Direct and Indirect endocrine-mediated suppression of human endometrial CD8+T cell cytotoxicity

Abstract Regulation of endometrial (EM) CD8+T cells is essential for successful reproduction and protection against pathogens. Suppression of CD8+T cells is necessary for a tolerogenic environment that promotes implantation and pregnancy. However, the mechanisms regulating this process remain unclea...

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Autores principales:	Z. Shen, M. Rodriguez-Garcia, M. V. Patel, C. R. Wira
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/88556209672945608b2161cd22dd61df
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spelling	oai:doaj.org-article:88556209672945608b2161cd22dd61df2021-12-02T13:48:41ZDirect and Indirect endocrine-mediated suppression of human endometrial CD8+T cell cytotoxicity10.1038/s41598-021-81380-82045-2322https://doaj.org/article/88556209672945608b2161cd22dd61df2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81380-8https://doaj.org/toc/2045-2322Abstract Regulation of endometrial (EM) CD8+T cells is essential for successful reproduction and protection against pathogens. Suppression of CD8+T cells is necessary for a tolerogenic environment that promotes implantation and pregnancy. However, the mechanisms regulating this process remain unclear. Sex hormones are known to control immune responses directly on immune cells and indirectly through the tissue environment. When the actions of estradiol (E2), progesterone (P) and TGFβ on EM CD8+T cells were evaluated, cytotoxic activity, perforin and granzymes were directly suppressed by E2 and TGFβ but not P. Moreover, incubation of polarized EM epithelial cells with P, but not E2, increased TGFβ secretion. These findings suggest that E2 acts directly on CD8+T cell to suppress cytotoxic activity while P acts indirectly through induction of TGFβ production. Understanding the mechanisms involved in regulating endometrial CD8+T cells is essential for optimizing reproductive success and developing protective strategies against genital infections and gynecological cancers.Z. ShenM. Rodriguez-GarciaM. V. PatelC. R. WiraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Z. Shen M. Rodriguez-Garcia M. V. Patel C. R. Wira Direct and Indirect endocrine-mediated suppression of human endometrial CD8+T cell cytotoxicity
description	Abstract Regulation of endometrial (EM) CD8+T cells is essential for successful reproduction and protection against pathogens. Suppression of CD8+T cells is necessary for a tolerogenic environment that promotes implantation and pregnancy. However, the mechanisms regulating this process remain unclear. Sex hormones are known to control immune responses directly on immune cells and indirectly through the tissue environment. When the actions of estradiol (E2), progesterone (P) and TGFβ on EM CD8+T cells were evaluated, cytotoxic activity, perforin and granzymes were directly suppressed by E2 and TGFβ but not P. Moreover, incubation of polarized EM epithelial cells with P, but not E2, increased TGFβ secretion. These findings suggest that E2 acts directly on CD8+T cell to suppress cytotoxic activity while P acts indirectly through induction of TGFβ production. Understanding the mechanisms involved in regulating endometrial CD8+T cells is essential for optimizing reproductive success and developing protective strategies against genital infections and gynecological cancers.
format	article
author	Z. Shen M. Rodriguez-Garcia M. V. Patel C. R. Wira
author_facet	Z. Shen M. Rodriguez-Garcia M. V. Patel C. R. Wira
author_sort	Z. Shen
title	Direct and Indirect endocrine-mediated suppression of human endometrial CD8+T cell cytotoxicity
title_short	Direct and Indirect endocrine-mediated suppression of human endometrial CD8+T cell cytotoxicity
title_full	Direct and Indirect endocrine-mediated suppression of human endometrial CD8+T cell cytotoxicity
title_fullStr	Direct and Indirect endocrine-mediated suppression of human endometrial CD8+T cell cytotoxicity
title_full_unstemmed	Direct and Indirect endocrine-mediated suppression of human endometrial CD8+T cell cytotoxicity
title_sort	direct and indirect endocrine-mediated suppression of human endometrial cd8+t cell cytotoxicity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/88556209672945608b2161cd22dd61df
work_keys_str_mv	AT zshen directandindirectendocrinemediatedsuppressionofhumanendometrialcd8tcellcytotoxicity AT mrodriguezgarcia directandindirectendocrinemediatedsuppressionofhumanendometrialcd8tcellcytotoxicity AT mvpatel directandindirectendocrinemediatedsuppressionofhumanendometrialcd8tcellcytotoxicity AT crwira directandindirectendocrinemediatedsuppressionofhumanendometrialcd8tcellcytotoxicity
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Direct and Indirect endocrine-mediated suppression of human endometrial CD8+T cell cytotoxicity

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