Silver nanoparticles modify VEGF signaling pathway and mucus hypersecretion in allergic airway inflammation

Sunhyae Jang1,*, Ji Won Park2,*, Hye Rim Cha1, Sun Young Jung1, Jeong Eun Lee1, Sung Soo Jung1, Ju Ock Kim1, Sun Young Kim1, Choong Sik Lee3, Hee Sun Park1 1Division of Pulmonology, Allergy and Critical Care Medicine, Department of Internal Medicine, Chungnam National University Medical School, Daej...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jang S, Park JW, Cha HR, Jung SY, Lee JE, Jung SS, Kim JO, Kim SY, Lee CS, Park HS
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/882506faafa043a1af0872cd704e5c98
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:882506faafa043a1af0872cd704e5c98
record_format	dspace
spelling	oai:doaj.org-article:882506faafa043a1af0872cd704e5c982021-12-02T01:07:52ZSilver nanoparticles modify VEGF signaling pathway and mucus hypersecretion in allergic airway inflammation1176-91141178-2013https://doaj.org/article/882506faafa043a1af0872cd704e5c982012-03-01T00:00:00Zhttp://www.dovepress.com/silver-nanoparticles-modify-vegf-signaling-pathway-and-mucus-hypersecr-a9484https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Sunhyae Jang1,, Ji Won Park2,, Hye Rim Cha1, Sun Young Jung1, Jeong Eun Lee1, Sung Soo Jung1, Ju Ock Kim1, Sun Young Kim1, Choong Sik Lee3, Hee Sun Park1 1Division of Pulmonology, Allergy and Critical Care Medicine, Department of Internal Medicine, Chungnam National University Medical School, Daejeon, 2Division of Pulmonology, Department of Internal Medicine, Daejeon St Mary&#39;s Hospital, College of Medicine, The Catholic University of Korea, Daejeon, 3Department of Pathology, Chungnam National University Medical School, Daejeon, South Korea*These authors contributed equally to this workAbstract: The anti-inflammatory action of silver nanoparticles (NPs) has been reported in a murine model of asthma in a previous study. But more specific mechanisms of silver NPs in an attenuation of allergic airway inflammation have not yet been established. Vascular and mucous changes are believed to contribute largely in pathophysiology in asthma. Among various factors related to vascular changes, vascular endothelial growth factor (VEGF) plays a pivotal role in vascular changes in asthma. Mucin proteins MUC5AC and MUC5B have been implicated as markers of goblet cell metaplasia in lung pathologies. The aim of this study was to investigate the effects of silver NPs on VEGF signaling pathways and mucus hypersecretion. Ovalbumin (OVA)-inhaled female BALBc mice were used to evaluate the role of silver NPs and the related molecular mechanisms in allergic airway disease. In this study, with an OVA-induced murine model of allergic airway disease, it was found that the increased levels of hypoxia-inducible factor (HIF)-1&alpha;, VEGF, phosphatidylinositol-3 kinase (PI3K) and phosphorylated-Akt levels, and mucous glycoprotein expression (Muc5ac) in lung tissues were substantially decreased by the administration of silver NPs. In summary, silver NPs substantially suppressed mucus hypersecretion and PI3K/HIF-1&alpha;/VEGF signaling pathway in an allergic airway inflammation.Keywords: allergic airway disease, hypoxia inducible factor-1&alpha;, vascular endothelial growth factorJang SPark JWCha HRJung SYLee JEJung SSKim JOKim SYLee CSPark HSDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2012, Iss default, Pp 1329-1343 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Jang S Park JW Cha HR Jung SY Lee JE Jung SS Kim JO Kim SY Lee CS Park HS Silver nanoparticles modify VEGF signaling pathway and mucus hypersecretion in allergic airway inflammation
description	Sunhyae Jang1,, Ji Won Park2,, Hye Rim Cha1, Sun Young Jung1, Jeong Eun Lee1, Sung Soo Jung1, Ju Ock Kim1, Sun Young Kim1, Choong Sik Lee3, Hee Sun Park1 1Division of Pulmonology, Allergy and Critical Care Medicine, Department of Internal Medicine, Chungnam National University Medical School, Daejeon, 2Division of Pulmonology, Department of Internal Medicine, Daejeon St Mary&#39;s Hospital, College of Medicine, The Catholic University of Korea, Daejeon, 3Department of Pathology, Chungnam National University Medical School, Daejeon, South Korea*These authors contributed equally to this workAbstract: The anti-inflammatory action of silver nanoparticles (NPs) has been reported in a murine model of asthma in a previous study. But more specific mechanisms of silver NPs in an attenuation of allergic airway inflammation have not yet been established. Vascular and mucous changes are believed to contribute largely in pathophysiology in asthma. Among various factors related to vascular changes, vascular endothelial growth factor (VEGF) plays a pivotal role in vascular changes in asthma. Mucin proteins MUC5AC and MUC5B have been implicated as markers of goblet cell metaplasia in lung pathologies. The aim of this study was to investigate the effects of silver NPs on VEGF signaling pathways and mucus hypersecretion. Ovalbumin (OVA)-inhaled female BALBc mice were used to evaluate the role of silver NPs and the related molecular mechanisms in allergic airway disease. In this study, with an OVA-induced murine model of allergic airway disease, it was found that the increased levels of hypoxia-inducible factor (HIF)-1&alpha;, VEGF, phosphatidylinositol-3 kinase (PI3K) and phosphorylated-Akt levels, and mucous glycoprotein expression (Muc5ac) in lung tissues were substantially decreased by the administration of silver NPs. In summary, silver NPs substantially suppressed mucus hypersecretion and PI3K/HIF-1&alpha;/VEGF signaling pathway in an allergic airway inflammation.Keywords: allergic airway disease, hypoxia inducible factor-1&alpha;, vascular endothelial growth factor
format	article
author	Jang S Park JW Cha HR Jung SY Lee JE Jung SS Kim JO Kim SY Lee CS Park HS
author_facet	Jang S Park JW Cha HR Jung SY Lee JE Jung SS Kim JO Kim SY Lee CS Park HS
author_sort	Jang S
title	Silver nanoparticles modify VEGF signaling pathway and mucus hypersecretion in allergic airway inflammation
title_short	Silver nanoparticles modify VEGF signaling pathway and mucus hypersecretion in allergic airway inflammation
title_full	Silver nanoparticles modify VEGF signaling pathway and mucus hypersecretion in allergic airway inflammation
title_fullStr	Silver nanoparticles modify VEGF signaling pathway and mucus hypersecretion in allergic airway inflammation
title_full_unstemmed	Silver nanoparticles modify VEGF signaling pathway and mucus hypersecretion in allergic airway inflammation
title_sort	silver nanoparticles modify vegf signaling pathway and mucus hypersecretion in allergic airway inflammation
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/882506faafa043a1af0872cd704e5c98
work_keys_str_mv	AT jangs silvernanoparticlesmodifyvegfsignalingpathwayandmucushypersecretioninallergicairwayinflammation AT parkjw silvernanoparticlesmodifyvegfsignalingpathwayandmucushypersecretioninallergicairwayinflammation AT chahr silvernanoparticlesmodifyvegfsignalingpathwayandmucushypersecretioninallergicairwayinflammation AT jungsy silvernanoparticlesmodifyvegfsignalingpathwayandmucushypersecretioninallergicairwayinflammation AT leeje silvernanoparticlesmodifyvegfsignalingpathwayandmucushypersecretioninallergicairwayinflammation AT jungss silvernanoparticlesmodifyvegfsignalingpathwayandmucushypersecretioninallergicairwayinflammation AT kimjo silvernanoparticlesmodifyvegfsignalingpathwayandmucushypersecretioninallergicairwayinflammation AT kimsy silvernanoparticlesmodifyvegfsignalingpathwayandmucushypersecretioninallergicairwayinflammation AT leecs silvernanoparticlesmodifyvegfsignalingpathwayandmucushypersecretioninallergicairwayinflammation AT parkhs silvernanoparticlesmodifyvegfsignalingpathwayandmucushypersecretioninallergicairwayinflammation
_version_	1718403269629313024

Silver nanoparticles modify VEGF signaling pathway and mucus hypersecretion in allergic airway inflammation

Ejemplares similares