PTENβ is an alternatively translated isoform of PTEN that regulates rDNA transcription
PTEN is a potent tumour suppressor involved in cell growth, proliferation and survival. Here the authors identify an N-terminal extended isoform of PTEN, termed PTENβ that negatively regulates ribosomal DNA transcription and cell proliferation, expanding the pleiotropic functions of the PTEN family....
Guardado en:
Autores principales: | Hui Liang, Xi Chen, Qi Yin, Danhui Ruan, Xuyang Zhao, Cong Zhang, Michael A. McNutt, Yuxin Yin |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2017
|
Materias: | |
Acceso en línea: | https://doaj.org/article/883da98b6f924e5d8e3d415cd77b2dab |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
PTENα functions as an immune suppressor and promotes immune resistance in PTEN-mutant cancer
por: Yizhe Sun, et al.
Publicado: (2021) -
circPTEN suppresses colorectal cancer progression through regulating PTEN/AKT pathway
por: Chen Li, et al.
Publicado: (2021) -
PTEN regulates EG5 to control spindle architecture and chromosome congression during mitosis
por: Jinxue He, et al.
Publicado: (2016) -
Nuclear PTEN functions as an essential regulator of SRF-dependent transcription to control smooth muscle differentiation
por: Henrick Horita, et al.
Publicado: (2016) -
FBXO22 degrades nuclear PTEN to promote tumorigenesis
por: Meng-Kai Ge, et al.
Publicado: (2020)