies from Some New Dinuclear Metal Complexes for Base 3-(3,4-Dihydroxy-phenyl)-2-[(2-hydroxy-3-methylperoxy-benzylidene)-amino]-2-methyl Propionic Acid

The reaction of methyldopa with o-vanillin in refluxing ethanol afforded Schiff base and characterized through physical analysis with a number of spectra also the study of biological activity. The geometry of the Schiff base was identified through using (C.H.N) analysis, Mass, 1H-NMR, FT-IR, UV-Vis...

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Autores principales:	Shatha Mohammed Hassan Obaid, Jasim Shihab Sultan, Abbas Ali Salih Al-Hamdani
Formato:	article
Lenguaje:	EN
Publicado:	Department of Chemistry, Universitas Gadjah Mada 2020
Materias:	methyldopa o-vanillin schiff base complexes spectral studies biological efficacy Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/88195ce8892a48819e476321e759dbf9
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spelling	oai:doaj.org-article:88195ce8892a48819e476321e759dbf92021-12-02T16:11:23ZSynthesis, Characterization and Biological Efficacies from Some New Dinuclear Metal Complexes for Base 3-(3,4-Dihydroxy-phenyl)-2-[(2-hydroxy-3-methylperoxy-benzylidene)-amino]-2-methyl Propionic Acid1411-94202460-157810.22146/ijc.49842https://doaj.org/article/88195ce8892a48819e476321e759dbf92020-09-01T00:00:00Zhttps://jurnal.ugm.ac.id/ijc/article/view/49842https://doaj.org/toc/1411-9420https://doaj.org/toc/2460-1578The reaction of methyldopa with o-vanillin in refluxing ethanol afforded Schiff base and characterized through physical analysis with a number of spectra also the study of biological activity. The geometry of the Schiff base was identified through using (C.H.N) analysis, Mass, 1H-NMR, FT-IR, UV-Vis spectroscopy. Metal complexes of Cr3+, Mn2+, Co2+, Ni2+, Cu2+, Zn2+, Cd2+ and Hg2+ with Schiff base have been prepared in the molar ratio 2:1 (Metal:L), (L = Schiff base ligand) except Hg2+ at molar ratio 1:1 (Hg:L). The prepared complexes were characterized by using Mass, FT-IR and UV-Vis spectral studies, on other than magnetic properties and flame atomic absorption, conductivity measurements. According to the results a dinuclear octahedral geometry has been suggested for Cr3+, Mn2+, Co2+, Ni2+, Cu2+ and Zn2+ complexes, dinuclear tetrahedral for Cd2+ and mononuclear tetrahedral for Hg2+ complex. This work highlights the relevance of metal complexation strategy to stabilize the ligands and improve their bioactivity. Schiff base complexes have been screen for their antibacterial activity against Gram negative and positive bacteria and antifungal activity showing promising antibacterial and biological activity.Shatha Mohammed Hassan ObaidJasim Shihab SultanAbbas Ali Salih Al-HamdaniDepartment of Chemistry, Universitas Gadjah Madaarticlemethyldopao-vanillinschiff base complexesspectral studiesbiological efficacyChemistryQD1-999ENIndonesian Journal of Chemistry, Vol 20, Iss 6, Pp 1311-1322 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	methyldopa o-vanillin schiff base complexes spectral studies biological efficacy Chemistry QD1-999
spellingShingle	methyldopa o-vanillin schiff base complexes spectral studies biological efficacy Chemistry QD1-999 Shatha Mohammed Hassan Obaid Jasim Shihab Sultan Abbas Ali Salih Al-Hamdani Synthesis, Characterization and Biological Efficacies from Some New Dinuclear Metal Complexes for Base 3-(3,4-Dihydroxy-phenyl)-2-[(2-hydroxy-3-methylperoxy-benzylidene)-amino]-2-methyl Propionic Acid
description	The reaction of methyldopa with o-vanillin in refluxing ethanol afforded Schiff base and characterized through physical analysis with a number of spectra also the study of biological activity. The geometry of the Schiff base was identified through using (C.H.N) analysis, Mass, 1H-NMR, FT-IR, UV-Vis spectroscopy. Metal complexes of Cr3+, Mn2+, Co2+, Ni2+, Cu2+, Zn2+, Cd2+ and Hg2+ with Schiff base have been prepared in the molar ratio 2:1 (Metal:L), (L = Schiff base ligand) except Hg2+ at molar ratio 1:1 (Hg:L). The prepared complexes were characterized by using Mass, FT-IR and UV-Vis spectral studies, on other than magnetic properties and flame atomic absorption, conductivity measurements. According to the results a dinuclear octahedral geometry has been suggested for Cr3+, Mn2+, Co2+, Ni2+, Cu2+ and Zn2+ complexes, dinuclear tetrahedral for Cd2+ and mononuclear tetrahedral for Hg2+ complex. This work highlights the relevance of metal complexation strategy to stabilize the ligands and improve their bioactivity. Schiff base complexes have been screen for their antibacterial activity against Gram negative and positive bacteria and antifungal activity showing promising antibacterial and biological activity.
format	article
author	Shatha Mohammed Hassan Obaid Jasim Shihab Sultan Abbas Ali Salih Al-Hamdani
author_facet	Shatha Mohammed Hassan Obaid Jasim Shihab Sultan Abbas Ali Salih Al-Hamdani
author_sort	Shatha Mohammed Hassan Obaid
title	Synthesis, Characterization and Biological Efficacies from Some New Dinuclear Metal Complexes for Base 3-(3,4-Dihydroxy-phenyl)-2-[(2-hydroxy-3-methylperoxy-benzylidene)-amino]-2-methyl Propionic Acid
title_short	Synthesis, Characterization and Biological Efficacies from Some New Dinuclear Metal Complexes for Base 3-(3,4-Dihydroxy-phenyl)-2-[(2-hydroxy-3-methylperoxy-benzylidene)-amino]-2-methyl Propionic Acid
title_full	Synthesis, Characterization and Biological Efficacies from Some New Dinuclear Metal Complexes for Base 3-(3,4-Dihydroxy-phenyl)-2-[(2-hydroxy-3-methylperoxy-benzylidene)-amino]-2-methyl Propionic Acid
title_fullStr	Synthesis, Characterization and Biological Efficacies from Some New Dinuclear Metal Complexes for Base 3-(3,4-Dihydroxy-phenyl)-2-[(2-hydroxy-3-methylperoxy-benzylidene)-amino]-2-methyl Propionic Acid
title_full_unstemmed	Synthesis, Characterization and Biological Efficacies from Some New Dinuclear Metal Complexes for Base 3-(3,4-Dihydroxy-phenyl)-2-[(2-hydroxy-3-methylperoxy-benzylidene)-amino]-2-methyl Propionic Acid
title_sort	synthesis, characterization and biological efficacies from some new dinuclear metal complexes for base 3-(3,4-dihydroxy-phenyl)-2-[(2-hydroxy-3-methylperoxy-benzylidene)-amino]-2-methyl propionic acid
publisher	Department of Chemistry, Universitas Gadjah Mada
publishDate	2020
url	https://doaj.org/article/88195ce8892a48819e476321e759dbf9
work_keys_str_mv	AT shathamohammedhassanobaid synthesischaracterizationandbiologicalefficaciesfromsomenewdinuclearmetalcomplexesforbase334dihydroxyphenyl22hydroxy3methylperoxybenzylideneamino2methylpropionicacid AT jasimshihabsultan synthesischaracterizationandbiologicalefficaciesfromsomenewdinuclearmetalcomplexesforbase334dihydroxyphenyl22hydroxy3methylperoxybenzylideneamino2methylpropionicacid AT abbasalisalihalhamdani synthesischaracterizationandbiologicalefficaciesfromsomenewdinuclearmetalcomplexesforbase334dihydroxyphenyl22hydroxy3methylperoxybenzylideneamino2methylpropionicacid
_version_	1718384421213569024

Synthesis, Characterization and Biological Efficacies from Some New Dinuclear Metal Complexes for Base 3-(3,4-Dihydroxy-phenyl)-2-[(2-hydroxy-3-methylperoxy-benzylidene)-amino]-2-methyl Propionic Acid

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