Effect of Hydro-Methanolic Extract of Sour Orange Flowers, Citrus Aurantium, on Pentylentetrazole Induced Seizure in Male Rats

BACKGROUND AND OBJECTIVE: In Iranian folk medicine, Citrus aurantium flower extract is used to treat some neural diseases such as sleep disorder and anxiety. Tend to use medicinal herbs to treat diseases such as seizure, is growing. The present study was undertaken to evaluate the anticonvulsant eff...

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Autores principales:	M Abbasnejad, B Keramat, S Esmaili Mahani, M Rezaeezade-Roukerd
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2012
Materias:	citrus aurantium seizure rat Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/88337963f505461caf66f47cf1504e5e
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spelling	oai:doaj.org-article:88337963f505461caf66f47cf1504e5e2021-11-10T08:53:26ZEffect of Hydro-Methanolic Extract of Sour Orange Flowers, Citrus Aurantium, on Pentylentetrazole Induced Seizure in Male Rats1561-41072251-7170https://doaj.org/article/88337963f505461caf66f47cf1504e5e2012-09-01T00:00:00Zhttp://jbums.org/article-1-4174-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: In Iranian folk medicine, Citrus aurantium flower extract is used to treat some neural diseases such as sleep disorder and anxiety. Tend to use medicinal herbs to treat diseases such as seizure, is growing. The present study was undertaken to evaluate the anticonvulsant effect of sour orange flowers of Citrus aurantium.METHODS: In this experimental study, 42 adult male Wistar rats (200-250g) were divided into 6 groups: control (PTZ), positive control (phenobarbital) and extract treated groups (75, 150, 300 and 600 mg/kg, i.p,). Fresh sour orange flowers were collected, methanolic extract (70%) was provided by percolator, after the evaporation of methanol, the extract was dried by oven at the 40°C. Pentylentetrazole (90 mg/kg) was used for induction of seizure. Changes in the onset time of seizure, duration of seizure, percent of mortality and percent of seizure protection were determined in different groups and compared with control (PTZ) and positive control (phenobarbital).FINDINGS: The extract (300 mg/kg), significantly reduced the latency of onset of seizure (198±8%) as compared with control (78±3%) (p<0.05), also duration of seizure significantly was reduced by the extract (300mg/kg) (430±46%) compared with control (1350±110%) (p<0.05). Percent of seizure protection significantly was increased by extract in comparison with control group the dose of 600 mg/kg (78±6%) was the most effective dose in compared to control (0%) (p< 0.05). Seizure related mortality was significantly decreased by extract (300 mg/kg) (0%) in compared to control (36%) (p<0.01).CONCLUSION: According to the results of this study, it seems that hydro-methanolic extract of Citrus aurantium can be used to prevent seizures.M Abbasnejad,B KeramatS Esmaili Mahani,M Rezaeezade-RoukerdBabol University of Medical Sciencesarticlecitrus aurantiumseizureratMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 14, Iss 5, Pp 20-28 (2012)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	citrus aurantium seizure rat Medicine R Medicine (General) R5-920
spellingShingle	citrus aurantium seizure rat Medicine R Medicine (General) R5-920 M Abbasnejad, B Keramat S Esmaili Mahani, M Rezaeezade-Roukerd Effect of Hydro-Methanolic Extract of Sour Orange Flowers, Citrus Aurantium, on Pentylentetrazole Induced Seizure in Male Rats
description	BACKGROUND AND OBJECTIVE: In Iranian folk medicine, Citrus aurantium flower extract is used to treat some neural diseases such as sleep disorder and anxiety. Tend to use medicinal herbs to treat diseases such as seizure, is growing. The present study was undertaken to evaluate the anticonvulsant effect of sour orange flowers of Citrus aurantium.METHODS: In this experimental study, 42 adult male Wistar rats (200-250g) were divided into 6 groups: control (PTZ), positive control (phenobarbital) and extract treated groups (75, 150, 300 and 600 mg/kg, i.p,). Fresh sour orange flowers were collected, methanolic extract (70%) was provided by percolator, after the evaporation of methanol, the extract was dried by oven at the 40°C. Pentylentetrazole (90 mg/kg) was used for induction of seizure. Changes in the onset time of seizure, duration of seizure, percent of mortality and percent of seizure protection were determined in different groups and compared with control (PTZ) and positive control (phenobarbital).FINDINGS: The extract (300 mg/kg), significantly reduced the latency of onset of seizure (198±8%) as compared with control (78±3%) (p<0.05), also duration of seizure significantly was reduced by the extract (300mg/kg) (430±46%) compared with control (1350±110%) (p<0.05). Percent of seizure protection significantly was increased by extract in comparison with control group the dose of 600 mg/kg (78±6%) was the most effective dose in compared to control (0%) (p< 0.05). Seizure related mortality was significantly decreased by extract (300 mg/kg) (0%) in compared to control (36%) (p<0.01).CONCLUSION: According to the results of this study, it seems that hydro-methanolic extract of Citrus aurantium can be used to prevent seizures.
format	article
author	M Abbasnejad, B Keramat S Esmaili Mahani, M Rezaeezade-Roukerd
author_facet	M Abbasnejad, B Keramat S Esmaili Mahani, M Rezaeezade-Roukerd
author_sort	M Abbasnejad,
title	Effect of Hydro-Methanolic Extract of Sour Orange Flowers, Citrus Aurantium, on Pentylentetrazole Induced Seizure in Male Rats
title_short	Effect of Hydro-Methanolic Extract of Sour Orange Flowers, Citrus Aurantium, on Pentylentetrazole Induced Seizure in Male Rats
title_full	Effect of Hydro-Methanolic Extract of Sour Orange Flowers, Citrus Aurantium, on Pentylentetrazole Induced Seizure in Male Rats
title_fullStr	Effect of Hydro-Methanolic Extract of Sour Orange Flowers, Citrus Aurantium, on Pentylentetrazole Induced Seizure in Male Rats
title_full_unstemmed	Effect of Hydro-Methanolic Extract of Sour Orange Flowers, Citrus Aurantium, on Pentylentetrazole Induced Seizure in Male Rats
title_sort	effect of hydro-methanolic extract of sour orange flowers, citrus aurantium, on pentylentetrazole induced seizure in male rats
publisher	Babol University of Medical Sciences
publishDate	2012
url	https://doaj.org/article/88337963f505461caf66f47cf1504e5e
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Effect of Hydro-Methanolic Extract of Sour Orange Flowers, Citrus Aurantium, on Pentylentetrazole Induced Seizure in Male Rats

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