Association of FOXO3 Expression with Tumor Pathogenesis, Prognosis and Clinicopathological Features in Hepatocellular Carcinoma: A Systematic Review with Meta-Analysis

Forkhead box O3 (FOXO3), an essential transcription factor related to liver disease, has been linked to cancer progression. The most frequent primary liver tumor, hepatocellular carcinoma (HCC), has an elevated mortality rate and patient outcomes remain very poor. Here, we examined the diagnostic, p...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Flavia Fondevila, Paula Fernández-Palanca, Carolina Méndez-Blanco, Tania Payo-Serafín, Elisa Lozano, Jose J. G. Marin, Javier González-Gallego, José L. Mauriz
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	clinicopathological features diagnosis forkhead box O3 hepatocellular carcinoma prognosis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/8836db6f53a94235ab41f1e0c32f4133
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8836db6f53a94235ab41f1e0c32f4133
record_format	dspace
spelling	oai:doaj.org-article:8836db6f53a94235ab41f1e0c32f41332021-11-11T15:28:52ZAssociation of FOXO3 Expression with Tumor Pathogenesis, Prognosis and Clinicopathological Features in Hepatocellular Carcinoma: A Systematic Review with Meta-Analysis10.3390/cancers132153492072-6694https://doaj.org/article/8836db6f53a94235ab41f1e0c32f41332021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5349https://doaj.org/toc/2072-6694Forkhead box O3 (FOXO3), an essential transcription factor related to liver disease, has been linked to cancer progression. The most frequent primary liver tumor, hepatocellular carcinoma (HCC), has an elevated mortality rate and patient outcomes remain very poor. Here, we examined the diagnostic, prognostic and clinicopathological significance of FOXO3 expression in HCC. We systematically searched Cochrane, Embase, PubMed, Scopus and Web of Science. Articles analyzing FOXO3 levels in HCC patient samples and its relationship with tumor development, survival or clinicopathological factors were selected. Hazard ratios, odds ratios and 95% confidence intervals were extracted, estimated by Parmar method or calculated and pooled across studies. Heterogeneity was evaluated by chi-square-based Q and I<sup>2</sup> tests, while publication bias by funnel plots and Egger’s test. Subgroup analysis was performed when heterogeneity was evident. The study protocol was registered in PROSPERO (CRD42021237321), and data were meta-analyzed employing STATA 16. Five studies involving 1059 HCC cases were finally included in this meta-analysis, finding that high FOXO3 levels significantly correlate with HCC development and shorter overall survival. Moreover, subgroup analysis revealed a significant association between positive FOXO3 expression and the risk of invasion. Thus, FOXO3 could function as a novel biomarker with diagnostic and prognostic value in HCC.Flavia FondevilaPaula Fernández-PalancaCarolina Méndez-BlancoTania Payo-SerafínElisa LozanoJose J. G. MarinJavier González-GallegoJosé L. MaurizMDPI AGarticleclinicopathological featuresdiagnosisforkhead box O3hepatocellular carcinomaprognosisNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5349, p 5349 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	clinicopathological features diagnosis forkhead box O3 hepatocellular carcinoma prognosis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	clinicopathological features diagnosis forkhead box O3 hepatocellular carcinoma prognosis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Flavia Fondevila Paula Fernández-Palanca Carolina Méndez-Blanco Tania Payo-Serafín Elisa Lozano Jose J. G. Marin Javier González-Gallego José L. Mauriz Association of FOXO3 Expression with Tumor Pathogenesis, Prognosis and Clinicopathological Features in Hepatocellular Carcinoma: A Systematic Review with Meta-Analysis
description	Forkhead box O3 (FOXO3), an essential transcription factor related to liver disease, has been linked to cancer progression. The most frequent primary liver tumor, hepatocellular carcinoma (HCC), has an elevated mortality rate and patient outcomes remain very poor. Here, we examined the diagnostic, prognostic and clinicopathological significance of FOXO3 expression in HCC. We systematically searched Cochrane, Embase, PubMed, Scopus and Web of Science. Articles analyzing FOXO3 levels in HCC patient samples and its relationship with tumor development, survival or clinicopathological factors were selected. Hazard ratios, odds ratios and 95% confidence intervals were extracted, estimated by Parmar method or calculated and pooled across studies. Heterogeneity was evaluated by chi-square-based Q and I<sup>2</sup> tests, while publication bias by funnel plots and Egger’s test. Subgroup analysis was performed when heterogeneity was evident. The study protocol was registered in PROSPERO (CRD42021237321), and data were meta-analyzed employing STATA 16. Five studies involving 1059 HCC cases were finally included in this meta-analysis, finding that high FOXO3 levels significantly correlate with HCC development and shorter overall survival. Moreover, subgroup analysis revealed a significant association between positive FOXO3 expression and the risk of invasion. Thus, FOXO3 could function as a novel biomarker with diagnostic and prognostic value in HCC.
format	article
author	Flavia Fondevila Paula Fernández-Palanca Carolina Méndez-Blanco Tania Payo-Serafín Elisa Lozano Jose J. G. Marin Javier González-Gallego José L. Mauriz
author_facet	Flavia Fondevila Paula Fernández-Palanca Carolina Méndez-Blanco Tania Payo-Serafín Elisa Lozano Jose J. G. Marin Javier González-Gallego José L. Mauriz
author_sort	Flavia Fondevila
title	Association of FOXO3 Expression with Tumor Pathogenesis, Prognosis and Clinicopathological Features in Hepatocellular Carcinoma: A Systematic Review with Meta-Analysis
title_short	Association of FOXO3 Expression with Tumor Pathogenesis, Prognosis and Clinicopathological Features in Hepatocellular Carcinoma: A Systematic Review with Meta-Analysis
title_full	Association of FOXO3 Expression with Tumor Pathogenesis, Prognosis and Clinicopathological Features in Hepatocellular Carcinoma: A Systematic Review with Meta-Analysis
title_fullStr	Association of FOXO3 Expression with Tumor Pathogenesis, Prognosis and Clinicopathological Features in Hepatocellular Carcinoma: A Systematic Review with Meta-Analysis
title_full_unstemmed	Association of FOXO3 Expression with Tumor Pathogenesis, Prognosis and Clinicopathological Features in Hepatocellular Carcinoma: A Systematic Review with Meta-Analysis
title_sort	association of foxo3 expression with tumor pathogenesis, prognosis and clinicopathological features in hepatocellular carcinoma: a systematic review with meta-analysis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/8836db6f53a94235ab41f1e0c32f4133
work_keys_str_mv	AT flaviafondevila associationoffoxo3expressionwithtumorpathogenesisprognosisandclinicopathologicalfeaturesinhepatocellularcarcinomaasystematicreviewwithmetaanalysis AT paulafernandezpalanca associationoffoxo3expressionwithtumorpathogenesisprognosisandclinicopathologicalfeaturesinhepatocellularcarcinomaasystematicreviewwithmetaanalysis AT carolinamendezblanco associationoffoxo3expressionwithtumorpathogenesisprognosisandclinicopathologicalfeaturesinhepatocellularcarcinomaasystematicreviewwithmetaanalysis AT taniapayoserafin associationoffoxo3expressionwithtumorpathogenesisprognosisandclinicopathologicalfeaturesinhepatocellularcarcinomaasystematicreviewwithmetaanalysis AT elisalozano associationoffoxo3expressionwithtumorpathogenesisprognosisandclinicopathologicalfeaturesinhepatocellularcarcinomaasystematicreviewwithmetaanalysis AT josejgmarin associationoffoxo3expressionwithtumorpathogenesisprognosisandclinicopathologicalfeaturesinhepatocellularcarcinomaasystematicreviewwithmetaanalysis AT javiergonzalezgallego associationoffoxo3expressionwithtumorpathogenesisprognosisandclinicopathologicalfeaturesinhepatocellularcarcinomaasystematicreviewwithmetaanalysis AT joselmauriz associationoffoxo3expressionwithtumorpathogenesisprognosisandclinicopathologicalfeaturesinhepatocellularcarcinomaasystematicreviewwithmetaanalysis
_version_	1718435250903711744

Association of FOXO3 Expression with Tumor Pathogenesis, Prognosis and Clinicopathological Features in Hepatocellular Carcinoma: A Systematic Review with Meta-Analysis

Ejemplares similares