Differential gene expression regulated by oscillatory transcription factors.

Cells respond to changes in the internal and external environment by a complex regulatory system whose end-point is the activation of transcription factors controlling the expression of a pool of ad-hoc genes. Recent experiments have shown that certain stimuli may trigger oscillations in the concent...

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Autores principales:	Luca Cerone, Zoltán Neufeld
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/881efc3babb6447796b6aae21b57c04c
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spelling	oai:doaj.org-article:881efc3babb6447796b6aae21b57c04c2021-11-18T07:29:30ZDifferential gene expression regulated by oscillatory transcription factors.1932-620310.1371/journal.pone.0030283https://doaj.org/article/881efc3babb6447796b6aae21b57c04c2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22291930/?tool=EBIhttps://doaj.org/toc/1932-6203Cells respond to changes in the internal and external environment by a complex regulatory system whose end-point is the activation of transcription factors controlling the expression of a pool of ad-hoc genes. Recent experiments have shown that certain stimuli may trigger oscillations in the concentration of transcription factors such as NF-κB and p53 influencing the final outcome of the genetic response. In this study we investigate the role of oscillations in the case of three different well known gene regulatory mechanisms using mathematical models based on ordinary differential equations and numerical simulations. We considered the cases of direct regulation, two-step regulation and feed-forward loops, and characterized their response to oscillatory input signals both analytically and numerically. We show that in the case of indirect two-step regulation the expression of genes can be turned on or off in a frequency dependent manner, and that feed-forward loops are also able to selectively respond to the temporal profile of oscillating transcription factors.Luca CeroneZoltán NeufeldPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 1, p e30283 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Luca Cerone Zoltán Neufeld Differential gene expression regulated by oscillatory transcription factors.
description	Cells respond to changes in the internal and external environment by a complex regulatory system whose end-point is the activation of transcription factors controlling the expression of a pool of ad-hoc genes. Recent experiments have shown that certain stimuli may trigger oscillations in the concentration of transcription factors such as NF-κB and p53 influencing the final outcome of the genetic response. In this study we investigate the role of oscillations in the case of three different well known gene regulatory mechanisms using mathematical models based on ordinary differential equations and numerical simulations. We considered the cases of direct regulation, two-step regulation and feed-forward loops, and characterized their response to oscillatory input signals both analytically and numerically. We show that in the case of indirect two-step regulation the expression of genes can be turned on or off in a frequency dependent manner, and that feed-forward loops are also able to selectively respond to the temporal profile of oscillating transcription factors.
format	article
author	Luca Cerone Zoltán Neufeld
author_facet	Luca Cerone Zoltán Neufeld
author_sort	Luca Cerone
title	Differential gene expression regulated by oscillatory transcription factors.
title_short	Differential gene expression regulated by oscillatory transcription factors.
title_full	Differential gene expression regulated by oscillatory transcription factors.
title_fullStr	Differential gene expression regulated by oscillatory transcription factors.
title_full_unstemmed	Differential gene expression regulated by oscillatory transcription factors.
title_sort	differential gene expression regulated by oscillatory transcription factors.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/881efc3babb6447796b6aae21b57c04c
work_keys_str_mv	AT lucacerone differentialgeneexpressionregulatedbyoscillatorytranscriptionfactors AT zoltanneufeld differentialgeneexpressionregulatedbyoscillatorytranscriptionfactors
_version_	1718423357200793600

Differential gene expression regulated by oscillatory transcription factors.

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