A nano-sandwich construct built with graphene nanosheets and carbon nanotubes enhances mechanical properties of hydroxyapatite–polyetheretherketone scaffolds
Pei Feng,1,* Shuping Peng,2,3,* Ping Wu,4 Chengde Gao,1 Wei Huang,1 Youwen Deng,5 Tao Xiao,5 Cijun Shuai1 1State Key Laboratory of High Performance Complex Manufacturing, 2The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, 3The Key Laboratory of Carcinoge...
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Dove Medical Press
2016
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oai:doaj.org-article:8823277eae714f58b04d98132a0081a12021-12-02T07:12:10ZA nano-sandwich construct built with graphene nanosheets and carbon nanotubes enhances mechanical properties of hydroxyapatite–polyetheretherketone scaffolds1178-2013https://doaj.org/article/8823277eae714f58b04d98132a0081a12016-07-01T00:00:00Zhttps://www.dovepress.com/a-nano-sandwich-construct-built-with-graphene-nanosheets-and-carbon-na-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Pei Feng,1,* Shuping Peng,2,3,* Ping Wu,4 Chengde Gao,1 Wei Huang,1 Youwen Deng,5 Tao Xiao,5 Cijun Shuai1 1State Key Laboratory of High Performance Complex Manufacturing, 2The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, 3The Key Laboratory of Carcinogenesis of the Chinese Ministry of Health and Cancer Research Institute, Xiangya Hospital, Central South University, Changsha, 4College of Chemistry, Xiangtan University, Xiangtan, 5Department of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha, People’s Republic of China *These authors contributed equally to this work Abstract: A nano-sandwich construct was built by combining two-dimensional graphene nanosheets (GNSs) and one-dimensional carbon nanotubes (CNTs) to improve the mechanical properties of hydroxyapatite–polyetheretherketone (HAP–PEEK) scaffolds for bone tissue engineering. In this nano-sandwich construct, the long tubular CNTs penetrated the interlayers of graphene and prevented their aggregation, increasing the effective contact area between the construct and matrix. The combination of GNSs and CNTs in a weight ratio of 2:8 facilitated the dispersion of each other and provided a synergetic effect in enhancing the mechanical properties. The compressive strength and modulus of the scaffolds were increased by 63.58% and 56.54% at this time compared with those of HAP–PEEK scaffolds, respectively. The carbon-based fillers, pulling out and bridging, were also clearly observed in the matrix. Moreover, the dangling of CNTs and their entangling with GNSs further reinforced the mechanical properties. Furthermore, apatite layer formed on the scaffold surface after immersing in simulated body fluid, and the cells attached and spread well on the surface of the scaffolds and displayed good viability, proliferation, and differentiation. These evidence indicate that the HAP–PEEK scaffolds enhanced by GNSs and CNTs are a promising alternative for bone tissue engineering. Keywords: scaffold, mechanical properties, apatite-forming ability, cell culture, tissue engineering Feng PPeng SWu PGao CHuang WDeng YXiao TShuai CDove Medical Pressarticlegraphene nanosheetscarbon nanotubesnano sandwich constructpolyetheretherketonehydroxyapatiteMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2016, Iss default, Pp 3487-3500 (2016) |
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graphene nanosheets carbon nanotubes nano sandwich construct polyetheretherketone hydroxyapatite Medicine (General) R5-920 |
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graphene nanosheets carbon nanotubes nano sandwich construct polyetheretherketone hydroxyapatite Medicine (General) R5-920 Feng P Peng S Wu P Gao C Huang W Deng Y Xiao T Shuai C A nano-sandwich construct built with graphene nanosheets and carbon nanotubes enhances mechanical properties of hydroxyapatite–polyetheretherketone scaffolds |
| description |
Pei Feng,1,* Shuping Peng,2,3,* Ping Wu,4 Chengde Gao,1 Wei Huang,1 Youwen Deng,5 Tao Xiao,5 Cijun Shuai1 1State Key Laboratory of High Performance Complex Manufacturing, 2The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, 3The Key Laboratory of Carcinogenesis of the Chinese Ministry of Health and Cancer Research Institute, Xiangya Hospital, Central South University, Changsha, 4College of Chemistry, Xiangtan University, Xiangtan, 5Department of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha, People’s Republic of China *These authors contributed equally to this work Abstract: A nano-sandwich construct was built by combining two-dimensional graphene nanosheets (GNSs) and one-dimensional carbon nanotubes (CNTs) to improve the mechanical properties of hydroxyapatite–polyetheretherketone (HAP–PEEK) scaffolds for bone tissue engineering. In this nano-sandwich construct, the long tubular CNTs penetrated the interlayers of graphene and prevented their aggregation, increasing the effective contact area between the construct and matrix. The combination of GNSs and CNTs in a weight ratio of 2:8 facilitated the dispersion of each other and provided a synergetic effect in enhancing the mechanical properties. The compressive strength and modulus of the scaffolds were increased by 63.58% and 56.54% at this time compared with those of HAP–PEEK scaffolds, respectively. The carbon-based fillers, pulling out and bridging, were also clearly observed in the matrix. Moreover, the dangling of CNTs and their entangling with GNSs further reinforced the mechanical properties. Furthermore, apatite layer formed on the scaffold surface after immersing in simulated body fluid, and the cells attached and spread well on the surface of the scaffolds and displayed good viability, proliferation, and differentiation. These evidence indicate that the HAP–PEEK scaffolds enhanced by GNSs and CNTs are a promising alternative for bone tissue engineering. Keywords: scaffold, mechanical properties, apatite-forming ability, cell culture, tissue engineering |
| format |
article |
| author |
Feng P Peng S Wu P Gao C Huang W Deng Y Xiao T Shuai C |
| author_facet |
Feng P Peng S Wu P Gao C Huang W Deng Y Xiao T Shuai C |
| author_sort |
Feng P |
| title |
A nano-sandwich construct built with graphene nanosheets and carbon nanotubes enhances mechanical properties of hydroxyapatite–polyetheretherketone scaffolds |
| title_short |
A nano-sandwich construct built with graphene nanosheets and carbon nanotubes enhances mechanical properties of hydroxyapatite–polyetheretherketone scaffolds |
| title_full |
A nano-sandwich construct built with graphene nanosheets and carbon nanotubes enhances mechanical properties of hydroxyapatite–polyetheretherketone scaffolds |
| title_fullStr |
A nano-sandwich construct built with graphene nanosheets and carbon nanotubes enhances mechanical properties of hydroxyapatite–polyetheretherketone scaffolds |
| title_full_unstemmed |
A nano-sandwich construct built with graphene nanosheets and carbon nanotubes enhances mechanical properties of hydroxyapatite–polyetheretherketone scaffolds |
| title_sort |
nano-sandwich construct built with graphene nanosheets and carbon nanotubes enhances mechanical properties of hydroxyapatite–polyetheretherketone scaffolds |
| publisher |
Dove Medical Press |
| publishDate |
2016 |
| url |
https://doaj.org/article/8823277eae714f58b04d98132a0081a1 |
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