From regenerative dentistry to regenerative medicine: progress, challenges, and potential applications of oral stem cells

Li Xiao,1 Masanori Nasu2 1Department of Pharmacology, 2Research Center, The Nippon Dental University, Tokyo, Japan Abstract: Adult mesenchymal stem cells (MSCs) and epithelial stem cells play essential roles in tissue repair and self-healing. Oral MSCs and epithelial stem cells can be isolated from...

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Autores principales:	Xiao L, Nasu M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Cytology QH573-671
Acceso en línea:	https://doaj.org/article/882d2c0ab65f40479f23ed31ea2fdabe
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spelling	oai:doaj.org-article:882d2c0ab65f40479f23ed31ea2fdabe2021-12-02T06:39:20ZFrom regenerative dentistry to regenerative medicine: progress, challenges, and potential applications of oral stem cells1178-6957https://doaj.org/article/882d2c0ab65f40479f23ed31ea2fdabe2014-12-01T00:00:00Zhttp://www.dovepress.com/from-regenerative-dentistry-to-regenerative-medicine-progress-challeng-peer-reviewed-article-SCCAAhttps://doaj.org/toc/1178-6957 Li Xiao,1 Masanori Nasu2 1Department of Pharmacology, 2Research Center, The Nippon Dental University, Tokyo, Japan Abstract: Adult mesenchymal stem cells (MSCs) and epithelial stem cells play essential roles in tissue repair and self-healing. Oral MSCs and epithelial stem cells can be isolated from adult human oral tissues, for example, teeth, periodontal ligament, and gingiva. Cocultivated adult oral epithelial stem cells and MSCs could represent some developmental events, such as epithelial invagination and tubular structure formation, signifying their potentials for tissue regeneration. Oral epithelial stem cells have been used in regenerative medicine over 1 decade. They are able to form a stratified cell sheet under three-dimensional culture conditions. Both experimental and clinical data indicate that the cell sheets can not only safely and effectively reconstruct the damaged cornea in humans, but also repair esophageal ulcer in animal models. Oral MSCs include dental pulp stem cells (DPSCs), stem cells from exfoliated deciduous teeth (SHED), stem cells from apical papilla (SCAP), periodontal ligament stem cells (PDLSCs), and mesenchymal stem cells from gingiva (GMSCs). They are widely applied in both regenerative dentistry and medicine. DPSCs, SHED, and SCAP are able to form dentin–pulp complex when being transplanted into immunodeficient animals. They have been experimentally used for the regeneration of dental pulp, neuron, bone muscle and blood vessels in animal models and have shown promising results. PDLSCs and GMSCs are demonstrated to be ideal cell sources for repairing the damaged tissues of periodontal, muscle, and tendon. Despite the abovementioned applications of oral stem cells, only a few human clinical trials are now underway to use them for the treatment of certain diseases. Since clinical use is the end goal, their true regenerative power and safety need to be further examined.Keywords: oral mesenchymal stem cells, oral epithelial stem cells, cell transplantation, regenerationXiao LNasu MDove Medical PressarticleCytologyQH573-671ENStem Cells and Cloning: Advances and Applications, Vol 2014, Iss default, Pp 89-99 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cytology QH573-671
spellingShingle	Cytology QH573-671 Xiao L Nasu M From regenerative dentistry to regenerative medicine: progress, challenges, and potential applications of oral stem cells
description	Li Xiao,1 Masanori Nasu2 1Department of Pharmacology, 2Research Center, The Nippon Dental University, Tokyo, Japan Abstract: Adult mesenchymal stem cells (MSCs) and epithelial stem cells play essential roles in tissue repair and self-healing. Oral MSCs and epithelial stem cells can be isolated from adult human oral tissues, for example, teeth, periodontal ligament, and gingiva. Cocultivated adult oral epithelial stem cells and MSCs could represent some developmental events, such as epithelial invagination and tubular structure formation, signifying their potentials for tissue regeneration. Oral epithelial stem cells have been used in regenerative medicine over 1 decade. They are able to form a stratified cell sheet under three-dimensional culture conditions. Both experimental and clinical data indicate that the cell sheets can not only safely and effectively reconstruct the damaged cornea in humans, but also repair esophageal ulcer in animal models. Oral MSCs include dental pulp stem cells (DPSCs), stem cells from exfoliated deciduous teeth (SHED), stem cells from apical papilla (SCAP), periodontal ligament stem cells (PDLSCs), and mesenchymal stem cells from gingiva (GMSCs). They are widely applied in both regenerative dentistry and medicine. DPSCs, SHED, and SCAP are able to form dentin–pulp complex when being transplanted into immunodeficient animals. They have been experimentally used for the regeneration of dental pulp, neuron, bone muscle and blood vessels in animal models and have shown promising results. PDLSCs and GMSCs are demonstrated to be ideal cell sources for repairing the damaged tissues of periodontal, muscle, and tendon. Despite the abovementioned applications of oral stem cells, only a few human clinical trials are now underway to use them for the treatment of certain diseases. Since clinical use is the end goal, their true regenerative power and safety need to be further examined.Keywords: oral mesenchymal stem cells, oral epithelial stem cells, cell transplantation, regeneration
format	article
author	Xiao L Nasu M
author_facet	Xiao L Nasu M
author_sort	Xiao L
title	From regenerative dentistry to regenerative medicine: progress, challenges, and potential applications of oral stem cells
title_short	From regenerative dentistry to regenerative medicine: progress, challenges, and potential applications of oral stem cells
title_full	From regenerative dentistry to regenerative medicine: progress, challenges, and potential applications of oral stem cells
title_fullStr	From regenerative dentistry to regenerative medicine: progress, challenges, and potential applications of oral stem cells
title_full_unstemmed	From regenerative dentistry to regenerative medicine: progress, challenges, and potential applications of oral stem cells
title_sort	from regenerative dentistry to regenerative medicine: progress, challenges, and potential applications of oral stem cells
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/882d2c0ab65f40479f23ed31ea2fdabe
work_keys_str_mv	AT xiaol fromregenerativedentistrytoregenerativemedicineprogresschallengesandpotentialapplicationsoforalstemcells AT nasum fromregenerativedentistrytoregenerativemedicineprogresschallengesandpotentialapplicationsoforalstemcells
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From regenerative dentistry to regenerative medicine: progress, challenges, and potential applications of oral stem cells

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