Targeting PFKFB3 alleviates cerebral ischemia-reperfusion injury in mice

Targeting PFKFB3 alleviates cerebral ischemia-reperfusion injury in mice

Abstract The glycolytic rate in neurons is low in order to allow glucose to be metabolized through the pentose-phosphate pathway (PPP), which regenerates NADPH to preserve the glutathione redox status and survival. This is controlled by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3)...

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Autores principales: Olga Burmistrova, Ana Olias-Arjona, Rebeca Lapresa, Daniel Jimenez-Blasco, Tatiana Eremeeva, Dmitry Shishov, Sergei Romanov, Kristina Zakurdaeva, Angeles Almeida, Peter O. Fedichev, Juan P. Bolaños
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Medicine
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Science
Q
Acceso en línea:https://doaj.org/article/883ca8c766f94de9a52ed1902af7bd39
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