Corneal biomechanical parameters and intraocular pressure: the effect of topical anesthesia

Kelechi C OgbuehiCornea Research Chair, Department of Optometry and Vision Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi ArabiaBackground: The intraocular pressures and biomechanical parameters measured by the ocular response analyzer make the analyzer a useful t...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autor principal:	Ogbuehi KC
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/88475f18331548ecbcbfe3186cafaaaf
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:88475f18331548ecbcbfe3186cafaaaf
record_format	dspace
spelling	oai:doaj.org-article:88475f18331548ecbcbfe3186cafaaaf2021-12-02T02:59:31ZCorneal biomechanical parameters and intraocular pressure: the effect of topical anesthesia1177-54671177-5483https://doaj.org/article/88475f18331548ecbcbfe3186cafaaaf2012-06-01T00:00:00Zhttp://www.dovepress.com/corneal-biomechanical-parameters-and-intraocular-pressure-the-effect-o-a10122https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Kelechi C OgbuehiCornea Research Chair, Department of Optometry and Vision Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi ArabiaBackground: The intraocular pressures and biomechanical parameters measured by the ocular response analyzer make the analyzer a useful tool for the diagnosis and management of anterior segment disease. This observational study was designed to investigate the effect of topical anesthesia on the parameters measured by the ocular response analyzer: corneal hysteresis, corneal resistance factor, Goldmann-correlated intraocular pressure (IOPg), and corneal-compensated intraocular pressure (IOPcc).Methods: Two sets of measurements were made for 78 eyes of 39 subjects, approximately 1 week apart. In session 1, each eye of each subject was randomized into one of three groups: polyvinyl alcohol (0.5%), tetracaine hydrochloride (0.5%), or oxybuprocaine hydrochloride (0.4%). In session 2, eyes that were in the polyvinyl alcohol group in session 1 were assigned to the tetracaine group, those in the tetracaine group in session 1 were assigned to oxybuprocaine group, and those in the oxybuprocaine group in session 1 were assigned to the polyvinyl alcohol group. For both sessions, each subject first had his or her central corneal thickness assessed with a specular microscope, followed by measurements of intraocular pressure and corneal biomechanical parameters with the Ocular Response Analyzer. All measurements were repeated for 2 minutes and 5 minutes following the instillation of either polyvinyl alcohol, tetracaine, or oxybuprocaine. The level of statistical significance was 0.05.Results: Polyvinyl alcohol, tetracaine hydrochloride, and oxybuprocaine hydrochloride had no statistically significant (P &gt; 0.05) effect on any of the biomechanical parameters of the cornea. There was no statistically significant effect on either IOPg (P &gt; 0.05) or IOPcc (P &gt; 0.05) 2 minutes after the eye drops were instilled in either session. Five minutes after the eye drops were instilled, polyvinyl alcohol showed no statistically significant effect on either IOPg (P &gt; 0.05) or IOPcc (P &gt; 0.05) in either session. Oxybuprocaine and tetracaine caused statistically significant (P &lt; 0.05) reductions in IOPg in session 1, but only tetracaine had a significant (P &lt; 0.05) effect in session 2. Tetracaine also caused a statistically significant (P &lt; 0.05) reduction in IOPcc in session 1.Conclusion: The statistically significant effect of topical anesthesia on IOPg varies with the anesthetic used, and while this effect was statistically significant in this study, the small effect is probably not clinically relevant. There was no effect on any of the biomechanical parameters of the cornea.Keywords: intraocular pressure, ocular response analyzer, corneal biomechanical parameters, corneal hysteresis, corneal resistance factor, topical anesthesiaOgbuehi KCDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2012, Iss default, Pp 871-878 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Ogbuehi KC Corneal biomechanical parameters and intraocular pressure: the effect of topical anesthesia
description	Kelechi C OgbuehiCornea Research Chair, Department of Optometry and Vision Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi ArabiaBackground: The intraocular pressures and biomechanical parameters measured by the ocular response analyzer make the analyzer a useful tool for the diagnosis and management of anterior segment disease. This observational study was designed to investigate the effect of topical anesthesia on the parameters measured by the ocular response analyzer: corneal hysteresis, corneal resistance factor, Goldmann-correlated intraocular pressure (IOPg), and corneal-compensated intraocular pressure (IOPcc).Methods: Two sets of measurements were made for 78 eyes of 39 subjects, approximately 1 week apart. In session 1, each eye of each subject was randomized into one of three groups: polyvinyl alcohol (0.5%), tetracaine hydrochloride (0.5%), or oxybuprocaine hydrochloride (0.4%). In session 2, eyes that were in the polyvinyl alcohol group in session 1 were assigned to the tetracaine group, those in the tetracaine group in session 1 were assigned to oxybuprocaine group, and those in the oxybuprocaine group in session 1 were assigned to the polyvinyl alcohol group. For both sessions, each subject first had his or her central corneal thickness assessed with a specular microscope, followed by measurements of intraocular pressure and corneal biomechanical parameters with the Ocular Response Analyzer. All measurements were repeated for 2 minutes and 5 minutes following the instillation of either polyvinyl alcohol, tetracaine, or oxybuprocaine. The level of statistical significance was 0.05.Results: Polyvinyl alcohol, tetracaine hydrochloride, and oxybuprocaine hydrochloride had no statistically significant (P &gt; 0.05) effect on any of the biomechanical parameters of the cornea. There was no statistically significant effect on either IOPg (P &gt; 0.05) or IOPcc (P &gt; 0.05) 2 minutes after the eye drops were instilled in either session. Five minutes after the eye drops were instilled, polyvinyl alcohol showed no statistically significant effect on either IOPg (P &gt; 0.05) or IOPcc (P &gt; 0.05) in either session. Oxybuprocaine and tetracaine caused statistically significant (P &lt; 0.05) reductions in IOPg in session 1, but only tetracaine had a significant (P &lt; 0.05) effect in session 2. Tetracaine also caused a statistically significant (P &lt; 0.05) reduction in IOPcc in session 1.Conclusion: The statistically significant effect of topical anesthesia on IOPg varies with the anesthetic used, and while this effect was statistically significant in this study, the small effect is probably not clinically relevant. There was no effect on any of the biomechanical parameters of the cornea.Keywords: intraocular pressure, ocular response analyzer, corneal biomechanical parameters, corneal hysteresis, corneal resistance factor, topical anesthesia
format	article
author	Ogbuehi KC
author_facet	Ogbuehi KC
author_sort	Ogbuehi KC
title	Corneal biomechanical parameters and intraocular pressure: the effect of topical anesthesia
title_short	Corneal biomechanical parameters and intraocular pressure: the effect of topical anesthesia
title_full	Corneal biomechanical parameters and intraocular pressure: the effect of topical anesthesia
title_fullStr	Corneal biomechanical parameters and intraocular pressure: the effect of topical anesthesia
title_full_unstemmed	Corneal biomechanical parameters and intraocular pressure: the effect of topical anesthesia
title_sort	corneal biomechanical parameters and intraocular pressure: the effect of topical anesthesia
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/88475f18331548ecbcbfe3186cafaaaf
work_keys_str_mv	AT ogbuehikc cornealbiomechanicalparametersandintraocularpressuretheeffectoftopicalanesthesia
_version_	1718401995439603712

Corneal biomechanical parameters and intraocular pressure: the effect of topical anesthesia

Ejemplares similares