Stabilization of p21 by mTORC1/4E-BP1 predicts clinical outcome of head and neck cancers

The molecular pathways involving p21 and mTORC1 are frequently deregulated in head and neck squamous cell carcinomas (HNSCC). Here, Llanos et al. report a mechanism that regulates p21 stability through the mTORC1/4E-BP1 pathway independently of p53, and show that the mechanism is prevalent in HNSCC.

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Auteurs principaux:	Susana Llanos, Juana M. García-Pedrero, Lucia Morgado-Palacin, Juan P. Rodrigo, Manuel Serrano
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2016
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/88255eacb3924844babdce1250c9e72f
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id	oai:doaj.org-article:88255eacb3924844babdce1250c9e72f
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spelling	oai:doaj.org-article:88255eacb3924844babdce1250c9e72f2021-12-02T15:34:53ZStabilization of p21 by mTORC1/4E-BP1 predicts clinical outcome of head and neck cancers10.1038/ncomms104382041-1723https://doaj.org/article/88255eacb3924844babdce1250c9e72f2016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10438https://doaj.org/toc/2041-1723The molecular pathways involving p21 and mTORC1 are frequently deregulated in head and neck squamous cell carcinomas (HNSCC). Here, Llanos et al. report a mechanism that regulates p21 stability through the mTORC1/4E-BP1 pathway independently of p53, and show that the mechanism is prevalent in HNSCC.Susana LlanosJuana M. García-PedreroLucia Morgado-PalacinJuan P. RodrigoManuel SerranoNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Susana Llanos Juana M. García-Pedrero Lucia Morgado-Palacin Juan P. Rodrigo Manuel Serrano Stabilization of p21 by mTORC1/4E-BP1 predicts clinical outcome of head and neck cancers
description	The molecular pathways involving p21 and mTORC1 are frequently deregulated in head and neck squamous cell carcinomas (HNSCC). Here, Llanos et al. report a mechanism that regulates p21 stability through the mTORC1/4E-BP1 pathway independently of p53, and show that the mechanism is prevalent in HNSCC.
format	article
author	Susana Llanos Juana M. García-Pedrero Lucia Morgado-Palacin Juan P. Rodrigo Manuel Serrano
author_facet	Susana Llanos Juana M. García-Pedrero Lucia Morgado-Palacin Juan P. Rodrigo Manuel Serrano
author_sort	Susana Llanos
title	Stabilization of p21 by mTORC1/4E-BP1 predicts clinical outcome of head and neck cancers
title_short	Stabilization of p21 by mTORC1/4E-BP1 predicts clinical outcome of head and neck cancers
title_full	Stabilization of p21 by mTORC1/4E-BP1 predicts clinical outcome of head and neck cancers
title_fullStr	Stabilization of p21 by mTORC1/4E-BP1 predicts clinical outcome of head and neck cancers
title_full_unstemmed	Stabilization of p21 by mTORC1/4E-BP1 predicts clinical outcome of head and neck cancers
title_sort	stabilization of p21 by mtorc1/4e-bp1 predicts clinical outcome of head and neck cancers
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/88255eacb3924844babdce1250c9e72f
work_keys_str_mv	AT susanallanos stabilizationofp21bymtorc14ebp1predictsclinicaloutcomeofheadandneckcancers AT juanamgarciapedrero stabilizationofp21bymtorc14ebp1predictsclinicaloutcomeofheadandneckcancers AT luciamorgadopalacin stabilizationofp21bymtorc14ebp1predictsclinicaloutcomeofheadandneckcancers AT juanprodrigo stabilizationofp21bymtorc14ebp1predictsclinicaloutcomeofheadandneckcancers AT manuelserrano stabilizationofp21bymtorc14ebp1predictsclinicaloutcomeofheadandneckcancers
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Stabilization of p21 by mTORC1/4E-BP1 predicts clinical outcome of head and neck cancers

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