Comparative transcriptomic analysis of Gardnerella vaginalis biofilms vs. planktonic cultures using RNA-seq

Vaginal infection: Gene activity protects biofilms Altered gene activity may promote chronic and recurrent infections in the most common gynecological disorder in women of reproductive age. Bacterial vaginosis (BV) frequently involves the formation of biofilms by Gardnerella vaginalis bacteria. Nuno...

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Autores principales:	Joana Castro, Angela França, Katie R. Bradwell, Myrna G. Serrano, Kimberly K. Jefferson, Nuno Cerca
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Microbial ecology QR100-130
Acceso en línea:	https://doaj.org/article/884fc4a6dd9a46e193afb897f145d51c
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spelling	oai:doaj.org-article:884fc4a6dd9a46e193afb897f145d51c2021-12-02T16:09:13ZComparative transcriptomic analysis of Gardnerella vaginalis biofilms vs. planktonic cultures using RNA-seq10.1038/s41522-017-0012-72055-5008https://doaj.org/article/884fc4a6dd9a46e193afb897f145d51c2017-02-01T00:00:00Zhttps://doi.org/10.1038/s41522-017-0012-7https://doaj.org/toc/2055-5008Vaginal infection: Gene activity protects biofilms Altered gene activity may promote chronic and recurrent infections in the most common gynecological disorder in women of reproductive age. Bacterial vaginosis (BV) frequently involves the formation of biofilms by Gardnerella vaginalis bacteria. Nuno Cerca and colleagues at the University of Minho in Portugal, with co-workers elsewhere in Portugal and in the USA, studied changes in gene activity in BV biofilms. Their results linked differences in the activity of 815 genes to an ability of the bacteria to enter a protected form of growth when producing biofilms. The differences included increased activity of specific genes associated with antibiotic resistance. This insight into the bacterial ability to undergo drastic changes in gene activity could guide work to understand chronic and recurrent BV. It may also lead to new ways to treat this common and troublesome condition.Joana CastroAngela FrançaKatie R. BradwellMyrna G. SerranoKimberly K. JeffersonNuno CercaNature PortfolioarticleMicrobial ecologyQR100-130ENnpj Biofilms and Microbiomes, Vol 3, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbial ecology QR100-130
spellingShingle	Microbial ecology QR100-130 Joana Castro Angela França Katie R. Bradwell Myrna G. Serrano Kimberly K. Jefferson Nuno Cerca Comparative transcriptomic analysis of Gardnerella vaginalis biofilms vs. planktonic cultures using RNA-seq
description	Vaginal infection: Gene activity protects biofilms Altered gene activity may promote chronic and recurrent infections in the most common gynecological disorder in women of reproductive age. Bacterial vaginosis (BV) frequently involves the formation of biofilms by Gardnerella vaginalis bacteria. Nuno Cerca and colleagues at the University of Minho in Portugal, with co-workers elsewhere in Portugal and in the USA, studied changes in gene activity in BV biofilms. Their results linked differences in the activity of 815 genes to an ability of the bacteria to enter a protected form of growth when producing biofilms. The differences included increased activity of specific genes associated with antibiotic resistance. This insight into the bacterial ability to undergo drastic changes in gene activity could guide work to understand chronic and recurrent BV. It may also lead to new ways to treat this common and troublesome condition.
format	article
author	Joana Castro Angela França Katie R. Bradwell Myrna G. Serrano Kimberly K. Jefferson Nuno Cerca
author_facet	Joana Castro Angela França Katie R. Bradwell Myrna G. Serrano Kimberly K. Jefferson Nuno Cerca
author_sort	Joana Castro
title	Comparative transcriptomic analysis of Gardnerella vaginalis biofilms vs. planktonic cultures using RNA-seq
title_short	Comparative transcriptomic analysis of Gardnerella vaginalis biofilms vs. planktonic cultures using RNA-seq
title_full	Comparative transcriptomic analysis of Gardnerella vaginalis biofilms vs. planktonic cultures using RNA-seq
title_fullStr	Comparative transcriptomic analysis of Gardnerella vaginalis biofilms vs. planktonic cultures using RNA-seq
title_full_unstemmed	Comparative transcriptomic analysis of Gardnerella vaginalis biofilms vs. planktonic cultures using RNA-seq
title_sort	comparative transcriptomic analysis of gardnerella vaginalis biofilms vs. planktonic cultures using rna-seq
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/884fc4a6dd9a46e193afb897f145d51c
work_keys_str_mv	AT joanacastro comparativetranscriptomicanalysisofgardnerellavaginalisbiofilmsvsplanktonicculturesusingrnaseq AT angelafranca comparativetranscriptomicanalysisofgardnerellavaginalisbiofilmsvsplanktonicculturesusingrnaseq AT katierbradwell comparativetranscriptomicanalysisofgardnerellavaginalisbiofilmsvsplanktonicculturesusingrnaseq AT myrnagserrano comparativetranscriptomicanalysisofgardnerellavaginalisbiofilmsvsplanktonicculturesusingrnaseq AT kimberlykjefferson comparativetranscriptomicanalysisofgardnerellavaginalisbiofilmsvsplanktonicculturesusingrnaseq AT nunocerca comparativetranscriptomicanalysisofgardnerellavaginalisbiofilmsvsplanktonicculturesusingrnaseq
_version_	1718384482384347136

Comparative transcriptomic analysis of Gardnerella vaginalis biofilms vs. planktonic cultures using RNA-seq

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