From regenerative dentistry to regenerative medicine: progress, challenges, and potential applications of oral stem cells

Li Xiao,1 Masanori Nasu2 1Department of Pharmacology, 2Research Center, The Nippon Dental University, Tokyo, Japan Abstract: Adult mesenchymal stem cells (MSCs) and epithelial stem cells play essential roles in tissue repair and self-healing. Oral MSCs and epithelial stem cells can be isolated from...

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Autores principales: Xiao L, Nasu M
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Publicado: Dove Medical Press 2014
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spelling oai:doaj.org-article:882d2c0ab65f40479f23ed31ea2fdabe2021-12-02T06:39:20ZFrom regenerative dentistry to regenerative medicine: progress, challenges, and potential applications of oral stem cells1178-6957https://doaj.org/article/882d2c0ab65f40479f23ed31ea2fdabe2014-12-01T00:00:00Zhttp://www.dovepress.com/from-regenerative-dentistry-to-regenerative-medicine-progress-challeng-peer-reviewed-article-SCCAAhttps://doaj.org/toc/1178-6957 Li Xiao,1 Masanori Nasu2 1Department of Pharmacology, 2Research Center, The Nippon Dental University, Tokyo, Japan Abstract: Adult mesenchymal stem cells (MSCs) and epithelial stem cells play essential roles in tissue repair and self-healing. Oral MSCs and epithelial stem cells can be isolated from adult human oral tissues, for example, teeth, periodontal ligament, and gingiva. Cocultivated adult oral epithelial stem cells and MSCs could represent some developmental events, such as epithelial invagination and tubular structure formation, signifying their potentials for tissue regeneration. Oral epithelial stem cells have been used in regenerative medicine over 1 decade. They are able to form a stratified cell sheet under three-dimensional culture conditions. Both experimental and clinical data indicate that the cell sheets can not only safely and effectively reconstruct the damaged cornea in humans, but also repair esophageal ulcer in animal models. Oral MSCs include dental pulp stem cells (DPSCs), stem cells from exfoliated deciduous teeth (SHED), stem cells from apical papilla (SCAP), periodontal ligament stem cells (PDLSCs), and mesenchymal stem cells from gingiva (GMSCs). They are widely applied in both regenerative dentistry and medicine. DPSCs, SHED, and SCAP are able to form dentin–pulp complex when being transplanted into immunodeficient animals. They have been experimentally used for the regeneration of dental pulp, neuron, bone muscle and blood vessels in animal models and have shown promising results. PDLSCs and GMSCs are demonstrated to be ideal cell sources for repairing the damaged tissues of periodontal, muscle, and tendon. Despite the abovementioned applications of oral stem cells, only a few human clinical trials are now underway to use them for the treatment of certain diseases. Since clinical use is the end goal, their true regenerative power and safety need to be further examined.Keywords: oral mesenchymal stem cells, oral epithelial stem cells, cell transplantation, regenerationXiao LNasu MDove Medical PressarticleCytologyQH573-671ENStem Cells and Cloning: Advances and Applications, Vol 2014, Iss default, Pp 89-99 (2014)
institution DOAJ
collection DOAJ
language EN
topic Cytology
QH573-671
spellingShingle Cytology
QH573-671
Xiao L
Nasu M
From regenerative dentistry to regenerative medicine: progress, challenges, and potential applications of oral stem cells
description Li Xiao,1 Masanori Nasu2 1Department of Pharmacology, 2Research Center, The Nippon Dental University, Tokyo, Japan Abstract: Adult mesenchymal stem cells (MSCs) and epithelial stem cells play essential roles in tissue repair and self-healing. Oral MSCs and epithelial stem cells can be isolated from adult human oral tissues, for example, teeth, periodontal ligament, and gingiva. Cocultivated adult oral epithelial stem cells and MSCs could represent some developmental events, such as epithelial invagination and tubular structure formation, signifying their potentials for tissue regeneration. Oral epithelial stem cells have been used in regenerative medicine over 1 decade. They are able to form a stratified cell sheet under three-dimensional culture conditions. Both experimental and clinical data indicate that the cell sheets can not only safely and effectively reconstruct the damaged cornea in humans, but also repair esophageal ulcer in animal models. Oral MSCs include dental pulp stem cells (DPSCs), stem cells from exfoliated deciduous teeth (SHED), stem cells from apical papilla (SCAP), periodontal ligament stem cells (PDLSCs), and mesenchymal stem cells from gingiva (GMSCs). They are widely applied in both regenerative dentistry and medicine. DPSCs, SHED, and SCAP are able to form dentin–pulp complex when being transplanted into immunodeficient animals. They have been experimentally used for the regeneration of dental pulp, neuron, bone muscle and blood vessels in animal models and have shown promising results. PDLSCs and GMSCs are demonstrated to be ideal cell sources for repairing the damaged tissues of periodontal, muscle, and tendon. Despite the abovementioned applications of oral stem cells, only a few human clinical trials are now underway to use them for the treatment of certain diseases. Since clinical use is the end goal, their true regenerative power and safety need to be further examined.Keywords: oral mesenchymal stem cells, oral epithelial stem cells, cell transplantation, regeneration
format article
author Xiao L
Nasu M
author_facet Xiao L
Nasu M
author_sort Xiao L
title From regenerative dentistry to regenerative medicine: progress, challenges, and potential applications of oral stem cells
title_short From regenerative dentistry to regenerative medicine: progress, challenges, and potential applications of oral stem cells
title_full From regenerative dentistry to regenerative medicine: progress, challenges, and potential applications of oral stem cells
title_fullStr From regenerative dentistry to regenerative medicine: progress, challenges, and potential applications of oral stem cells
title_full_unstemmed From regenerative dentistry to regenerative medicine: progress, challenges, and potential applications of oral stem cells
title_sort from regenerative dentistry to regenerative medicine: progress, challenges, and potential applications of oral stem cells
publisher Dove Medical Press
publishDate 2014
url https://doaj.org/article/882d2c0ab65f40479f23ed31ea2fdabe
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AT nasum fromregenerativedentistrytoregenerativemedicineprogresschallengesandpotentialapplicationsoforalstemcells
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