Regulation of the DNA damage response and gene expression by the Dot1L histone methyltransferase and the 53Bp1 tumour suppressor.

Regulation of the DNA damage response and gene expression by the Dot1L histone methyltransferase and the 53Bp1 tumour suppressor.

<h4>Background</h4>Dot1L, a histone methyltransferase that targets histone H3 lysine 79 (H3K79), has been implicated in gene regulation and the DNA damage response although its functions in these processes remain poorly defined.<h4>Methodology/principal findings</h4>Using the...

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Autores principales: Jennifer FitzGerald, Sylvie Moureau, Paul Drogaris, Enda O'Connell, Nebiyu Abshiru, Alain Verreault, Pierre Thibault, Muriel Grenon, Noel F Lowndes
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/88377b771a5243508fc14e3367b752f9
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