Antimicrobial peptide capsids of de novo design

With the growing threat of antibiotic resistance, unconventional approaches to antimicrobial discovery are needed. Here, the authors present a peptide topology that mimics virus architecture and assembles into antimicrobial capsids that disrupt bacterial membranes upon contact.

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Autores principales:	Emiliana De Santis, Hasan Alkassem, Baptiste Lamarre, Nilofar Faruqui, Angelo Bella, James E. Noble, Nicola Micale, Santanu Ray, Jonathan R. Burns, Alexander R. Yon, Bart W. Hoogenboom, Maxim G. Ryadnov
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/88371df5dcef4efcb2b2ca3aa1e6c301
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spelling	oai:doaj.org-article:88371df5dcef4efcb2b2ca3aa1e6c3012021-12-02T15:38:43ZAntimicrobial peptide capsids of de novo design10.1038/s41467-017-02475-32041-1723https://doaj.org/article/88371df5dcef4efcb2b2ca3aa1e6c3012017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02475-3https://doaj.org/toc/2041-1723With the growing threat of antibiotic resistance, unconventional approaches to antimicrobial discovery are needed. Here, the authors present a peptide topology that mimics virus architecture and assembles into antimicrobial capsids that disrupt bacterial membranes upon contact.Emiliana De SantisHasan AlkassemBaptiste LamarreNilofar FaruquiAngelo BellaJames E. NobleNicola MicaleSantanu RayJonathan R. BurnsAlexander R. YonBart W. HoogenboomMaxim G. RyadnovNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Emiliana De Santis Hasan Alkassem Baptiste Lamarre Nilofar Faruqui Angelo Bella James E. Noble Nicola Micale Santanu Ray Jonathan R. Burns Alexander R. Yon Bart W. Hoogenboom Maxim G. Ryadnov Antimicrobial peptide capsids of de novo design
description	With the growing threat of antibiotic resistance, unconventional approaches to antimicrobial discovery are needed. Here, the authors present a peptide topology that mimics virus architecture and assembles into antimicrobial capsids that disrupt bacterial membranes upon contact.
format	article
author	Emiliana De Santis Hasan Alkassem Baptiste Lamarre Nilofar Faruqui Angelo Bella James E. Noble Nicola Micale Santanu Ray Jonathan R. Burns Alexander R. Yon Bart W. Hoogenboom Maxim G. Ryadnov
author_facet	Emiliana De Santis Hasan Alkassem Baptiste Lamarre Nilofar Faruqui Angelo Bella James E. Noble Nicola Micale Santanu Ray Jonathan R. Burns Alexander R. Yon Bart W. Hoogenboom Maxim G. Ryadnov
author_sort	Emiliana De Santis
title	Antimicrobial peptide capsids of de novo design
title_short	Antimicrobial peptide capsids of de novo design
title_full	Antimicrobial peptide capsids of de novo design
title_fullStr	Antimicrobial peptide capsids of de novo design
title_full_unstemmed	Antimicrobial peptide capsids of de novo design
title_sort	antimicrobial peptide capsids of de novo design
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/88371df5dcef4efcb2b2ca3aa1e6c301
work_keys_str_mv	AT emilianadesantis antimicrobialpeptidecapsidsofdenovodesign AT hasanalkassem antimicrobialpeptidecapsidsofdenovodesign AT baptistelamarre antimicrobialpeptidecapsidsofdenovodesign AT nilofarfaruqui antimicrobialpeptidecapsidsofdenovodesign AT angelobella antimicrobialpeptidecapsidsofdenovodesign AT jamesenoble antimicrobialpeptidecapsidsofdenovodesign AT nicolamicale antimicrobialpeptidecapsidsofdenovodesign AT santanuray antimicrobialpeptidecapsidsofdenovodesign AT jonathanrburns antimicrobialpeptidecapsidsofdenovodesign AT alexanderryon antimicrobialpeptidecapsidsofdenovodesign AT bartwhoogenboom antimicrobialpeptidecapsidsofdenovodesign AT maximgryadnov antimicrobialpeptidecapsidsofdenovodesign
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Antimicrobial peptide capsids of de novo design

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