Age-related iron accumulation and demyelination in the basal ganglia are closely related to verbal memory and executive functioning

Abstract Age-related cognitive decline has been linked to alterations of the dopaminergic system and its subcortical trajectories. Recent work suggests a critical role of iron accumulation within the basal ganglia (BG) in verbal memory performance, and increased iron levels have been related to demy...

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Autores principales:	Davina Biel, Tineke K. Steiger, Nico Bunzeck
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/882ea205f5c54818902c582d4284df5f
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spelling	oai:doaj.org-article:882ea205f5c54818902c582d4284df5f2021-12-02T14:41:55ZAge-related iron accumulation and demyelination in the basal ganglia are closely related to verbal memory and executive functioning10.1038/s41598-021-88840-12045-2322https://doaj.org/article/882ea205f5c54818902c582d4284df5f2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88840-1https://doaj.org/toc/2045-2322Abstract Age-related cognitive decline has been linked to alterations of the dopaminergic system and its subcortical trajectories. Recent work suggests a critical role of iron accumulation within the basal ganglia (BG) in verbal memory performance, and increased iron levels have been related to demyelination. However, the specificity of age-related iron increases with respect to cognitive functions remains unclear. Therefore, we investigated the interplay of age, cognitive performance, and structural integrity of the BG. In total, 79 healthy older participants underwent a broad cognitive assessment (fluid and crystallized intelligence, verbal and numeric memory, processing speed, executive functions) and structural MRI. As expected, performance in most cognitive tests had a negative relationship with age. Moreover, BG grey matter volume and magnetization transfer (MT, indicative of myelin) decreased, and R2* (indicative of iron) increased with age. Importantly, R2* and demyelination negatively correlated with verbal memory and executive functions. Within the SN/VTA, age correlated negatively with MT, but there was no clear evidence in favor of a relationship between behavior and R2* or MT. Our results suggest that age-related increases in iron and demyelination within the BG, which are part of a fronto-striatal network, not only impact on verbal memory but also executive functions.Davina BielTineke K. SteigerNico BunzeckNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Davina Biel Tineke K. Steiger Nico Bunzeck Age-related iron accumulation and demyelination in the basal ganglia are closely related to verbal memory and executive functioning
description	Abstract Age-related cognitive decline has been linked to alterations of the dopaminergic system and its subcortical trajectories. Recent work suggests a critical role of iron accumulation within the basal ganglia (BG) in verbal memory performance, and increased iron levels have been related to demyelination. However, the specificity of age-related iron increases with respect to cognitive functions remains unclear. Therefore, we investigated the interplay of age, cognitive performance, and structural integrity of the BG. In total, 79 healthy older participants underwent a broad cognitive assessment (fluid and crystallized intelligence, verbal and numeric memory, processing speed, executive functions) and structural MRI. As expected, performance in most cognitive tests had a negative relationship with age. Moreover, BG grey matter volume and magnetization transfer (MT, indicative of myelin) decreased, and R2* (indicative of iron) increased with age. Importantly, R2* and demyelination negatively correlated with verbal memory and executive functions. Within the SN/VTA, age correlated negatively with MT, but there was no clear evidence in favor of a relationship between behavior and R2* or MT. Our results suggest that age-related increases in iron and demyelination within the BG, which are part of a fronto-striatal network, not only impact on verbal memory but also executive functions.
format	article
author	Davina Biel Tineke K. Steiger Nico Bunzeck
author_facet	Davina Biel Tineke K. Steiger Nico Bunzeck
author_sort	Davina Biel
title	Age-related iron accumulation and demyelination in the basal ganglia are closely related to verbal memory and executive functioning
title_short	Age-related iron accumulation and demyelination in the basal ganglia are closely related to verbal memory and executive functioning
title_full	Age-related iron accumulation and demyelination in the basal ganglia are closely related to verbal memory and executive functioning
title_fullStr	Age-related iron accumulation and demyelination in the basal ganglia are closely related to verbal memory and executive functioning
title_full_unstemmed	Age-related iron accumulation and demyelination in the basal ganglia are closely related to verbal memory and executive functioning
title_sort	age-related iron accumulation and demyelination in the basal ganglia are closely related to verbal memory and executive functioning
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/882ea205f5c54818902c582d4284df5f
work_keys_str_mv	AT davinabiel agerelatedironaccumulationanddemyelinationinthebasalgangliaarecloselyrelatedtoverbalmemoryandexecutivefunctioning AT tinekeksteiger agerelatedironaccumulationanddemyelinationinthebasalgangliaarecloselyrelatedtoverbalmemoryandexecutivefunctioning AT nicobunzeck agerelatedironaccumulationanddemyelinationinthebasalgangliaarecloselyrelatedtoverbalmemoryandexecutivefunctioning
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Age-related iron accumulation and demyelination in the basal ganglia are closely related to verbal memory and executive functioning

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