Trafficking, localization and degradation of the Na+,HCO3 − co-transporter NBCn1 in kidney and breast epithelial cells

Trafficking, localization and degradation of the Na+,HCO3 − co-transporter NBCn1 in kidney and breast epithelial cells

Abstract The Na+;HCO3− co-transporter NBCn1 (SLC4A7) is a major regulator of intracellular pH yet its trafficking and turnover are essentially unstudied. Here, we used MDCK-II and MCF-7 cells to investigate these processes in epithelial cells. GFP-NBCn1 membrane localization was abolished by truncat...

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Autores principales: Christina Wilkens Olesen, Jens Vogensen, Ida Axholm, Marc Severin, Julie Schnipper, Isabella Skandorff Pedersen, Jakob Hjorth von Stemann, Jacob Morville Schrøder, Dan Ploug Christensen, Stine Falsig Pedersen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/88514809b5334da8bc2989f2186a830f
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