Cumulative Inflammation and HbA1c Levels Correlate with Increased Intima-Media Thickness in Patients with Severe Hidradenitis Suppurativa

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease that has been associated with a greater risk of metabolic and cardiovascular comorbidities. The aim of this study is to assess cardiovascular risk by means of intima-media thickness (IMT), metabolic syndrome, and other potential bi...

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Autores principales:	Manuel Sánchez-Díaz, Luis Salvador-Rodríguez, Trinidad Montero-Vílchez, Antonio Martínez-López, Salvador Arias-Santiago, Alejandro Molina-Leyva
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	hidradenitis suppurativa cardiovascular risk intima-media thickness Medicine R
Acceso en línea:	https://doaj.org/article/8837dae578744744a457412a3d9fc664
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spelling	oai:doaj.org-article:8837dae578744744a457412a3d9fc6642021-11-25T18:00:36ZCumulative Inflammation and HbA1c Levels Correlate with Increased Intima-Media Thickness in Patients with Severe Hidradenitis Suppurativa10.3390/jcm102252222077-0383https://doaj.org/article/8837dae578744744a457412a3d9fc6642021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/22/5222https://doaj.org/toc/2077-0383Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease that has been associated with a greater risk of metabolic and cardiovascular comorbidities. The aim of this study is to assess cardiovascular risk by means of intima-media thickness (IMT), metabolic syndrome, and other potential biomarkers in patients with severe hidradenitis suppurativa who are candidates for biologic therapy and to explore potentially associated factors. A cross-sectional study was performed. Body mass index (BMI), carotid intima-media thickness (IMT), and blood tests, including glycemic and lipid profile, insulin, vitamin D, and inflammation markers were performed. Fifty patients were included in the study; the male/female ratio was 3:2. The mean age was 38 years, and the mean disease duration was 21.8 years. The mean carotid IMT was 651.39 μm. A positive association of IMT with disease duration, tobacco consumption, and HbA1c levels was observed. HbA1c correlated with the age of onset, hypertension, metabolic syndrome, and glucose levels. Vitamin D levels inversely correlated with the number of areas affected. In conclusion, patients with severe HS present a higher cardiovascular risk, but it is not distributed equally within the patients: Tobacco consumption, inadequate glycemic control, and disease duration could be useful clinical and biochemical markers to identify patients at higher risk.Manuel Sánchez-DíazLuis Salvador-RodríguezTrinidad Montero-VílchezAntonio Martínez-LópezSalvador Arias-SantiagoAlejandro Molina-LeyvaMDPI AGarticlehidradenitis suppurativacardiovascular riskintima-media thicknessMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5222, p 5222 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hidradenitis suppurativa cardiovascular risk intima-media thickness Medicine R
spellingShingle	hidradenitis suppurativa cardiovascular risk intima-media thickness Medicine R Manuel Sánchez-Díaz Luis Salvador-Rodríguez Trinidad Montero-Vílchez Antonio Martínez-López Salvador Arias-Santiago Alejandro Molina-Leyva Cumulative Inflammation and HbA1c Levels Correlate with Increased Intima-Media Thickness in Patients with Severe Hidradenitis Suppurativa
description	Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease that has been associated with a greater risk of metabolic and cardiovascular comorbidities. The aim of this study is to assess cardiovascular risk by means of intima-media thickness (IMT), metabolic syndrome, and other potential biomarkers in patients with severe hidradenitis suppurativa who are candidates for biologic therapy and to explore potentially associated factors. A cross-sectional study was performed. Body mass index (BMI), carotid intima-media thickness (IMT), and blood tests, including glycemic and lipid profile, insulin, vitamin D, and inflammation markers were performed. Fifty patients were included in the study; the male/female ratio was 3:2. The mean age was 38 years, and the mean disease duration was 21.8 years. The mean carotid IMT was 651.39 μm. A positive association of IMT with disease duration, tobacco consumption, and HbA1c levels was observed. HbA1c correlated with the age of onset, hypertension, metabolic syndrome, and glucose levels. Vitamin D levels inversely correlated with the number of areas affected. In conclusion, patients with severe HS present a higher cardiovascular risk, but it is not distributed equally within the patients: Tobacco consumption, inadequate glycemic control, and disease duration could be useful clinical and biochemical markers to identify patients at higher risk.
format	article
author	Manuel Sánchez-Díaz Luis Salvador-Rodríguez Trinidad Montero-Vílchez Antonio Martínez-López Salvador Arias-Santiago Alejandro Molina-Leyva
author_facet	Manuel Sánchez-Díaz Luis Salvador-Rodríguez Trinidad Montero-Vílchez Antonio Martínez-López Salvador Arias-Santiago Alejandro Molina-Leyva
author_sort	Manuel Sánchez-Díaz
title	Cumulative Inflammation and HbA1c Levels Correlate with Increased Intima-Media Thickness in Patients with Severe Hidradenitis Suppurativa
title_short	Cumulative Inflammation and HbA1c Levels Correlate with Increased Intima-Media Thickness in Patients with Severe Hidradenitis Suppurativa
title_full	Cumulative Inflammation and HbA1c Levels Correlate with Increased Intima-Media Thickness in Patients with Severe Hidradenitis Suppurativa
title_fullStr	Cumulative Inflammation and HbA1c Levels Correlate with Increased Intima-Media Thickness in Patients with Severe Hidradenitis Suppurativa
title_full_unstemmed	Cumulative Inflammation and HbA1c Levels Correlate with Increased Intima-Media Thickness in Patients with Severe Hidradenitis Suppurativa
title_sort	cumulative inflammation and hba1c levels correlate with increased intima-media thickness in patients with severe hidradenitis suppurativa
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/8837dae578744744a457412a3d9fc664
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Cumulative Inflammation and HbA1c Levels Correlate with Increased Intima-Media Thickness in Patients with Severe Hidradenitis Suppurativa

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