Decreased resting-state alpha-band activation and functional connectivity after sleep deprivation

Abstract Cognitive abilities are impaired by sleep deprivation and can be recovered when sufficient sleep is obtained. Changes in alpha-band oscillations are considered to be closely related to sleep deprivation. In this study, power spectrum, source localization and functional connectivity analyses...

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Autores principales:	Jintao Wu, Qianxiang Zhou, Jiaxuan Li, Yang Chen, Shuyu Shao, Yi Xiao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/88554f9d3be841a58f0fe7e2b8a76a0a
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spelling	oai:doaj.org-article:88554f9d3be841a58f0fe7e2b8a76a0a2021-12-02T15:22:56ZDecreased resting-state alpha-band activation and functional connectivity after sleep deprivation10.1038/s41598-020-79816-82045-2322https://doaj.org/article/88554f9d3be841a58f0fe7e2b8a76a0a2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79816-8https://doaj.org/toc/2045-2322Abstract Cognitive abilities are impaired by sleep deprivation and can be recovered when sufficient sleep is obtained. Changes in alpha-band oscillations are considered to be closely related to sleep deprivation. In this study, power spectrum, source localization and functional connectivity analyses were used to investigate the changes in resting-state alpha-band activity after normal sleep, sleep deprivation and recovery sleep. The results showed that the global alpha power spectrum decreased and source activation was notably reduced in the precuneus, posterior cingulate cortex, cingulate gyrus, and paracentral lobule after sleep deprivation. Functional connectivity analysis after sleep deprivation showed a weakened functional connectivity pattern in a widespread network with the precuneus and posterior cingulate cortex as the key nodes. Furthermore, the changes caused by sleep deprivation were reversed to a certain extent but not significantly after one night of sleep recovery, which may be due to inadequate time for recovery sleep. In conclusion, large-scale resting-state alpha-band activation and functional connectivity were weakened after sleep deprivation, and the inhibition of default mode network function with the precuneus and posterior cingulate cortex as the pivotal nodes may be an important cause of cognitive impairment. These findings provide new insight into the physiological response to sleep deprivation and determine how sleep deprivation disrupts brain alpha-band oscillations.Jintao WuQianxiang ZhouJiaxuan LiYang ChenShuyu ShaoYi XiaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jintao Wu Qianxiang Zhou Jiaxuan Li Yang Chen Shuyu Shao Yi Xiao Decreased resting-state alpha-band activation and functional connectivity after sleep deprivation
description	Abstract Cognitive abilities are impaired by sleep deprivation and can be recovered when sufficient sleep is obtained. Changes in alpha-band oscillations are considered to be closely related to sleep deprivation. In this study, power spectrum, source localization and functional connectivity analyses were used to investigate the changes in resting-state alpha-band activity after normal sleep, sleep deprivation and recovery sleep. The results showed that the global alpha power spectrum decreased and source activation was notably reduced in the precuneus, posterior cingulate cortex, cingulate gyrus, and paracentral lobule after sleep deprivation. Functional connectivity analysis after sleep deprivation showed a weakened functional connectivity pattern in a widespread network with the precuneus and posterior cingulate cortex as the key nodes. Furthermore, the changes caused by sleep deprivation were reversed to a certain extent but not significantly after one night of sleep recovery, which may be due to inadequate time for recovery sleep. In conclusion, large-scale resting-state alpha-band activation and functional connectivity were weakened after sleep deprivation, and the inhibition of default mode network function with the precuneus and posterior cingulate cortex as the pivotal nodes may be an important cause of cognitive impairment. These findings provide new insight into the physiological response to sleep deprivation and determine how sleep deprivation disrupts brain alpha-band oscillations.
format	article
author	Jintao Wu Qianxiang Zhou Jiaxuan Li Yang Chen Shuyu Shao Yi Xiao
author_facet	Jintao Wu Qianxiang Zhou Jiaxuan Li Yang Chen Shuyu Shao Yi Xiao
author_sort	Jintao Wu
title	Decreased resting-state alpha-band activation and functional connectivity after sleep deprivation
title_short	Decreased resting-state alpha-band activation and functional connectivity after sleep deprivation
title_full	Decreased resting-state alpha-band activation and functional connectivity after sleep deprivation
title_fullStr	Decreased resting-state alpha-band activation and functional connectivity after sleep deprivation
title_full_unstemmed	Decreased resting-state alpha-band activation and functional connectivity after sleep deprivation
title_sort	decreased resting-state alpha-band activation and functional connectivity after sleep deprivation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/88554f9d3be841a58f0fe7e2b8a76a0a
work_keys_str_mv	AT jintaowu decreasedrestingstatealphabandactivationandfunctionalconnectivityaftersleepdeprivation AT qianxiangzhou decreasedrestingstatealphabandactivationandfunctionalconnectivityaftersleepdeprivation AT jiaxuanli decreasedrestingstatealphabandactivationandfunctionalconnectivityaftersleepdeprivation AT yangchen decreasedrestingstatealphabandactivationandfunctionalconnectivityaftersleepdeprivation AT shuyushao decreasedrestingstatealphabandactivationandfunctionalconnectivityaftersleepdeprivation AT yixiao decreasedrestingstatealphabandactivationandfunctionalconnectivityaftersleepdeprivation
_version_	1718387390250221568

Decreased resting-state alpha-band activation and functional connectivity after sleep deprivation

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