The role of osteocytes in targeted bone remodeling: a mathematical model.

Until recently many studies of bone remodeling at the cellular level have focused on the behavior of mature osteoblasts and osteoclasts, and their respective precursor cells, with the role of osteocytes and bone lining cells left largely unexplored. This is particularly true with respect to the math...

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Autores principales:	Jason M Graham, Bruce P Ayati, Sarah A Holstein, James A Martin
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/88238894a5b5480e9c23570734601f0b
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spelling	oai:doaj.org-article:88238894a5b5480e9c23570734601f0b2021-11-18T07:44:39ZThe role of osteocytes in targeted bone remodeling: a mathematical model.1932-620310.1371/journal.pone.0063884https://doaj.org/article/88238894a5b5480e9c23570734601f0b2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23717504/?tool=EBIhttps://doaj.org/toc/1932-6203Until recently many studies of bone remodeling at the cellular level have focused on the behavior of mature osteoblasts and osteoclasts, and their respective precursor cells, with the role of osteocytes and bone lining cells left largely unexplored. This is particularly true with respect to the mathematical modeling of bone remodeling. However, there is increasing evidence that osteocytes play important roles in the cycle of targeted bone remodeling, in serving as a significant source of RANKL to support osteoclastogenesis, and in secreting the bone formation inhibitor sclerostin. Moreover, there is also increasing interest in sclerostin, an osteocyte-secreted bone formation inhibitor, and its role in regulating local response to changes in the bone microenvironment. Here we develop a cell population model of bone remodeling that includes the role of osteocytes, sclerostin, and allows for the possibility of RANKL expression by osteocyte cell populations. We have aimed to give a simple, yet still tractable, model that remains faithful to the underlying system based on the known literature. This model extends and complements many of the existing mathematical models for bone remodeling, but can be used to explore aspects of the process of bone remodeling that were previously beyond the scope of prior modeling work. Through numerical simulations we demonstrate that our model can be used to explore theoretically many of the qualitative features of the role of osteocytes in bone biology as presented in recent literature.Jason M GrahamBruce P AyatiSarah A HolsteinJames A MartinPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 5, p e63884 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jason M Graham Bruce P Ayati Sarah A Holstein James A Martin The role of osteocytes in targeted bone remodeling: a mathematical model.
description	Until recently many studies of bone remodeling at the cellular level have focused on the behavior of mature osteoblasts and osteoclasts, and their respective precursor cells, with the role of osteocytes and bone lining cells left largely unexplored. This is particularly true with respect to the mathematical modeling of bone remodeling. However, there is increasing evidence that osteocytes play important roles in the cycle of targeted bone remodeling, in serving as a significant source of RANKL to support osteoclastogenesis, and in secreting the bone formation inhibitor sclerostin. Moreover, there is also increasing interest in sclerostin, an osteocyte-secreted bone formation inhibitor, and its role in regulating local response to changes in the bone microenvironment. Here we develop a cell population model of bone remodeling that includes the role of osteocytes, sclerostin, and allows for the possibility of RANKL expression by osteocyte cell populations. We have aimed to give a simple, yet still tractable, model that remains faithful to the underlying system based on the known literature. This model extends and complements many of the existing mathematical models for bone remodeling, but can be used to explore aspects of the process of bone remodeling that were previously beyond the scope of prior modeling work. Through numerical simulations we demonstrate that our model can be used to explore theoretically many of the qualitative features of the role of osteocytes in bone biology as presented in recent literature.
format	article
author	Jason M Graham Bruce P Ayati Sarah A Holstein James A Martin
author_facet	Jason M Graham Bruce P Ayati Sarah A Holstein James A Martin
author_sort	Jason M Graham
title	The role of osteocytes in targeted bone remodeling: a mathematical model.
title_short	The role of osteocytes in targeted bone remodeling: a mathematical model.
title_full	The role of osteocytes in targeted bone remodeling: a mathematical model.
title_fullStr	The role of osteocytes in targeted bone remodeling: a mathematical model.
title_full_unstemmed	The role of osteocytes in targeted bone remodeling: a mathematical model.
title_sort	role of osteocytes in targeted bone remodeling: a mathematical model.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/88238894a5b5480e9c23570734601f0b
work_keys_str_mv	AT jasonmgraham theroleofosteocytesintargetedboneremodelingamathematicalmodel AT brucepayati theroleofosteocytesintargetedboneremodelingamathematicalmodel AT sarahaholstein theroleofosteocytesintargetedboneremodelingamathematicalmodel AT jamesamartin theroleofosteocytesintargetedboneremodelingamathematicalmodel AT jasonmgraham roleofosteocytesintargetedboneremodelingamathematicalmodel AT brucepayati roleofosteocytesintargetedboneremodelingamathematicalmodel AT sarahaholstein roleofosteocytesintargetedboneremodelingamathematicalmodel AT jamesamartin roleofosteocytesintargetedboneremodelingamathematicalmodel
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The role of osteocytes in targeted bone remodeling: a mathematical model.

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