Quantitative trait loci (QTL) associated with resistance to a monogenean parasite (Benedenia seriolae) in yellowtail (Seriola quinqueradiata) through genome wide analysis.

Benedenia infections caused by the monogenean fluke ectoparasite Benedenia seriolae seriously impact marine finfish aquaculture. Genetic variation has been inferred to play a significant role in determining the susceptibility to this parasitic disease. To evaluate the genetic basis of Benedenia dise...

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Autores principales:	Akiyuki Ozaki, Kazunori Yoshida, Kanako Fuji, Satoshi Kubota, Wataru Kai, Jun-ya Aoki, Yumi Kawabata, Junpei Suzuki, Kazuki Akita, Takashi Koyama, Masahiro Nakagawa, Takurou Hotta, Tatsuo Tsuzaki, Nobuaki Okamoto, Kazuo Araki, Takashi Sakamoto
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/88446be63af24a1ba18c3f57c8372c14
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spelling	oai:doaj.org-article:88446be63af24a1ba18c3f57c8372c142021-11-18T07:43:07ZQuantitative trait loci (QTL) associated with resistance to a monogenean parasite (Benedenia seriolae) in yellowtail (Seriola quinqueradiata) through genome wide analysis.1932-620310.1371/journal.pone.0064987https://doaj.org/article/88446be63af24a1ba18c3f57c8372c142013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23750223/?tool=EBIhttps://doaj.org/toc/1932-6203Benedenia infections caused by the monogenean fluke ectoparasite Benedenia seriolae seriously impact marine finfish aquaculture. Genetic variation has been inferred to play a significant role in determining the susceptibility to this parasitic disease. To evaluate the genetic basis of Benedenia disease resistance in yellowtail (Seriola quinqueradiata), a genome-wide and chromosome-wide linkage analyses were initiated using F1 yellowtail families (n = 90 per family) based on a high-density linkage map with 860 microsatellite and 142 single nucleotide polymorphism (SNP) markers. Two major quantitative trait loci (QTL) regions on linkage groups Squ2 (BDR-1) and Squ20 (BDR-2) were identified. These QTL regions explained 32.9-35.5% of the phenotypic variance. On the other hand, we investigated the relationship between QTL for susceptibility to B. seriolae and QTL for fish body size. The QTL related to growth was found on another linkage group (Squ7). As a result, this is the first genetic evidence that contributes to detailing phenotypic resistance to Benedenia disease, and the results will help resolve the mechanism of resistance to this important parasitic infection of yellowtail.Akiyuki OzakiKazunori YoshidaKanako FujiSatoshi KubotaWataru KaiJun-ya AokiYumi KawabataJunpei SuzukiKazuki AkitaTakashi KoyamaMasahiro NakagawaTakurou HottaTatsuo TsuzakiNobuaki OkamotoKazuo ArakiTakashi SakamotoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 6, p e64987 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Akiyuki Ozaki Kazunori Yoshida Kanako Fuji Satoshi Kubota Wataru Kai Jun-ya Aoki Yumi Kawabata Junpei Suzuki Kazuki Akita Takashi Koyama Masahiro Nakagawa Takurou Hotta Tatsuo Tsuzaki Nobuaki Okamoto Kazuo Araki Takashi Sakamoto Quantitative trait loci (QTL) associated with resistance to a monogenean parasite (Benedenia seriolae) in yellowtail (Seriola quinqueradiata) through genome wide analysis.
description	Benedenia infections caused by the monogenean fluke ectoparasite Benedenia seriolae seriously impact marine finfish aquaculture. Genetic variation has been inferred to play a significant role in determining the susceptibility to this parasitic disease. To evaluate the genetic basis of Benedenia disease resistance in yellowtail (Seriola quinqueradiata), a genome-wide and chromosome-wide linkage analyses were initiated using F1 yellowtail families (n = 90 per family) based on a high-density linkage map with 860 microsatellite and 142 single nucleotide polymorphism (SNP) markers. Two major quantitative trait loci (QTL) regions on linkage groups Squ2 (BDR-1) and Squ20 (BDR-2) were identified. These QTL regions explained 32.9-35.5% of the phenotypic variance. On the other hand, we investigated the relationship between QTL for susceptibility to B. seriolae and QTL for fish body size. The QTL related to growth was found on another linkage group (Squ7). As a result, this is the first genetic evidence that contributes to detailing phenotypic resistance to Benedenia disease, and the results will help resolve the mechanism of resistance to this important parasitic infection of yellowtail.
format	article
author	Akiyuki Ozaki Kazunori Yoshida Kanako Fuji Satoshi Kubota Wataru Kai Jun-ya Aoki Yumi Kawabata Junpei Suzuki Kazuki Akita Takashi Koyama Masahiro Nakagawa Takurou Hotta Tatsuo Tsuzaki Nobuaki Okamoto Kazuo Araki Takashi Sakamoto
author_facet	Akiyuki Ozaki Kazunori Yoshida Kanako Fuji Satoshi Kubota Wataru Kai Jun-ya Aoki Yumi Kawabata Junpei Suzuki Kazuki Akita Takashi Koyama Masahiro Nakagawa Takurou Hotta Tatsuo Tsuzaki Nobuaki Okamoto Kazuo Araki Takashi Sakamoto
author_sort	Akiyuki Ozaki
title	Quantitative trait loci (QTL) associated with resistance to a monogenean parasite (Benedenia seriolae) in yellowtail (Seriola quinqueradiata) through genome wide analysis.
title_short	Quantitative trait loci (QTL) associated with resistance to a monogenean parasite (Benedenia seriolae) in yellowtail (Seriola quinqueradiata) through genome wide analysis.
title_full	Quantitative trait loci (QTL) associated with resistance to a monogenean parasite (Benedenia seriolae) in yellowtail (Seriola quinqueradiata) through genome wide analysis.
title_fullStr	Quantitative trait loci (QTL) associated with resistance to a monogenean parasite (Benedenia seriolae) in yellowtail (Seriola quinqueradiata) through genome wide analysis.
title_full_unstemmed	Quantitative trait loci (QTL) associated with resistance to a monogenean parasite (Benedenia seriolae) in yellowtail (Seriola quinqueradiata) through genome wide analysis.
title_sort	quantitative trait loci (qtl) associated with resistance to a monogenean parasite (benedenia seriolae) in yellowtail (seriola quinqueradiata) through genome wide analysis.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/88446be63af24a1ba18c3f57c8372c14
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Quantitative trait loci (QTL) associated with resistance to a monogenean parasite (Benedenia seriolae) in yellowtail (Seriola quinqueradiata) through genome wide analysis.

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