Free Radical Scavenging Capacities and Alleviating Actions of Polysaccharides Extract of Termitomyces le-testui on Methylprednisolone-Induced Immunodepression in Rats

Background. Natural products have been said to show immunomodulatory and antioxidant activities. The research study was aimed to assess the immunomodulatory and free radical scavenging activities of crude polysaccharide from dry mushroom fruiting bodies of Termitomyces le-testui. Materials and Metho...

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Autores principales:	Foncham Evans Ngwenah, Kada Sanda Antoine, Salah Martin, Tume Christopher, Oumar Mahamat
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/8826bc6a2e1d468cb33ed44f5b9f067f
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spelling	oai:doaj.org-article:8826bc6a2e1d468cb33ed44f5b9f067f2021-11-22T01:09:34ZFree Radical Scavenging Capacities and Alleviating Actions of Polysaccharides Extract of Termitomyces le-testui on Methylprednisolone-Induced Immunodepression in Rats2633-469010.1155/2021/5893210https://doaj.org/article/8826bc6a2e1d468cb33ed44f5b9f067f2021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/5893210https://doaj.org/toc/2633-4690Background. Natural products have been said to show immunomodulatory and antioxidant activities. The research study was aimed to assess the immunomodulatory and free radical scavenging activities of crude polysaccharide from dry mushroom fruiting bodies of Termitomyces le-testui. Materials and Methods. Hot water extract of polysaccharide extract of T. le-testui was prepared and tested in white albino Wister rats for its immunomodulatory activities effect on methylprednisolone-immunosuppressed animals. In addition, the radical scavenging activity of the polysaccharide was evaluated using nitrite and hydrogen peroxide. Results. The result of the study showed that the polysaccharide T. le-testui increases the phagocytic index, energy metabolism of macrophages, spleen index, and nitric oxide in a concentration-dependent manner in immunosuppressed animals. Also, it was observed that the extract increased dose-dependent total oxidative stress and thymus index. Finally, the crude polysaccharide-rich extract showed nitrite and hydrogen peroxide scavenging activity in a concentration-dependent manner. Conclusion. Polysaccharide-rich extract possesses immunomodulatory and antioxidant properties.Foncham Evans NgwenahKada Sanda AntoineSalah MartinTume ChristopherOumar MahamatHindawi LimitedarticleTherapeutics. PharmacologyRM1-950ENAdvances in Pharmacological and Pharmaceutical Sciences, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Therapeutics. Pharmacology RM1-950
spellingShingle	Therapeutics. Pharmacology RM1-950 Foncham Evans Ngwenah Kada Sanda Antoine Salah Martin Tume Christopher Oumar Mahamat Free Radical Scavenging Capacities and Alleviating Actions of Polysaccharides Extract of Termitomyces le-testui on Methylprednisolone-Induced Immunodepression in Rats
description	Background. Natural products have been said to show immunomodulatory and antioxidant activities. The research study was aimed to assess the immunomodulatory and free radical scavenging activities of crude polysaccharide from dry mushroom fruiting bodies of Termitomyces le-testui. Materials and Methods. Hot water extract of polysaccharide extract of T. le-testui was prepared and tested in white albino Wister rats for its immunomodulatory activities effect on methylprednisolone-immunosuppressed animals. In addition, the radical scavenging activity of the polysaccharide was evaluated using nitrite and hydrogen peroxide. Results. The result of the study showed that the polysaccharide T. le-testui increases the phagocytic index, energy metabolism of macrophages, spleen index, and nitric oxide in a concentration-dependent manner in immunosuppressed animals. Also, it was observed that the extract increased dose-dependent total oxidative stress and thymus index. Finally, the crude polysaccharide-rich extract showed nitrite and hydrogen peroxide scavenging activity in a concentration-dependent manner. Conclusion. Polysaccharide-rich extract possesses immunomodulatory and antioxidant properties.
format	article
author	Foncham Evans Ngwenah Kada Sanda Antoine Salah Martin Tume Christopher Oumar Mahamat
author_facet	Foncham Evans Ngwenah Kada Sanda Antoine Salah Martin Tume Christopher Oumar Mahamat
author_sort	Foncham Evans Ngwenah
title	Free Radical Scavenging Capacities and Alleviating Actions of Polysaccharides Extract of Termitomyces le-testui on Methylprednisolone-Induced Immunodepression in Rats
title_short	Free Radical Scavenging Capacities and Alleviating Actions of Polysaccharides Extract of Termitomyces le-testui on Methylprednisolone-Induced Immunodepression in Rats
title_full	Free Radical Scavenging Capacities and Alleviating Actions of Polysaccharides Extract of Termitomyces le-testui on Methylprednisolone-Induced Immunodepression in Rats
title_fullStr	Free Radical Scavenging Capacities and Alleviating Actions of Polysaccharides Extract of Termitomyces le-testui on Methylprednisolone-Induced Immunodepression in Rats
title_full_unstemmed	Free Radical Scavenging Capacities and Alleviating Actions of Polysaccharides Extract of Termitomyces le-testui on Methylprednisolone-Induced Immunodepression in Rats
title_sort	free radical scavenging capacities and alleviating actions of polysaccharides extract of termitomyces le-testui on methylprednisolone-induced immunodepression in rats
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/8826bc6a2e1d468cb33ed44f5b9f067f
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Free Radical Scavenging Capacities and Alleviating Actions of Polysaccharides Extract of Termitomyces le-testui on Methylprednisolone-Induced Immunodepression in Rats

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