Serum lipid profile in HCV patients treated with direct-acting antivirals: a systematic review and meta-analysis

Abstract Although direct-acting antivirals are very effective and safe drugs, several authors have reported the alteration of lipid profile during and after anti-HCV therapy suggesting a potential impact on the risk of cardiovascular events. We performed a systematic review and meta-analysis of obse...

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Autores principales:	Rosanna Villani, Francesca Di Cosimo, Antonino Davide Romano, Moris Sangineto, Gaetano Serviddio
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/882100244dc04735ad11b9611996c8ba
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spelling	oai:doaj.org-article:882100244dc04735ad11b9611996c8ba2021-12-02T15:39:50ZSerum lipid profile in HCV patients treated with direct-acting antivirals: a systematic review and meta-analysis10.1038/s41598-021-93251-32045-2322https://doaj.org/article/882100244dc04735ad11b9611996c8ba2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93251-3https://doaj.org/toc/2045-2322Abstract Although direct-acting antivirals are very effective and safe drugs, several authors have reported the alteration of lipid profile during and after anti-HCV therapy suggesting a potential impact on the risk of cardiovascular events. We performed a systematic review and meta-analysis of observational studies to investigate the magnitude and temporal trend of lipid profile changes in DAA treated patients. All selected studies included data on lipid profile before starting therapy and at least one follow-up assessment during or after antiviral treatment. We identified 14 studies (N = 1537 patients) after removing duplicates. Pooled data showed an increase in total cholesterol 4 weeks after starting therapy (+ 15.86 mg/dl; 95% CI + 9.68 to 22.05; p < 0.001) and 12 weeks after treatment completion (+ 17.05 mg/dl; 95% CI + 11.24 to 22.85; p < 0.001). LDL trend was similar to the total cholesterol change in overall analysis. A mean increase in HDL-cholesterol of 3.36 mg/dl (95% CI + 0.92 to 5.79; p = 0.07) was observed after 12 weeks of treatment, whereas at SVR24 HDL difference was + 4.34 mg/dl (95% CI + 1.40 to 7.28; p = 0.004).Triglycerides did not show significant changes during treatment and after treatment completion. DAAs induce mild lipid changes in chronic hepatitis C patients treated with DAAs, which may persist after treatment completion.Rosanna VillaniFrancesca Di CosimoAntonino Davide RomanoMoris SanginetoGaetano ServiddioNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rosanna Villani Francesca Di Cosimo Antonino Davide Romano Moris Sangineto Gaetano Serviddio Serum lipid profile in HCV patients treated with direct-acting antivirals: a systematic review and meta-analysis
description	Abstract Although direct-acting antivirals are very effective and safe drugs, several authors have reported the alteration of lipid profile during and after anti-HCV therapy suggesting a potential impact on the risk of cardiovascular events. We performed a systematic review and meta-analysis of observational studies to investigate the magnitude and temporal trend of lipid profile changes in DAA treated patients. All selected studies included data on lipid profile before starting therapy and at least one follow-up assessment during or after antiviral treatment. We identified 14 studies (N = 1537 patients) after removing duplicates. Pooled data showed an increase in total cholesterol 4 weeks after starting therapy (+ 15.86 mg/dl; 95% CI + 9.68 to 22.05; p < 0.001) and 12 weeks after treatment completion (+ 17.05 mg/dl; 95% CI + 11.24 to 22.85; p < 0.001). LDL trend was similar to the total cholesterol change in overall analysis. A mean increase in HDL-cholesterol of 3.36 mg/dl (95% CI + 0.92 to 5.79; p = 0.07) was observed after 12 weeks of treatment, whereas at SVR24 HDL difference was + 4.34 mg/dl (95% CI + 1.40 to 7.28; p = 0.004).Triglycerides did not show significant changes during treatment and after treatment completion. DAAs induce mild lipid changes in chronic hepatitis C patients treated with DAAs, which may persist after treatment completion.
format	article
author	Rosanna Villani Francesca Di Cosimo Antonino Davide Romano Moris Sangineto Gaetano Serviddio
author_facet	Rosanna Villani Francesca Di Cosimo Antonino Davide Romano Moris Sangineto Gaetano Serviddio
author_sort	Rosanna Villani
title	Serum lipid profile in HCV patients treated with direct-acting antivirals: a systematic review and meta-analysis
title_short	Serum lipid profile in HCV patients treated with direct-acting antivirals: a systematic review and meta-analysis
title_full	Serum lipid profile in HCV patients treated with direct-acting antivirals: a systematic review and meta-analysis
title_fullStr	Serum lipid profile in HCV patients treated with direct-acting antivirals: a systematic review and meta-analysis
title_full_unstemmed	Serum lipid profile in HCV patients treated with direct-acting antivirals: a systematic review and meta-analysis
title_sort	serum lipid profile in hcv patients treated with direct-acting antivirals: a systematic review and meta-analysis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/882100244dc04735ad11b9611996c8ba
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Serum lipid profile in HCV patients treated with direct-acting antivirals: a systematic review and meta-analysis

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