Impact of genetic variants on major bleeding after percutaneous coronary intervention based on a prospective multicenter registry

Abstract Although dual antiplatelet therapy is essential for patients who undergo percutaneous coronary interventions, the risk of bleeding remains an unsolved problem, and there is limited information on the potential relationship between genetic variants and major bleeding. We analyzed the correla...

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Autores principales:	Jung-Joon Cha, Hyung Joon Joo, Jae Hyoung Park, Soon Jun Hong, Tae Hoon Ahn, Byeong-Keuk Kim, WonYong Shin, Sung Gyun Ahn, JungHan Yoon, Yong Hoon Kim, Yun-Hyeong Cho, Woong Chol Kang, Weon Kim, Young-Hyo Lim, HyeonCheol Gwon, WoongGil Choi, Do-Sun Lim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/88296c60657b4af3991aeb6b41a5f227
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spelling	oai:doaj.org-article:88296c60657b4af3991aeb6b41a5f2272021-12-02T15:23:47ZImpact of genetic variants on major bleeding after percutaneous coronary intervention based on a prospective multicenter registry10.1038/s41598-020-80319-92045-2322https://doaj.org/article/88296c60657b4af3991aeb6b41a5f2272021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80319-9https://doaj.org/toc/2045-2322Abstract Although dual antiplatelet therapy is essential for patients who undergo percutaneous coronary interventions, the risk of bleeding remains an unsolved problem, and there is limited information on the potential relationship between genetic variants and major bleeding. We analyzed the correlations between four major single nucleotide polymorphisms (CYP2C19, ABCB1, PON1, and P2Y12 G52T polymorphisms) and clinical outcomes in 4489 patients from a prospective multicenter registry. The primary endpoint was major bleeding, defined as a Bleeding Academic Research Consortium ≥ 3 bleeding event. The allelic frequencies of ABCB1, PON1, and both individual and combined CYP2C19 variants did not differ significantly between patient groups with and without major bleeding. However, the allelic frequency of the P2Y12 variant differed significantly between the two groups. Focusing on the P2Y12 G52T variant, patients in the TT group had a significantly higher rate of major bleeding (6.4%; adjusted hazard ratio [HR] 2.51; 95% confidence interval [CI] 1.08–5.84; p = 0.033) than patients in the other groups (GG [2.9%] or GT [1.9%]). Therefore, the TT variant of the P2Y12 G52T polymorphism may be an independent predictor of major bleeding. Trial registration: NCT02707445 ( https://clinicaltrials.gov/ct2/show/NCT02707445?term=02707445&draw=2&rank=1 ).Jung-Joon ChaHyung Joon JooJae Hyoung ParkSoon Jun HongTae Hoon AhnByeong-Keuk KimWonYong ShinSung Gyun AhnJungHan YoonYong Hoon KimYun-Hyeong ChoWoong Chol KangWeon KimYoung-Hyo LimHyeonCheol GwonWoongGil ChoiDo-Sun LimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jung-Joon Cha Hyung Joon Joo Jae Hyoung Park Soon Jun Hong Tae Hoon Ahn Byeong-Keuk Kim WonYong Shin Sung Gyun Ahn JungHan Yoon Yong Hoon Kim Yun-Hyeong Cho Woong Chol Kang Weon Kim Young-Hyo Lim HyeonCheol Gwon WoongGil Choi Do-Sun Lim Impact of genetic variants on major bleeding after percutaneous coronary intervention based on a prospective multicenter registry
description	Abstract Although dual antiplatelet therapy is essential for patients who undergo percutaneous coronary interventions, the risk of bleeding remains an unsolved problem, and there is limited information on the potential relationship between genetic variants and major bleeding. We analyzed the correlations between four major single nucleotide polymorphisms (CYP2C19, ABCB1, PON1, and P2Y12 G52T polymorphisms) and clinical outcomes in 4489 patients from a prospective multicenter registry. The primary endpoint was major bleeding, defined as a Bleeding Academic Research Consortium ≥ 3 bleeding event. The allelic frequencies of ABCB1, PON1, and both individual and combined CYP2C19 variants did not differ significantly between patient groups with and without major bleeding. However, the allelic frequency of the P2Y12 variant differed significantly between the two groups. Focusing on the P2Y12 G52T variant, patients in the TT group had a significantly higher rate of major bleeding (6.4%; adjusted hazard ratio [HR] 2.51; 95% confidence interval [CI] 1.08–5.84; p = 0.033) than patients in the other groups (GG [2.9%] or GT [1.9%]). Therefore, the TT variant of the P2Y12 G52T polymorphism may be an independent predictor of major bleeding. Trial registration: NCT02707445 ( https://clinicaltrials.gov/ct2/show/NCT02707445?term=02707445&draw=2&rank=1 ).
format	article
author	Jung-Joon Cha Hyung Joon Joo Jae Hyoung Park Soon Jun Hong Tae Hoon Ahn Byeong-Keuk Kim WonYong Shin Sung Gyun Ahn JungHan Yoon Yong Hoon Kim Yun-Hyeong Cho Woong Chol Kang Weon Kim Young-Hyo Lim HyeonCheol Gwon WoongGil Choi Do-Sun Lim
author_facet	Jung-Joon Cha Hyung Joon Joo Jae Hyoung Park Soon Jun Hong Tae Hoon Ahn Byeong-Keuk Kim WonYong Shin Sung Gyun Ahn JungHan Yoon Yong Hoon Kim Yun-Hyeong Cho Woong Chol Kang Weon Kim Young-Hyo Lim HyeonCheol Gwon WoongGil Choi Do-Sun Lim
author_sort	Jung-Joon Cha
title	Impact of genetic variants on major bleeding after percutaneous coronary intervention based on a prospective multicenter registry
title_short	Impact of genetic variants on major bleeding after percutaneous coronary intervention based on a prospective multicenter registry
title_full	Impact of genetic variants on major bleeding after percutaneous coronary intervention based on a prospective multicenter registry
title_fullStr	Impact of genetic variants on major bleeding after percutaneous coronary intervention based on a prospective multicenter registry
title_full_unstemmed	Impact of genetic variants on major bleeding after percutaneous coronary intervention based on a prospective multicenter registry
title_sort	impact of genetic variants on major bleeding after percutaneous coronary intervention based on a prospective multicenter registry
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/88296c60657b4af3991aeb6b41a5f227
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Impact of genetic variants on major bleeding after percutaneous coronary intervention based on a prospective multicenter registry

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