Deficiency of ASGR1 in pigs recapitulates reduced risk factor for cardiovascular disease in humans

Deficiency of ASGR1 in pigs recapitulates reduced risk factor for cardiovascular disease in humans

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Genetic variants in the asialoglycoprotein receptor 1 (ASGR1) are associated with a reduced risk of cardiovascular disease (CVD) in humans. However, the underlying molecular mechanism remains elusive. Given the cardiovascular similarities between pigs and humans, we generated ASGR1-deficient pigs us...

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Autores principales: Baocai Xie, Xiaochen Shi, Yan Li, Bo Xia, Jia Zhou, Minjie Du, Xiangyang Xing, Liang Bai, Enqi Liu, Fernando Alvarez, Long Jin, Shaoping Deng, Grant A. Mitchell, Dengke Pan, Mingzhou Li, Jiangwei Wu
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
Materias:
Genetics
QH426-470
Acceso en línea:https://doaj.org/article/8844bd7497d64e73ab87e18292a072e0
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